NXF2 and NUP153

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		NXF2	NUP153
Description		nuclear RNA export factor 2	nucleoporin 153
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear RNA Export Factor Complex	Nucleus Nuclear Envelope Nuclear Pore Nucleoplasm Nucleolus Cytosol Membrane Nuclear Membrane Nuclear Periphery Nuclear Inclusion Body Host Cell Nuclear Pore Nuclear Basket
	Molecular Function	Nucleic Acid Binding RNA Binding Protein Binding	DNA Binding Protein Binding Nuclear Localization Sequence Binding Zinc Ion Binding Structural Constituent Of Nuclear Pore Identical Protein Binding Protein-membrane Adaptor Activity Metal Ion Binding Molecular Condensate Scaffold Activity
	Biological Process	MRNA Export From Nucleus Poly(A)+ MRNA Export From Nucleus RNA Transport MRNA Transport	RNA Export From Nucleus Protein Import Into Nucleus Nucleocytoplasmic Transport Protein Transport Symbiont Entry Into Host Cell Negative Regulation Of RNA Export From Nucleus MRNA Transport Nuclear Pore Complex Assembly Viral Penetration Into Host Nucleus Amyloid Fibril Formation
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript	ISG15 antiviral mechanism Transport of the SLBP independent Mature mRNA Transport of the SLBP Dependant Mature mRNA Transport of Mature mRNA Derived from an Intronless Transcript Transport of Mature mRNA derived from an Intron-Containing Transcript Rev-mediated nuclear export of HIV RNA Transport of Ribonucleoproteins into the Host Nucleus NS1 Mediated Effects on Host Pathways Viral Messenger RNA Synthesis NEP/NS2 Interacts with the Cellular Export Machinery Regulation of Glucokinase by Glucokinase Regulatory Protein Nuclear import of Rev protein Vpr-mediated nuclear import of PICs IPs transport between nucleus and cytosol IP3 and IP4 transport between cytosol and nucleus IP6 and IP7 transport between cytosol and nucleus snRNP Assembly SUMOylation of DNA damage response and repair proteins SUMOylation of ubiquitinylation proteins Nuclear Pore Complex (NPC) Disassembly Regulation of HSF1-mediated heat shock response SUMOylation of SUMOylation proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins Transcriptional regulation by small RNAs Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) tRNA processing in the nucleus HCMV Early Events HCMV Late Events SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS			Femur bone mineral density x serum urate levels interaction ( 34046847) Height ( 18391951) Obesity-related traits ( 23251661)
Interacting Genes		12 interacting genes: ALG13 APEX1 APP HNRNPUL1 MAP1A MAP1B NUP153 NUP214 NUP62 NXF1 NXT1 NXT2	29 interacting genes: APC BRCA1 CEBPA CLK1 DNMT3A DYNLT1 FILNC1 GRSF1 IPO5 KPNA2 KPNB1 MAPK1 MAPK14 MAPK3 NUP62 NXF1 NXF2 PTGER4 RAN SENP2 SMAD2 SMAD3 TNPO1 TPR TRN-GTT2-7 XPO1 XPO5 XPO7 XPOT
Entrez ID		56001	9972
HPRD ID		02260	04899
Ensembl ID		ENSG00000269405	ENSG00000124789
Uniprot IDs		Q9GZY0	P49790
PDB IDs			2EBQ 2EBR 2EBV 2GQE 4U0C 4U0D 5TSV 5TSX 6AYA 8CKY 8CL0 9CNU
Enriched GO Terms of Interacting Partners?		RNA Export From Nucleus MRNA Transport Nuclear Export RNA Transport Nuclear Pore Nucleobase-containing Compound Transport Nuclear Pore Central Transport Channel Intracellular Transport Nuclear Transport Nucleocytoplasmic Transport Nuclear RNA Export Factor Complex Cellular Localization Establishment Of Localization In Cell MRNA Export From Nucleus Structural Constituent Of Nuclear Pore Poly(A)+ MRNA Export From Nucleus PTB Domain Binding Protein Transport Dendrite Development Establishment Of Protein Localization Nuclear Envelope Intracellular Protein Transport Nuclear Inclusion Body Neuron Projection Maintenance Intracellular Protein Localization Protein Import Into Nucleus Import Into Nucleus Nuclear Localization Sequence Binding Axonogenesis Amyloid Fibril Formation Regulation Of Microtubule Cytoskeleton Organization Transport Along Microtubule Protein Localization To Nucleus Protein Export From Nucleus Cytoskeleton-dependent Intracellular Transport Regulation Of Microtubule Depolymerization Microtubule Associated Complex Regulation Of Synaptic Plasticity Dendritic Shaft Neuron Projection Organization Microtubule-based Transport Positive Regulation Of Gene Expression, Epigenetic Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Telomere Maintenance Via Base-excision Repair Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway	Nuclear Transport Nucleocytoplasmic Transport Nuclear Pore RNA Transport Nuclear Export RNA Export From Nucleus Nucleobase-containing Compound Transport Protein Transport Establishment Of Protein Localization Regulation Of Intracellular Transport Protein Localization To Nucleus Intracellular Protein Transport Protein Import Into Nucleus Nucleoplasm Import Into Nucleus Protein Export From Nucleus Intracellular Transport Nuclear Export Signal Receptor Activity Positive Regulation Of Protein Import Into Nucleus Intracellular Protein Localization Establishment Of Localization In Cell RNA Import Into Nucleus Nuclear Import Signal Receptor Activity Regulation Of Nucleocytoplasmic Transport Nuclear Localization Sequence Binding Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Nuclear Envelope MRNA Transport RNA Binding Cellular Localization Positive Regulation Of Intracellular Transport Regulation Of Intracellular Protein Transport Regulation Of Cellular Localization Nuclear Membrane Positive Regulation Of Intracellular Protein Transport Small GTPase Binding Cellular Response To Tumor Necrosis Factor Positive Regulation Of Protein Localization To Nucleus Nucleus Establishment Of Protein Localization To Organelle Phosphatase Binding Response To Tumor Necrosis Factor Regulation Of Ossification MAP Kinase Activity RNA Nuclear Export Complex Pre-miRNA Export From Nucleus Regulation Of Cytoskeleton Organization MRNA Export From Nucleus Cytoplasm
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