CHD9 and PPARA

Number of citations of the paper that reports this interaction (PMID 16554032)
9

Data Source:
HPRD (in vitro, in vivo)

		CHD9	PPARA
Gene Name		chromodomain helicase DNA binding protein 9	peroxisome proliferator-activated receptor alpha
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Plasma Membrane	Nucleus Nucleoplasm
	Molecular Function	DNA Binding Helicase Activity Protein Binding ATP Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Negative Regulation Of Transcription RNA Polymerase II Repressing Transcription Factor Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Steroid Hormone Receptor Activity Ligand-activated Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Activity Protein Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Protein Complex Binding Sequence-specific DNA Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Chromatin Modification Cellular Lipid Metabolic Process Small Molecule Metabolic Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Lipid Metabolic Process Fatty Acid Metabolic Process Heart Development Circadian Rhythm Epidermis Development Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Receptor Biosynthetic Process Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Fatty Acid Transport Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Cellular Lipid Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Fatty Acid Oxidation Enamel Mineralization Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Cellular Ketone Metabolic Process By Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Lipid Transport By Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Neuron Death Negative Regulation Of Transcription Regulatory Region DNA Binding
Pathways		PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Activation of gene expression by SREBF (SREBP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters	PPARA activates gene expression Organelle biogenesis and maintenance Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Nuclear Receptor transcription pathway REV-ERBA represses gene expression RORA activates circadian gene expression Mitochondrial biogenesis Regulation of cholesterol biosynthesis by SREBP (SREBF) Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation YAP1- and WWTR1 (TAZ)-stimulated gene expression Activation of gene expression by SREBF (SREBP) Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) Transcriptional activation of mitochondrial biogenesis BMAL1:CLOCK,NPAS2 activates circadian gene expression Orphan transporters
Drugs			Clofibrate Fenofibrate Gemfibrozil Bezafibrate Deoxy-Bigchap 2-METHYL-2-(4-{[({4-METHYL-2-[4-(TRIFLUOROMETHYL)PHENYL]-1,3-THIAZOL-5-YL}CARBONYL)AMINO]METHYL}PHENOXY)PROPANOIC ACID 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid ALEGLITAZAR
Diseases
GWAS
Protein-Protein Interactions		5 interactors: ESR1 NR1I3 NR3C1 PPARA RXRA	44 interactors: AIP AKAP13 CDK3 CEP350 CHD9 DAP3 DUT EP300 FABP1 FOXA3 GADD45A GADD45B GADD45G HELZ2 HSP90AA1 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H3 NRBF2 NRIP1 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SIRT1 SRC STAC3 SUMO1 TNP1 UBE2I
Entrez ID		80205	5465
HPRD ID		08570	01369
Ensembl ID		ENSG00000177200	ENSG00000186951
Uniprot IDs		Q3L8U1 Q461N2	F1D8S4 Q07869
PDB IDs			1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR
Enriched GO Terms of Interacting Partners?		Steroid Hormone Mediated Signaling Pathway Hormone-mediated Signaling Pathway Transcription Initiation From RNA Polymerase II Promoter Cellular Response To Steroid Hormone Stimulus Intracellular Receptor Signaling Pathway DNA-templated Transcription, Initiation Cellular Response To Organic Cyclic Compound Cellular Response To Lipid Response To Steroid Hormone Cellular Response To Hormone Stimulus Response To Lipid Transcription From RNA Polymerase II Promoter Response To Organic Cyclic Compound Response To Hormone Positive Regulation Of Transcription From RNA Polymerase II Promoter Intracellular Steroid Hormone Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Regulation Of Branching Involved In Prostate Gland Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Cellular Response To Organic Substance Transcription, DNA-templated RNA Biosynthetic Process Steroid Metabolic Process Response To Organic Substance Organ Morphogenesis Positive Regulation Of Cellular Metabolic Process Epithelium Development Regulation Of Gluconeogenesis Lipid Metabolic Process Negative Regulation Of Gene Expression RNA Metabolic Process Mammary Gland Duct Morphogenesis Positive Regulation Of Metabolic Process Gene Expression Regulation Of Morphogenesis Of A Branching Structure Prostate Gland Development Cellular Macromolecule Biosynthetic Process Gland Development Macromolecule Biosynthetic Process Maternal Process Involved In Female Pregnancy Mammary Gland Morphogenesis Tissue Development Mammary Gland Epithelium Development Regulation Of Glucose Metabolic Process Tissue Morphogenesis Regulation Of Transcription, DNA-templated Regulation Of Glycolytic By Positive Regulation Of Transcription From RNA Polymerase II Promoter	Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Metabolic Process Intracellular Receptor Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Transcription, DNA-templated Regulation Of Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Gene Expression Regulation Of RNA Metabolic Process Intracellular Steroid Hormone Receptor Signaling Pathway Transcription, DNA-templated Gene Expression Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Response To Hormone DNA-templated Transcription, Initiation Organelle Organization Regulation Of Gene Expression Cellular Response To Organic Substance Chromatin Organization Transcription Initiation From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Cellular Metabolic Process Chromatin Modification Negative Regulation Of Transcription, DNA-templated Macromolecule Biosynthetic Process Regulation Of Signal Transduction Negative Regulation Of Nucleic Acid-templated Transcription Response To Organic Substance Peptidyl-amino Acid Modification Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Biosynthetic Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Transcription From RNA Polymerase II Promoter Cellular Response To Hormone Stimulus Regulation Of Signaling Signal Transduction Response To Steroid Hormone Negative Regulation Of Gene Expression Positive Regulation Of Cellular Protein Metabolic Process Cellular Response To Stimulus Cell Communication Nucleobase-containing Compound Metabolic Process
Tagcloud ?			abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
Tagcloud (Difference) ?			abca1 alfalfa aragonesa breed concentrate contrary dams finishing grazed grazing indoors lambs lengths lpl lt pparg rasa scarb1 sf slaughtering srebp1 subcutaneous supplemented thoracis tocopherol tocopheryl ve10d ve20d ve30d
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