SP7 and TRIM62

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SP7	TRIM62
Description		Sp7 transcription factor	tripartite motif containing 62
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Cytoplasm	Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding DEAD/H-box RNA Helicase Binding Metal Ion Binding	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Osteoblast Differentiation Regulation Of Transcription By RNA Polymerase II Gene Expression Response To Insulin Cellular Response To Zinc Ion Starvation Positive Regulation Of Transcription By RNA Polymerase II Hematopoietic Stem Cell Differentiation Diphosphate Metabolic Process Cementum Mineralization Positive Regulation Of Stem Cell Differentiation	Immune System Process Negative Regulation Of Epithelial To Mesenchymal Transition Protein Ubiquitination Viral Release From Host Cell Negative Regulation Of Viral Transcription Positive Regulation Of Canonical NF-kappaB Signal Transduction Protein K27-linked Ubiquitination Innate Immune Response Positive Regulation Of DNA-templated Transcription Regulation Of Viral Entry Into Host Cell Positive Regulation Of Antifungal Innate Immune Response
Pathways		RUNX2 regulates osteoblast differentiation	Interferon gamma signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Bone mineral density (spine) ( 19079262 19801982) HDL cholesterol levels ( 32203549) Heel bone mineral density ( 30598549) Height ( 31562340) Hypospadias (moderate to severe) ( 31856834) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420) Mean corpuscular hemoglobin ( 29403010 32888494) Mean corpuscular volume ( 32888494) Serum alkaline phosphatase levels ( 33547301) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Gut microbiota (beta diversity) ( 27723756)
Interacting Genes		11 interacting genes: CBL CBLB DRC4 FAM124B FBXW7 HNF1B MAPK14 NFIC NFIX QARS1 TRIM62	19 interacting genes: CARD9 EAF1 EPN2 EXOSC5 FAIM GLRX PPP1R18 SKIL SMAD2 SP7 TBC1D7 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E3 UBE2L6 UBXN7 UTP25
Entrez ID		121340	55223
HPRD ID		05971	07697
Ensembl ID		ENSG00000170374	ENSG00000116525
Uniprot IDs		Q8TDD2	Q9BVG3
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of ERBB Signaling Pathway Positive Regulation Of ERBB Signaling Pathway Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Cell Communication Regulation Of Signaling Ubiquitin-protein Transferase Activity Protein Ubiquitination Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of DNA-templated Transcription Mesonephric Duct Formation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Mesonephric Nephron Morphogenesis Ureteric Bud Elongation Pronephric Nephron Tubule Development Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Receptor Tyrosine Kinase Binding Macromolecule Metabolic Process Protein Modification By Small Protein Conjugation Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Signal Transduction Post-translational Protein Modification Ubiquitin Protein Ligase Activity Animal Organ Development Regulation Protein Catabolic Process At Postsynapse Cellular Response To UV Negative Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Macromolecule Biosynthetic Process Regulation Of Synaptic Membrane Adhesion Cis-regulatory Region Sequence-specific DNA Binding Glutamine-tRNA Ligase Activity Glutaminyl-tRNA Aminoacylation Regulation Of Branch Elongation Involved In Ureteric Bud Branching Mesonephric Duct Morphogenesis Hepatoblast Differentiation Negative Regulation Of Mesenchymal Cell Apoptotic Process Involved In Metanephros Development Regulation Of Pronephros Size Positive Regulation Of Antifungal Innate Immune Response Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex Negative Regulation Of Hepatocyte Proliferation Phosphothreonine Residue Binding Negative Regulation Of Cell Communication	Ubiquitin Conjugating Enzyme Activity Protein K48-linked Ubiquitination Ubiquitin-protein Transferase Activity Protein Polyubiquitination Regulation Of BMP Signaling Pathway Macromolecule Catabolic Process Negative Regulation Of Cellular Response To Growth Factor Stimulus Protein K11-linked Ubiquitination Regulation Of Cellular Response To Growth Factor Stimulus Modification-dependent Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Protein K6-linked Ubiquitination Catabolic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Nucleoplasm Nucleus Protein-containing Complex SMAD Binding Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Proteolysis Phosphatase Binding Macromolecule Metabolic Process Protein Monoubiquitination Glutathione Disulfide Oxidoreductase Activity Homomeric SMAD Protein Complex TSC1-TSC2 Complex Binding Negative Regulation Of TORC1 Signaling Cellular Response To Nutrient Levels Protein Autoubiquitination Zygotic Specification Of Dorsal/ventral Axis Activin Responsive Factor Complex Paraxial Mesoderm Morphogenesis Negative Regulation Of Signal Transduction Protein K63-linked Ubiquitination TSC1-TSC2 Complex
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