SGCB and NINJ1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SGCB	NINJ1
Description		sarcoglycan beta	ninjurin 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Cytoplasm Endoplasmic Reticulum Membrane Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Dystroglycan Complex Sarcoglycan Complex Membrane Sarcolemma	Extracellular Region Plasma Membrane Membrane Synapse Synaptic Membrane
	Molecular Function	Protein Binding	Lipopolysaccharide Binding Protein Binding Cell Adhesion Mediator Activity Membrane Destabilizing Activity
	Biological Process	Muscle Organ Development Response To Glucose Gene Expression Glucose Homeostasis Glucose Import In Response To Insulin Stimulus Muscle Cell Development Cardiac Muscle Cell Development Vascular Associated Smooth Muscle Cell Development	Angiogenesis Leukocyte Chemotaxis Involved In Inflammatory Response Inflammatory Response Cell Adhesion Nervous System Development Cytolysis Killing Of Cells Of Another Organism Heterotypic Cell-cell Adhesion Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Tissue Regeneration Muscle Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Inflammatory Response Protein Homooligomerization Cellular Hyperosmotic Response Regulation Of Monocyte Chemotaxis Programmed Necrotic Cell Death Ferroptosis Pyroptotic Cell Death
Pathways		Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Limb-girdle muscular dystrophy (LGMD) Sarcoglycanopathies, including: Limb-girdle muscular dystrophy (LGMD) 2C; Limb-girdle muscular dystrophy (LGMD) 2D; Limb-girdle muscular dystrophy (LGMD) 2E; Limb-girdle muscular dystrophy (LGMD) 2F
GWAS			Alanine aminotransferase levels ( 33547301 34315874) Aspartate aminotransferase levels ( 33547301 34315874) Lactate dehydrogenase levels ( 29403010) Liver enzyme levels (alanine transaminase) ( 33972514) Obesity (early onset extreme) ( 23563609)
Interacting Genes		22 interacting genes: ADAM33 ADRA1A APOL3 ATP1B4 CLEC7A CMTM5 EHHADH HTR2C LTB4R2 MAL MGST2 NINJ1 PTTG1IP SGCA SGCD SGCG SGCZ SLC52A1 SMIM3 TMEM11 TNF TRIM63	21 interacting genes: AQP6 ATP6AP2 CD200R1 CEACAM3 CREB3L1 CYB5R3 EBP FCGR1A FNDC9 GOLM1 GPX8 HIVEP1 KRT40 LIME1 MUC1 PVR SGCB TIMMDC1 TLCD4 TMEM14B TMEM31
Entrez ID		6443	4814
HPRD ID		02942	03639
Ensembl ID		ENSG00000163069	ENSG00000131669
Uniprot IDs		Q16585 Q5U0N0	Q92982
PDB IDs			8CQR 8SZA 8UIP
Enriched GO Terms of Interacting Partners?		Sarcoglycan Complex Dystroglycan Complex Membrane Heart Contraction Muscle Contraction Heart Process Sarcolemma Muscle System Process Circulatory System Process Plasma Membrane Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Action Potential Cardiac Muscle Tissue Development Negative Regulation Of Heart Rate Dystrophin-associated Glycoprotein Complex Regulation Of Calcium-mediated Signaling Positive Regulation Of Calcineurin-NFAT Signaling Cascade Negative Regulation Of Heart Contraction Negative Regulation Of Blood Circulation Muscle Organ Development Negative Regulation Of Myoblast Differentiation Striated Muscle Tissue Development Negative Regulation Of Heart Rate Involved In Baroreceptor Response To Increased Systemic Arterial Blood Pressure Protein Insertion Into Plasma Membrane Hinge Region Between Urothelial Plaques Of Apical Plasma Membrane Ferroptosis Muscle Structure Development Muscle Tissue Development Negative Regulation Of Bile Acid Secretion Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Translational Initiation By Iron Positive Regulation Of Interleukin-33 Production Regulation Of Calcineurin-mediated Signaling Regulation Of Calcineurin-NFAT Signaling Cascade Response To Gram-negative Bacterium Negative Regulation Of Branching Involved In Lung Morphogenesis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Nitric Oxide Metabolic Process Detection Of Yeast Detection Of Molecule Of Fungal Origin Positive Regulation Of Inflammatory Response Positive Regulation Of The Force Of Heart Contraction By Epinephrine-norepinephrine Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Positive Regulation Of MAPK Cascade Positive Regulation Of ERK1 And ERK2 Cascade Phospholipase C-activating Adrenergic Receptor Signaling Pathway Regulation Of Action Potential Norepinephrine-epinephrine Vasoconstriction Involved In Regulation Of Systemic Arterial Blood Pressure System Process Long-chain (3S)-3-hydroxyacyl-CoA Dehydrogenase (NAD+) Activity	Membrane
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