TMEM62 and LTA4H

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TMEM62	LTA4H
Description		transmembrane protein 62	leukotriene A4 hydrolase
Image		No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Hydrolase Activity	RNA Binding Aminopeptidase Activity Epoxide Hydrolase Activity Leukotriene-A4 Hydrolase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Zinc Ion Binding Hydrolase Activity Tripeptide Aminopeptidase Activity Metal Ion Binding Metalloaminopeptidase Activity
	Biological Process		Proteolysis Lipid Metabolic Process Leukotriene Metabolic Process Response To Zinc Ion Leukotriene Biosynthetic Process Protein Metabolic Process Peptide Catabolic Process Response To Peptide Hormone Type I Pneumocyte Differentiation
Pathways			Synthesis of Leukotrienes (LT) and Eoxins (EX) Neutrophil degranulation Biosynthesis of D-series resolvins Biosynthesis of protectins Biosynthesis of E-series 18(S)-resolvins Biosynthesis of aspirin-triggered D-series resolvins Biosynthesis of E-series 18(R)-resolvins
Drugs			Captopril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine 3-(Benzyloxy)Pyridin-2-Amine Imidazole Ubenimex DG051 5-[2-(1H-pyrrol-1-yl)ethoxy]-1H-indole N-(pyridin-3-ylmethyl)aniline (4-fluorophenyl)(pyridin-4-yl)methanone 1-(2,2'-bithiophen-5-yl)methanamine N-[4-(benzyloxy)phenyl]glycinamide (2S)-2-amino-5-oxo-5-[(4-phenylmethoxyphenyl)amino]pentanoic acid 4-amino-N-[4-(benzyloxy)phenyl]butanamide N-methyl-1-(2-thiophen-2-ylphenyl)methanamine {4-[(2R)-pyrrolidin-2-ylmethoxy]phenyl}(4-thiophen-3-ylphenyl)methanone (R)-pyridin-4-yl[4-(2-pyrrolidin-1-ylethoxy)phenyl]methanol 1-(4-thiophen-2-ylphenyl)methanamine N-benzyl-4-[(2R)-pyrrolidin-2-ylmethoxy]aniline 4-(2-amino-1,3-thiazol-4-yl)phenol Kelatorphan 5-[2-(4-hydroxyphenyl)ethyl]benzene-1,3-diol Tosedostat
Diseases
GWAS			Blood protein levels ( 30072576) Diffusing capacity of carbon monoxide ( 30694715) Height ( 20966902) Refractive error ( 32231278) Small intestine neuroendocrine tumor ( 27492634) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		8 interacting genes: APEH CSE1L F2RL1 HSPA5 LTA4H PTPN6 SLC27A6 ZNF287	3 interacting genes: ARPC3 TINF2 TMEM62
Entrez ID		80021	4048
HPRD ID		08669	01056
Ensembl ID		ENSG00000137842	ENSG00000111144
Uniprot IDs		Q0P6H9	A0A140VK27 P09960
PDB IDs			1GW6 1H19 1HS6 1SQM 2R59 2VJ8 3B7R 3B7S 3B7T 3B7U 3CHO 3CHP 3CHQ 3CHR 3CHS 3FH5 3FH7 3FH8 3FHE 3FTS 3FTU 3FTV 3FTW 3FTX 3FTY 3FTZ 3FU0 3FU3 3FU5 3FU6 3FUD 3FUE 3FUF 3FUH 3FUI 3FUJ 3FUK 3FUL 3FUM 3FUN 3U9W 4DPR 4L2L 4MKT 4MS6 4R7L 4RSY 4RVB 5AEN 5BPP 5FWQ 5N3W 5NI2 5NI4 5NI6 5NIA 5NID 5NIE 6ENB 6ENC 6END 6O5H 7AUZ 7AV0 7AV1 7AV2 7KZE 7LLQ 8AVA 8AWH 8QOW 8QPN 8QQ4 8RX3 8RX7 8RX9 8TWX
Enriched GO Terms of Interacting Partners?		Neutrophil Activation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Protein Folding In Endoplasmic Reticulum Leukotriene-A4 Hydrolase Activity Tripeptide Aminopeptidase Activity Tertiary Granule Lumen Epididymis Development Ficolin-1-rich Granule Lumen Extracellular Exosome Omega Peptidase Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cerebellum Structural Organization Cell Activation Involved In Immune Response Mature Conventional Dendritic Cell Differentiation Regulation Of Interleukin-6 Production Leukocyte Activation Involved In Immune Response Leukocyte Proliferation Myeloid Leukocyte Activation Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Regulation Of ATF6-mediated Unfolded Protein Response CD27 Signaling Pathway Negative Regulation Of Mast Cell Activation Involved In Immune Response	Growth Cone Leading Edge Perinucleolar Chromocenter Arp2/3 Protein Complex Actin Polymerization-dependent Cell Motility Nuclear Telomere Cap Complex Shelterin Complex Telomere Assembly Protein Localization To Chromosome, Telomeric Region Telomere Capping Actin Nucleation Filamentous Actin Regulation Of Synaptic Vesicle Endocytosis Arp2/3 Complex-mediated Actin Nucleation Regulation Of Synaptic Vesicle Recycling Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Response To Nerve Growth Factor Cellular Response To Nerve Growth Factor Stimulus Regulation Of Telomere Maintenance Via Telomerase
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