PHC3 and HYPK

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PHC3	HYPK
Description		polyhomeotic homolog 3	huntingtin interacting protein K
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Nucleus Nucleoplasm Cytoplasm Microtubule Cytoskeleton Protein-containing Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding	Protein Binding Protein Folding Chaperone
	Biological Process	Negative Regulation Of DNA-templated Transcription	Protein Folding Negative Regulation Of Apoptotic Process Protein Stabilization
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		4 interacting genes: AGR2 H3-4 HYPK OGT	31 interacting genes: BOLL C2orf68 CSNK2B CYSRT1 HNRNPF HTT KRTAP12-2 KRTAP19-5 KRTAP3-2 KRTAP3-3 KRTAP8-1 MAGEA1 MAP1LC3B MDFI NAA10 NAA15 NEDD8 PCBP1 PHC3 PRR20A PRR20B PRR20C PRR20D PRR20E RBFOX1 RHOXF2 SP4 TENT5A THAP1 TXLNA VENTX
Entrez ID		80012	25764
HPRD ID		10149	13724
Ensembl ID		ENSG00000173889	ENSG00000242028
Uniprot IDs		B4E2T1 E7EX82 Q8NDX5	Q9NX55
PDB IDs		4PZN 4PZO	6C95 6PW9 9F1D
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Localization To Membrane Protein O-acetylglucosaminyltransferase Activity Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Transcription By Glucose NSL Complex Dystroglycan Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response	Intermediate Filament NatA Complex N-terminal Protein Amino Acid Acetylation
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