MOB3B and ST3GAL3

Data Source: HiPPIP (Novel)

		MOB3B	ST3GAL3
Name		MOB kinase activator 3B	ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm	Golgi Membrane Extracellular Region Golgi Apparatus Membrane Golgi Cisterna Membrane
	Molecular Function	Protein Binding Protein Kinase Activator Activity Metal Ion Binding	Beta-galactoside (CMP) Alpha-2,3-sialyltransferase Activity Protein Binding N-acetyllactosaminide Alpha-2,3-sialyltransferase Activity Sialyltransferase Activity Transferase Activity Glycosyltransferase Activity
	Biological Process	Signal Transduction Regulation Of Hippo Signaling	Protein Glycosylation Glycosphingolipid Biosynthetic Process Oligosaccharide Biosynthetic Process Ganglioside Biosynthetic Process Via Lactosylceramide Protein O-linked Glycosylation Via N-acetyl-galactosamine Keratan Sulfate Proteoglycan Biosynthetic Process Viral Protein Processing
Pathways		None	Pre-NOTCH Processing in Golgi Keratan sulfate biosynthesis Defective ST3GAL3 causes MCT12 and EIEE15 Sialic acid metabolism Lewis blood group biosynthesis Maturation of protein 3a Maturation of spike protein Maturation of protein 3a Termination of O-glycan biosynthesis Glycosphingolipid biosynthesis
Diseases		None	Nonsyndromic autosomal recessive mental retardation (NS-ARMR)
GWAS		Adult asthma ( 27611488 ) Asthma ( 27611488 ) Delirium ( 29631748 ) Plasma trimethylamine N-oxide levels ( 28439531 ) Urinary symptoms in response to radiotherapy in prostate cancer ( 23376709 )	Age at first birth ( 34211149 ) Age at first sexual intercourse ( 34211149 ) Aging (time to event) ( 21782286 ) Amyotrophic lateral sclerosis (age of onset) ( 22959728 ) Attention deficit hyperactivity disorder ( 29325848 ) Autism spectrum disorder or schizophrenia ( 28540026 ) Cognitive ability ( 29186694 ) Cognitive ability (MTAG) ( 29186694 ) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444 ) General cognitive ability ( 29844566 ) Household income ( 31844048 ) Household income (MTAG) ( 31844048 ) Intelligence (MTAG) ( 29326435 ) Left-handedness ( 32989287 ) Monocyte percentage of white cells ( 32888494 ) Non-lobar intracerebral hemorrhage (MTAG) ( 31430377 ) Refractive error ( 32231278 ) Schizophrenia ( 28991256 ) Serum alkaline phosphatase levels ( 33547301 )
Novel Interactors		1 novel interactors: ST3GAL3	14 novel interactors: CAVIN2 EIF2B3 FBLN5 HDAC5 KCNQ4 KDM4A LASP1 MOB3B NASP PIK3R3 POU3F1 RRM2 TGFB1I1 VTI1A
Interacting Genes		6 interacting genes: LATS1 LATS2 MAPK14 NT5C2 PPBP STK3	5 interacting genes: ACTG1 RPL8 SCAMP2 TTR ZBTB5
Entrez ID		79817	6487
HPRD ID		14728	05930
Ensembl ID		ENSG00000120162	ENSG00000126091
Uniprot IDs		Q86TA1	A0A2R8Y6H4 A0A2R8Y6L4 A0A2R8Y732 A0A2R8YDJ6 Q11203
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Regulation Of Hippo Signaling Regulation Of Organ Growth Positive Regulation Of Hippo Signaling Negative Regulation Of Canonical Wnt Signaling Pathway Hippo Signaling Negative Regulation Of Wnt Signaling Pathway Inner Cell Mass Cell Fate Commitment Inner Cell Mass Cellular Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Regulation Of Wnt Signaling Pathway Regulation Of Developmental Growth Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Serine Kinase Activity Transferase Activity Negative Regulation Of Cyclin-dependent Protein Kinase Activity Protein Serine/threonine Kinase Activity Regulation Of Protein Localization To Nucleus Protein Kinase Activity Spindle Pole Cell Morphogenesis Regulation Of Growth D-glucose Transmembrane Transport Kinase Activity ATP Binding Hexose Transmembrane Transport Canonical Inflammasome Complex Assembly Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of NLRP3 Inflammasome Complex Assembly Protein Metabolic Process Carbohydrate Transmembrane Transport Protein Modification Process Carbohydrate Transport Negative Regulation Of Protein Localization To Nucleus Regulation Of NLRP3 Inflammasome Complex Assembly Nucleotide Binding Protein Phosphorylation Negative Regulation Of Cell Cycle Keratinocyte Differentiation Positive Regulation Of Fat Cell Differentiation Phosphorylation Negative Regulation Of Protein Kinase Activity Nucleoside Phosphotransferase Activity GMP Catabolic Process To Guanine Negative Regulation Of Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle G1/S Phase Transition Epidermal Cell Differentiation Canonical Wnt Signaling Pathway Negative Regulation Of Protein Phosphorylation	None