TMEM134 and SLC22A2

Number of citations of the paper that reports this interaction (PubMedID 31318583)
0

Data Source:
BioGRID (protein complementation assay)

		TMEM134	SLC22A2
Description		transmembrane protein 134	solute carrier family 22 member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Basal Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Extracellular Exosome Presynapse
	Molecular Function	Protein Binding	Amine Transmembrane Transporter Activity Acetylcholine Transmembrane Transporter Activity Neurotransmitter Transmembrane Transporter Activity Monoamine Transmembrane Transporter Activity Organic Anion Transmembrane Transporter Activity Organic Cation Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity L-amino Acid Transmembrane Transporter Activity Pyrimidine Nucleoside Transmembrane Transporter Activity Choline Transmembrane Transporter Activity Thiamine Transmembrane Transporter Activity Putrescine Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity Spermidine Transmembrane Transporter Activity Quaternary Ammonium Group Transmembrane Transporter Activity Toxin Transmembrane Transporter Activity Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity L-arginine Transmembrane Transporter Activity
	Biological Process		Monoatomic Ion Transport Monoatomic Cation Transport Neurotransmitter Transport Serotonin Transport Body Fluid Secretion Organic Cation Transport Quaternary Ammonium Group Transport Prostaglandin Transport Amine Transport Putrescine Transport Spermidine Transport Acetylcholine Transport Choline Transport Dopamine Transport Norepinephrine Transport Xenobiotic Transport Epinephrine Transport Histamine Transport Serotonin Uptake Histamine Uptake Norepinephrine Uptake Transmembrane Transport Thiamine Transmembrane Transport Purine-containing Compound Transmembrane Transport Amino Acid Import Across Plasma Membrane Dopamine Uptake L-arginine Import Across Plasma Membrane Export Across Plasma Membrane Transport Across Blood-brain Barrier L-alpha-amino Acid Transmembrane Transport Spermidine Transmembrane Transport L-arginine Transmembrane Transport Cellular Detoxification Xenobiotic Transport Across Blood-brain Barrier
Pathways			Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport SLC-mediated transport of neurotransmitters SLC-mediated transport of organic cations
Drugs
Diseases
GWAS		Refractive error ( 32231278)	A body shape index ( 34021172) Body mass index ( 25673413 26426971) Body mass index (age>50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Chronic kidney disease ( 20383146 31152163) Creatinine levels ( 31015462 29403010 20383145) Estimated glomerular filtration rate ( 31451708 31152163 31015462 30604766) Estimated glomerular filtration rate in diabetes ( 31451708) Estimated glomerular filtration rate in non-diabetics ( 31451708) Familial squamous cell lung carcinoma ( 29924316) Glomerular filtration rate ( 29403010 27588450) Glomerular filtration rate (creatinine) ( 28452372 26831199) Glomerular filtration rate in non diabetics (creatinine) ( 26831199) Hip circumference adjusted for BMI ( 34021172) Kidney stones ( 31729369) Lipoprotein (a) levels ( 26377243) Lipoprotein (a) levels in coronary artery disease (percutaneous coronary intervention) ( 31186284) Prostate cancer ( 26034056) Serum metabolite levels ( 23093944) Type 2 diabetes or prostate cancer (pleiotropy) ( 33290408) Waist circumference ( 26785701) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		6 interacting genes: CLN8 ERBB2 ERBB3 ERBB4 SLC22A2 VKORC1	45 interacting genes: AGO3 CCL2 CD63 CD9 CLPTM1 CST9L CYB5R3 DPM2 EEF1G ETV5 FAIM2 FIS1 FXYD2 FZD5 GTF2B HNRNPH3 HRCT1 HYAL3 ITM2C KRTCAP2 LAPTM4A LAPTM4B LAPTM5 LSM4 NCOA3 PDIA6 PDZK1IP1 POU2AF1 PRPF8 RPN2 SERP1 SLC40A1 SLC47A2 SNCA SPCS1 STX8 SUMO2 TMEM134 TMEM147 TMEM161A TMEM176B TMEM41B TMX2 TREX1 VKORC1
Entrez ID		80194	6582
HPRD ID		08642	04008
Ensembl ID		ENSG00000172663	ENSG00000112499
Uniprot IDs		Q9H6X4	O15244
PDB IDs			8ET9
Enriched GO Terms of Interacting Partners?		Basal Plasma Membrane ERBB2 Signaling Pathway ERBB3:ERBB2 Complex Neuregulin Receptor Activity Basolateral Plasma Membrane ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Neurotransmitter Reuptake Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Peripheral Nervous System Development Neurotransmitter Uptake Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Amino Acid Import Across Plasma Membrane Heart Development Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Receptor Localization To Synapse Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor L-alpha-amino Acid Transmembrane Transport System Development Protein Localization To Synapse Apical Plasma Membrane Regulation Of Epithelial Cell Proliferation Glial Cell Development Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels L-amino Acid Transport Wound Healing Body Fluid Secretion Neuromuscular Junction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis	Membrane Endoplasmic Reticulum Oligosaccharyltransferase Complex Regulation Of Lysosomal Membrane Permeability Endoplasmic Reticulum Membrane Multivesicular Body, Internal Vesicle Response To Peptide
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