TMEM62 and APEH

Number of citations: 0 (PubMedID 16169070)
Data Source: HPRD (two hybrid)

		TMEM62	APEH
Name		transmembrane protein 62	acylaminoacyl-peptide hydrolase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Membrane	Extracellular Region Cytoplasm Cytosol Nuclear Membrane Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Binding Hydrolase Activity	RNA Binding Serine-type Endopeptidase Activity Protein Binding Peptidase Activity Serine-type Peptidase Activity Omega Peptidase Activity Hydrolase Activity Identical Protein Binding
	Biological Process	None	Translational Termination Proteolysis Amyloid-beta Metabolic Process
Pathways		None	Neutrophil degranulation Eukaryotic Translation Termination
GWAS		No GWAS studies recorded	Body mass index ( 26426971 ) Brain morphology (min-P) ( 32665545 ) Brain morphology (MOSTest) ( 32665545 ) Cortical surface area (MOSTest) ( 32665545 ) Crohn's disease ( 28067908 ) Extremely high intelligence ( 29520040 ) Feeling tense ( 29500382 ) Feeling worry ( 29500382 ) Household income ( 31844048 ) Inflammatory bowel disease ( 28067908 ) Regular attendance at a gym or sports club ( 29970889 ) Regular attendance at a religious group ( 29970889 ) Sleep duration (short sleep) ( 30846698 ) Subcortical volume (min-P) ( 32665545 ) Subcortical volume (MOSTest) ( 32665545 ) Ulcerative colitis ( 21297633 28067908 )
Interacting Genes		8 interacting genes: APEH CSE1L F2RL1 HSPA5 LTA4H PTPN6 SLC27A6 ZNF287	7 interacting genes: CEBPA IST1 LGALS8 RUNX1 SHBG TMEM62 UBA5
Entrez ID		80021	327
HPRD ID		08669	00034
Ensembl ID		ENSG00000137842	ENSG00000164062
Uniprot IDs		Q0P6H9	P13798
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Neutrophil Activation Positive Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Positive Regulation Of Renin Secretion Into Blood Stream Regulation Of Protein Folding In Endoplasmic Reticulum Leukotriene-A4 Hydrolase Activity Tripeptide Aminopeptidase Activity Tertiary Granule Lumen Epididymis Development Ficolin-1-rich Granule Lumen Extracellular Exosome Omega Peptidase Activity Proteinase-activated Receptor Activity Positive Regulation Of Glomerular Filtration Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Eosinophil Degranulation Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Neutrophil Mediated Killing Of Gram-negative Bacterium Cerebellum Structural Organization Cell Activation Involved In Immune Response Mature Conventional Dendritic Cell Differentiation Regulation Of Interleukin-6 Production Leukocyte Activation Involved In Immune Response Leukocyte Proliferation Myeloid Leukocyte Activation Positive Regulation Of Killing Of Cells Of Another Organism Thrombin-activated Receptor Activity Regulation Of ATF6-mediated Unfolded Protein Response CD27 Signaling Pathway Negative Regulation Of Mast Cell Activation Involved In Immune Response	Hematopoietic Stem Cell Proliferation Leukocyte Differentiation Stem Cell Proliferation Regulation Of Proteolysis Positive Regulation Of Cell Activation Myeloid Cell Differentiation RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding UFM1 Activating Enzyme Activity Core-binding Factor Complex Negative Regulation Of Hemopoiesis Regeneration CHOP-C/EBP Complex Response To Vitamin B2 C/EBP Complex Lymphatic Endothelial Cell Migration MIT Domain Binding Cardiac Muscle Tissue Regeneration Positive Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Myeloid Leukocyte Differentiation Regulation Of Cell Activation White Fat Cell Proliferation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Macroautophagy Androgen Binding Protein K69-linked Ufmylation Protein Homodimerization Activity DNA-binding Transcription Factor Binding Regulation Of Multicellular Organismal Process Positive Regulation Of Multicellular Organismal Process Plasma Cell Differentiation Positive Regulation Of Proteolysis Response To Phenylpropanoid Xenophagy Regulation Of CD8-positive, Alpha-beta T Cell Differentiation Positive Regulation Of CD8-positive, Alpha-beta T Cell Activation Positive Regulation Of Granulocyte Differentiation Fat Cell Proliferation Regulation Of Cell Development Protein Domain Specific Binding Positive Regulation Of Cell Differentiation Negative Regulation Of Granulocyte Differentiation ESCRT III Complex Disassembly ESCRT Complex Disassembly Ubiquitin-like Modifier Activating Enzyme Activity Protein Ufmylation Transcription Cis-regulatory Region Binding Positive Regulation Of T Cell Activation Peripheral Nervous System Neuron Development Urea Cycle