APOL3 and SLC1A5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		APOL3	SLC1A5
Description		apolipoprotein L3	solute carrier family 1 member 5
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Cytoplasm Membrane	Plasma Membrane Basal Plasma Membrane Membrane Centriolar Satellite Ciliary Basal Body Melanosome Extracellular Exosome
	Molecular Function	Lipid Transporter Activity Protein Binding Lipid Binding	Virus Receptor Activity Protein Binding Amino Acid Transmembrane Transporter Activity Neutral L-amino Acid Transmembrane Transporter Activity L-aspartate Transmembrane Transporter Activity L-glutamine Transmembrane Transporter Activity L-serine Transmembrane Transporter Activity Symporter Activity Antiporter Activity Ligand-gated Channel Activity Signaling Receptor Activity Metal Ion Binding
	Biological Process	Lipid Transport Inflammatory Response Lipoprotein Metabolic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction	Amino Acid Transport Glutamine Transport Glutamine Secretion Neutral Amino Acid Transport L-serine Transport Erythrocyte Differentiation Symbiont Entry Into Host Cell Protein Homotrimerization L-aspartate Import Across Plasma Membrane Transport Across Blood-brain Barrier L-glutamine Import Across Plasma Membrane
Pathways			Amino acid transport across the plasma membrane RAC1 GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOJ GTPase cycle RAC3 GTPase cycle
Drugs			Asparagine Fluciclovine (18F)
Diseases
GWAS		Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel + carboplatin) ( 23648065) Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (alkaline phosphatase) ( 33972514) Serum alkaline phosphatase levels ( 33547301) Total intracranial volume ( 31530798)	Appendicular lean mass ( 33097823) Conjunctival UV autofluorescence (CUVAF) ( 25590795) Metabolite levels ( 23823483)
Interacting Genes		33 interacting genes: AQP6 CYB5R3 ELOVL4 FAM209A FATE1 FXYD6-FXYD2 GJA8 GJB1 GJB5 GJC1 GPR152 GPRC5D HAS3 IL7R LHFPL5 LINC00839 LRRC25 MFSD6 NCALD PMP22 RNF19B SGCB SLC10A1 SLC16A2 SLC1A5 SLC35H1 SLC7A14 STX1A TIMMDC1 TMEM167B TMEM237 TMEM52B TNFRSF10D	6 interacting genes: APOL3 ERVW-1 PLP1 SLC25A21-AS1 TBC1D17 TRARG1
Entrez ID		80833	6510
HPRD ID		06264	00173
Ensembl ID		ENSG00000128284	ENSG00000105281
Uniprot IDs		O95236	Q15758 Q59ES3
PDB IDs			5LLM 5LLU 5LM4 5MJU 6GCT 6MP6 6MPB 6RVX 6RVY 7BCQ 7BCS 7BCT 8OUD 8OUH 8OUJ 8QRO 8QRP 8QRQ 8QRR 8QRS 8QRU 8QRV 8QRW
Enriched GO Terms of Interacting Partners?		Membrane Connexin Complex Gap Junction Channel Activity Gap Junction Transmembrane Transport Amino Acid Transmembrane Transporter Activity Gap Junction Assembly Plasma Membrane Organic Anion Transport Amino Acid Transmembrane Transport
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