APOL3 and HAS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOL3	HAS3
Description		apolipoprotein L3	hyaluronan synthase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Golgi Membrane Nucleus Cytoplasm Endosome Early Endosome Golgi Apparatus Plasma Membrane Membrane Hyaluranon Cable
	Molecular Function	Lipid Transporter Activity Protein Binding Lipid Binding	Protein Binding Transferase Activity Glycosyltransferase Activity Identical Protein Binding Hyaluronan Synthase Activity
	Biological Process	Lipid Transport Inflammatory Response Lipoprotein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction	Polysaccharide Biosynthetic Process Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Hyaluronan Biosynthetic Process Positive Regulation Of DNA-templated Transcription Extracellular Matrix Assembly Positive Regulation Of Hyaluranon Cable Assembly
Pathways			Hyaluronan metabolism
Drugs
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Total intracranial volume ( 31530798)	Attention deficit hyperactivity disorder ( 18821565) Body mass index ( 26426971) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653)
Interacting Genes		33 interacting genes: AQP6 CYB5R3 ELOVL4 FAM209A FATE1 FXYD6-FXYD2 GJA8 GJB1 GJB5 GJC1 GPR152 GPRC5D HAS3 IL7R LHFPL5 LINC00839 LRRC25 MFSD6 NCALD PMP22 RNF19B SGCB SLC10A1 SLC16A2 SLC1A5 SLC35H1 SLC7A14 STX1A TIMMDC1 TMEM167B TMEM237 TMEM52B TNFRSF10D	6 interacting genes: APOL3 C14orf180 CMTM7 LHFPL5 PLP1 SYNGR1
Entrez ID		80833	3038
HPRD ID		06264	03889
Ensembl ID		ENSG00000128284	ENSG00000103044
Uniprot IDs		O95236	O00219 Q96RV2
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Transmembrane Transport Amino Acid Transmembrane Transporter Activity Gap Junction Assembly Plasma Membrane Organic Anion Transport Amino Acid Transmembrane Transport
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