TMEM134 and CLN8

Number of citations of the paper that reports this interaction (PubMedID 23142642)
0

Data Source:
BioGRID (two hybrid)

		TMEM134	CLN8
Description		transmembrane protein 134	CLN8 transmembrane ER and ERGIC protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Perinuclear Region Of Cytoplasm	Mitochondrion Endoplasmic Reticulum Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Presynapse
	Molecular Function	Protein Binding	Protein Binding Ceramide Binding
	Biological Process		Phospholipid Metabolic Process Ceramide Metabolic Process Lipid Transport Apoptotic Process Mitochondrial Membrane Organization Lysosome Organization Nervous System Development Visual Perception Adult Walking Behavior Cholesterol Metabolic Process Associative Learning Adult Locomotory Behavior Regulation Of Cell Size Lipid Biosynthetic Process Macromolecule Catabolic Process Spinal Cord Motor Neuron Differentiation Somatic Motor Neuron Differentiation Protein Catabolic Process Social Behavior Negative Regulation Of Neuron Apoptotic Process Photoreceptor Cell Maintenance Negative Regulation Of Proteolysis Ceramide Biosynthetic Process Musculoskeletal Movement Neuromuscular Process Controlling Posture Neuromuscular Process Controlling Balance Neuron Apoptotic Process Glutamate Reuptake Lipid Homeostasis Retina Development In Camera-type Eye Neurofilament Cytoskeleton Organization Retinal Rod Cell Apoptotic Process
Pathways
Drugs
Diseases			Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD) Neuronal ceroid lipofuscinosis, including: Infantile Neuronal Ceroid Lipofuscinosis (INCL)/ Santavuori-Haltia Disease (CLN1); Late-Infantile Neuronal Ceroid Lipofuscinosis (LINCL)/ Jansky-Bielschowsky Disease (CLN2); Juvenile Neuronal Ceroid Lipofuscinosis (JNCL)/Batten Disease/ Spielmeyer-Vogt Disease (CLN3); Adult Neuronal Ceroid Lipofuscinosis (ANCL)/ Kufs Disease (CLN4); LINCL variant (CLN5, CLN6, CLN7, CLN8); Batten Disease variant (CLN9); Congenital NCL (CLN10)
GWAS		Refractive error ( 32231278)	Eye morphology ( 29921221) Gaucher disease severity ( 22388998) Systolic blood pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931)
Interacting Genes		6 interacting genes: CLN8 ERBB2 ERBB3 ERBB4 SLC22A2 VKORC1	31 interacting genes: ARL6IP5 BNIP3 BNIP3L CD9 CYB5B ERG28 FZD7 GABARAPL2 GPM6B MTX1 NDRG2 PDIA6 PLP1 PLP2 PTPRN RRP15 RTN4 SELENOK SPCS2 STX8 TMEM107 TMEM11 TMEM128 TMEM134 TMEM147 TMEM14A TUBB4A UBC USP40 YIPF6 ZUP1
Entrez ID		80194	2055
HPRD ID		08642	06383
Ensembl ID		ENSG00000172663	ENSG00000182372
Uniprot IDs		Q9H6X4	Q9UBY8
PDB IDs
Enriched GO Terms of Interacting Partners?		Basal Plasma Membrane ERBB2 Signaling Pathway ERBB3:ERBB2 Complex Neuregulin Receptor Activity Basolateral Plasma Membrane ErbB-3 Class Receptor Binding ERBB2-ERBB4 Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Neuron Differentiation ERBB2-ERBB3 Signaling Pathway ERBB3 Signaling Pathway ERBB4 Signaling Pathway Protein Tyrosine Kinase Activity Schwann Cell Development Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Neurotransmitter Reuptake Receptor Complex Positive Regulation Of Epithelial Cell Proliferation Peripheral Nervous System Development Neurotransmitter Uptake Protein Localization To Postsynaptic Membrane Protein Localization To Postsynapse Amino Acid Import Across Plasma Membrane Heart Development Negative Regulation Of Apoptotic Process Regulation Of Body Fluid Levels Negative Regulation Of Programmed Cell Death Growth Factor Binding Cellular Response To Epidermal Growth Factor Stimulus Receptor Localization To Synapse Transmembrane Receptor Protein Tyrosine Kinase Activity Peptidyl-tyrosine Phosphorylation Response To Epidermal Growth Factor L-alpha-amino Acid Transmembrane Transport System Development Protein Localization To Synapse Apical Plasma Membrane Regulation Of Epithelial Cell Proliferation Glial Cell Development Protein-containing Complex Localization Regulation Of Postsynaptic Membrane Neurotransmitter Receptor Levels L-amino Acid Transport Wound Healing Body Fluid Secretion Neuromuscular Junction Protein Localization To Cell Junction Positive Regulation Of MAPK Cascade Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Establishment Of Planar Polarity Involved In Nephron Morphogenesis	Endoplasmic Reticulum Membrane Endoplasmic Reticulum Membrane Negative Regulation Of Membrane Potential Negative Regulation Of Mitochondrial Membrane Potential Mitochondrial Membrane Organization Membrane Organization Myelin Sheath Mitochondrial Outer Membrane Mitochondrion Organization Mitochondrial Outer Membrane Permeabilization Mitochondrial Protein Catabolic Process Regulation Of Mitochondrial Membrane Permeability Structural Constituent Of Myelin Sheath Regulation Of Membrane Permeability Central Nervous System Myelination Regulation Of Mitochondrial Membrane Potential Positive Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Mitochondrial Envelope Mitochondrial Outer Membrane Permeabilization Involved In Programmed Cell Death Response To Oxidative Stress Negative Regulation Of Mitochondrial Membrane Permeability Negative Regulation Of Membrane Permeability Regulation Of Mitochondrial Membrane Permeability Involved In Apoptotic Process Positive Regulation Of Mitochondrial Membrane Permeability Glial Cell Migration
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