KCNIP4 and ASPH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNIP4	ASPH
Description		potassium voltage-gated channel interacting protein 4	aspartate beta-hydroxylase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Peroxisome Endoplasmic Reticulum Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex	Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Membrane Sarcoplasmic Reticulum Lumen Calcium Channel Complex
	Molecular Function	Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Metal Ion Binding	Structural Molecule Activity Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Electron Transfer Activity Oxidoreductase Activity Transmembrane Transporter Binding Metal Ion Binding Dioxygenase Activity Peptidyl-aspartic Acid 3-dioxygenase Activity
	Biological Process	Monoatomic Ion Transport Potassium Ion Transport Regulation Of Signal Transduction Monoatomic Ion Transmembrane Transport Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Detection Of Calcium Ion Muscle Contraction Pattern Specification Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Regulation Of Protein Stability Activation Of Store-operated Calcium Channel Activity Response To ATP Limb Morphogenesis Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Homeostasis Roof Of Mouth Development Face Morphogenesis Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Positive Regulation Of Intracellular Protein Transport Regulation Of Protein Depolymerization
Pathways		Phase 1 - inactivation of fast Na+ channels	Stimuli-sensing channels Ion homeostasis Protein hydroxylation
Drugs			Aspartic acid
Diseases
GWAS		Appendicular lean mass ( 33097823) Cadmium levels ( 26025379) Colorectal cancer ( 29228715) Cough in response to angiotensin-converting enzyme inhibitor drugs ( 26169577) Diverticular disease ( 30177863) Lingual gyrus volume ( 31530798) Obesity-related traits ( 23251661) Parkinson disease and lewy body pathology ( 25663231) Post bronchodilator FEV1/FVC ratio ( 26634245) Postburn scar height ( 30595539) Rheumatoid arthritis ( 21156761) Suicidal ideation ( 20877300)	Blood protein levels ( 30072576) BRCA1/2-negative high-risk breast cancer ( 30323354) Resting heart rate ( 28270201) Serum omega-6 to omega-3 polyunsaturated fatty acid ratio in metabolic syndrome ( 31991592) Urate levels in overweight individuals ( 25811787)
Interacting Genes		11 interacting genes: APP ASPH COL1A2 GOLGA7 IL17A KCND2 LITAF MEOX2 PSEN1 PSEN2 TRH	73 interacting genes: - AGR2 APP BGLAP CDSN CHRM5 CST1 CTSA CXorf66 DCD DEFB1 DHRSX ENPP6 FBXO7 FDCSP FGFBP1 FKBP7 GAL GAST GET3 GOLM1 GPR119 GPX7 GPX8 GSC2 GUCA2A IL21 INSL5 KCNIP1 KCNIP3 KCNIP4 LCN2 LINC00632 LRPAP1 LTA NUCB2 OCIAD1 OGT PCSK4 PDGFA PDGFRL PLAAT2 PLEKHF2 PRAP1 PRB1 PRB2 PRB4 PRH1 PTH PTN RCN1 RELL2 RNASEH1 SCGB1C2 SDC2 SF3A2 SGTB SHISAL1 SLC51B SMIM11 SMIM19 SOD3 SPINK1 TMEM167B TMX2 TNFRSF10B TRDN TUFM TXNDC15 UGT2B11 WFDC12 WFDC5 ZG16
Entrez ID		80333	444
HPRD ID		12184	08996
Ensembl ID		ENSG00000185774	ENSG00000198363
Uniprot IDs		A8K4N3 Q3YAB7 Q6PIL6	B4DQ07 B7ZM96 G3XAN5 Q12797
PDB IDs			5APA 5JQY 5JTC 5JZ6 5JZ8 5JZA 5JZU 6Q9F 6Q9I 6QA5 6RK9 6YYU 6YYV 6YYW 6YYX 6YYY 6Z6Q 6Z6R 7BMI 7BMJ 7E6J 7YB8 7YB9 7YBA 7YBB 7YBC 8RE5 8RE6 8RE7 8RE8 8RE9
Enriched GO Terms of Interacting Partners?		Notch Signaling Pathway Positive Regulation Of Amyloid Fibril Formation Growth Factor Receptor Binding Astrocyte Activation Involved In Immune Response Aspartic Endopeptidase Activity, Intramembrane Cleaving Synaptic Membrane Gamma-secretase Complex Positive Regulation Of Protein Transport Notch Receptor Processing Amyloid-beta Formation Neuron Projection Maintenance Skin Morphogenesis Positive Regulation Of Establishment Of Protein Localization Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Protein Trimerization Amyloid Precursor Protein Catabolic Process Regulation Of Amyloid Fibril Formation Astrocyte Activation Regulation Of Calcium Ion Transmembrane Transport Inorganic Ion Homeostasis Positive Regulation Of Glycolytic Process Membrane Protein Ectodomain Proteolysis Amyloid-beta Metabolic Process Positive Regulation Of Amino Acid Transport Amyloid Precursor Protein Metabolic Process Regulation Of Protein Transport Positive Regulation Of Protein Localization Regulation Of Tumor Necrosis Factor Production Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Positive Regulation Of Proteolysis Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Protein Localization Early Endosome Membrane Positive Regulation Of ATP Metabolic Process Locomotory Behavior Positive Regulation Of DNA-templated Transcription Membrane Protein Proteolysis Dendritic Shaft Calcium Ion Homeostasis Neuron Projection Organization Regulation Of Biological Quality Regulation Of Calcium Ion Transport Positive Regulation Of RNA Metabolic Process Cell-cell Signaling Protein Complex Oligomerization Regulation Of Blood Circulation Cellular Response To Amyloid-beta Signaling	Extracellular Region Golgi Lumen Extracellular Space Endoplasmic Reticulum Lumen Hormone Activity Defense Response To Bacterium Response To Bacterium Endoplasmic Reticulum Antibacterial Humoral Response Defense Response To Gram-positive Bacterium Regulation Of Metal Ion Transport Peptidase Inhibitor Activity Regulation Of Monoatomic Cation Transmembrane Transport Regulation Of Potassium Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport
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