COQ8A and STX10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COQ8A	STX10
Description		coenzyme Q8A	syntaxin 10
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GO Annotations	Cellular Component	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane	Golgi Membrane Golgi Apparatus Trans-Golgi Network Cytosol Endomembrane System Membrane Synaptic Vesicle Membrane Organelle Membrane SNARE Complex Vesicle Trans-Golgi Network Membrane Perinuclear Region Of Cytoplasm
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding	SNARE Binding SNAP Receptor Activity Protein Binding Syntaxin Binding
	Biological Process	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation	Intracellular Protein Transport Vesicle Fusion Protein Transport Vesicle-mediated Transport Regulation Of Protein Localization Early Endosome To Golgi Transport Retrograde Transport, Endosome To Golgi Golgi Vesicle Transport Vesicle Docking
Pathways		Ubiquinol biosynthesis	Retrograde transport at the Trans-Golgi-Network
Drugs		Fostamatinib
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS			Appendicular lean mass ( 33097823) Venous thromboembolism ( 31420334)
Interacting Genes		27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC	6 interacting genes: COQ8A CXorf66 STX1A STX4 TMEM101 USP2-AS1
Entrez ID		56997	8677
HPRD ID		07375	04791
Ensembl ID		ENSG00000163050	ENSG00000104915
Uniprot IDs		Q8NI60	O60499 Q5U8S2 X6R2W0
PDB IDs		4PED 5I35 7UDP 7UDQ	4DND
Enriched GO Terms of Interacting Partners?			SNARE Complex Assembly SNARE Complex Positive Regulation Of Regulated Secretory Pathway SNAP Receptor Activity SNARE Binding Vesicle Docking Schaffer Collateral - CA1 Synapse Membrane Docking Neurotransmitter Transport Positive Regulation Of Exocytosis Vesicle Fusion Myosin Head/neck Binding Organelle Localization By Membrane Tethering Sphingomyelin Phosphodiesterase Activator Activity Organelle Membrane Fusion Positive Regulation Of Eosinophil Degranulation Storage Vacuole Positive Regulation Of Synaptic Transmission Organelle Fusion Positive Regulation Of Norepinephrine Secretion Regulation Of Regulated Secretory Pathway Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Neuron Projection Membrane Membrane Fusion Regulation Of Insulin Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Lateral Loop Regulation Of Exocytosis Regulation Of Peptide Hormone Secretion Exocytosis Cornified Envelope Assembly Myelin Sheath Adaxonal Region Extrinsic Component Of Mitochondrial Inner Membrane ATP-dependent Protein Binding Response To Gravity Chloride Channel Inhibitor Activity Actomyosin Regulation Of Hormone Secretion Regulation Of Protein Secretion Endomembrane System Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Regulation Of Norepinephrine Secretion Positive Regulation Of Catecholamine Secretion Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Calcium Channel Inhibitor Activity Specific Granule
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