COQ8A and SMPD2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		COQ8A	SMPD2
Description		coenzyme Q8A	sphingomyelin phosphodiesterase 2
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GO Annotations	Cellular Component	Mitochondrion Membrane Extrinsic Component Of Mitochondrial Inner Membrane Mitochondrial Membrane	Endoplasmic Reticulum Plasma Membrane Caveola Membrane Cell Periphery
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Binding ATP Binding Enzyme Activator Activity Kinase Activity Transferase Activity ADP Binding	Catalytic Activity Sphingomyelin Phosphodiesterase Activity Protein Binding Phosphoric Diester Hydrolase Activity Hydrolase Activity Metal Ion Binding
	Biological Process	Protein Phosphorylation Ubiquinone Biosynthetic Process Phosphorylation	Lipid Metabolic Process Sphingolipid Metabolic Process Ceramide Metabolic Process Sphingomyelin Metabolic Process Sphingomyelin Catabolic Process Response To Mechanical Stimulus Sphingolipid Catabolic Process Intracellular Signal Transduction Ceramide Biosynthetic Process
Pathways		Ubiquinol biosynthesis	Ceramide signalling TNFR1-mediated ceramide production Glycosphingolipid catabolism
Drugs		Fostamatinib
Diseases		Spinocerebellar ataxia (SCA); Machado-Joseph disease (SCA3) Coenzyme Q10 deficiency
GWAS			Height ( 18391951)
Interacting Genes		27 interacting genes: ABHD5 AGTRAP CCDC34 CMTM4 CMTM5 CMTM6 COQ9 DESI2 DTX2 JOSD2 LDAF1 MAL2 MRM1 MTIF3 ORMDL3 PBX3 RABAC1 REEP6 RPRM SH3GLB1 SMPD2 STX10 TFIP11 TMCO2 TMEM239 TPD52L2 UBC	15 interacting genes: ARFIP1 CCN1 COQ8A GAD2 NDRG4 PBX3 PGRMC2 PIK3CG PITPNC1 SLC10A1 SLC7A8 STAR TMEM14B TMEM167B TMEM31
Entrez ID		56997	6610
HPRD ID		07375	04608
Ensembl ID		ENSG00000163050	ENSG00000135587
Uniprot IDs		Q8NI60	O60906
PDB IDs		4PED 5I35 7UDP 7UDQ	8J2F
Enriched GO Terms of Interacting Partners?
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