SGCB and CMTM5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGCB	CMTM5
Description		sarcoglycan beta	CKLF like MARVEL transmembrane domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma	Extracellular Space Membrane
	Molecular Function	Protein Binding	Cytokine Activity Protein Binding
	Biological Process	Muscle Organ Development Response To Glucose Gene Expression Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Muscle Cell Development Cardiac Muscle Cell Development Vascular Associated Smooth Muscle Cell Development	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS
Interacting Genes		22 interacting genes: ADAM33 ADRA1A APOL3 ATP1B4 CLEC7A CMTM5 EHHADH HTR2C LTB4R2 MAL MGST2 NINJ1 PTTG1IP SGCA SGCD SGCG SGCZ SLC52A1 SMIM3 TMEM11 TNF TRIM63	133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599
Entrez ID		6443	116173
HPRD ID		02942	06986
Ensembl ID		ENSG00000163069	ENSG00000166091
Uniprot IDs		Q16585 Q5U0N0	Q96DZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Sarcoglycan Complex Dystroglycan Complex Membrane Heart Contraction Muscle Contraction Heart Process Sarcolemma Muscle System Process Circulatory System Process Plasma Membrane Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Action Potential Cardiac Muscle Tissue Development Negative Regulation Of Heart Rate Dystrophin-associated Glycoprotein Complex Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Muscle Organ Development Negative Regulation Of Myoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Ferroptosis Muscle Structure Development Muscle Tissue Development Negative Regulation Of Bile Acid Secretion Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Metabolic Process Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Inflammatory Response Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure System Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity	Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity
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