CHD9

Description		chromodomain helicase DNA binding protein 9
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding DNA Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Chromatin Organization
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Regulation of lipid metabolism by PPARalpha Cytoprotection by HMOX1 Heme signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Body mass index ( 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Mean platelet volume ( 32888494) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 27863252 32888494) Morning person ( 30696823) Neutrophil count ( 32888494) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Platelet count ( 32888494) Response to fenofibrate (triglyceride levels) ( 27002377)
Interacting Genes		7 interacting genes: APP ESR1 NR1I3 NR3C1 PPARA RXRA TIAM1
Entrez ID		80205
HPRD ID		08570
Ensembl ID		ENSG00000177200
Uniprot IDs		H3BTW3 Q3L8U1
PDB IDs
Enriched GO Terms of Interacting Partners?		Nuclear Receptor Activity Regulation Of MiRNA Transcription Steroid Hormone Receptor Signaling Pathway Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Regulation Of MiRNA Metabolic Process Nuclear Receptor-mediated Signaling Pathway Nuclear Steroid Receptor Activity Negative Regulation Of MiRNA Transcription Intracellular Signal Transduction Hormone-mediated Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Sequence-specific DNA Binding Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Lipid Binding Estrogen Response Element Binding Positive Regulation Of RNA Metabolic Process Peroxisome Proliferator Activated Receptor Signaling Pathway RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process Sequence-specific Double-stranded DNA Binding TBP-class Protein Binding Regulation Of Transcription By RNA Polymerase II Steroid Binding Signal Transduction Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Lipoprotein Metabolic Process Reproductive Behavior Regulation Of Response To Nutrient Levels Positive Regulation Of Biosynthetic Process Positive Regulation Of ATP Metabolic Process Negative Regulation Of Metabolic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Nitric Oxide Metabolic Process Transcription Coregulator Binding
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