PHC3

Description		polyhomeotic homolog 3
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GO Annotations	Cellular Component	Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Metal Ion Binding
	Biological Process	Negative Regulation Of DNA-templated Transcription
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823)
Interacting Genes		4 interacting genes: AGR2 H3-4 HYPK OGT
Entrez ID		80012
HPRD ID		10149
Ensembl ID		ENSG00000173889
Uniprot IDs		B4E2T1 E7EX82 Q8NDX5
PDB IDs		4PZN 4PZO
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Assembly Spermatogonial Cell Division Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein N-acetylglucosaminyltransferase Complex Non-canonical Inflammasome Complex Assembly Negative Regulation Of Non-canonical Inflammasome Complex Assembly Regulation Of Protein Localization To Cell Periphery Positive Regulation Of Transcription By Glucose Carbon Catabolite Regulation Of Transcription Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Regulation Of Protein Localization To Membrane Protein O-acetylglucosaminyltransferase Activity Lung Goblet Cell Differentiation Positive Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of IRE1-mediated Unfolded Protein Response Regulation Of Transcription By Glucose NSL Complex Dystroglycan Binding Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response
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