TXNDC15 and HLCS

Number of citations: 83 (PubMedID 35914814)
Data Source: BioGRID (two hybrid)

		TXNDC15	HLCS
Name		thioredoxin domain containing 15	holocarboxylase synthetase
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cilium Membrane Cell Projection Ciliary Membrane	Chromatin Nuclear Lamina Cytoplasm Mitochondrion Cytosol Nuclear Matrix
	Molecular Function	Protein Binding	Nucleotide Binding Catalytic Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Protein Binding ATP Binding Biotin Binding Ligase Activity Enzyme Binding Identical Protein Binding
	Biological Process	Cell Projection Organization Positive Regulation Of Smoothened Signaling Pathway Cilium Assembly	Biotin Metabolic Process Post-translational Protein Modification Response To Biotin
Pathways		None	Biotin transport and metabolism Defective HLCS causes multiple carboxylase deficiency
Drugs		None	Biotin
Diseases		None	Holocarboxylase synthetase deficiency
GWAS		Blood protein levels ( 30072576 ) Height ( 18391951 )	Developmental language disorder ( 27016271 ) Developmental language disorder (linguistic errors) ( 27016271 ) Hematocrit ( 32888494 ) Hemoglobin ( 32888494 ) Intracranial aneurysm ( 29531279 ) Night sleep phenotypes ( 27126917 ) Red blood cell count ( 32888494 ) Seasonality and depression ( 30217971 )
Novel Interactors		None recorded	9 novel interactors: BACH1 IFNAR2 IFNGR2 IFT20 LANCL2 NGB SOD1 TGM3 WIPF1
Interacting Genes		4 interacting genes: ASPH HLCS UBC ZDHHC17	10 interacting genes: ACACB ANKRD29 DDX52 KRTAP5-9 MED19 POT1 QKI SARS2 SNX27 TXNDC15
Entrez ID		79770	3141
HPRD ID		08658	08360
Ensembl ID		ENSG00000113621	ENSG00000159267
Uniprot IDs		Q96J42	A0A8C8QSB1 P50747
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Peptidyl-aspartic Acid 3-dioxygenase Activity Biotin--[biotin Carboxyl-carrier Protein] Ligase Activity Response To Biotin Postsynaptic Golgi Apparatus Regulation Of Modification Of Synapse Structure, Modulating Synaptic Transmission Perforant Pathway To Dendrate Granule Cell Synapse Regulation Of Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Activation Of Store-operated Calcium Channel Activity Biotin Metabolic Process Biotin Binding Protein-cysteine S-myristoyltransferase Activity Positive Regulation Of Store-operated Calcium Channel Activity Protein-cysteine S-stearoyltransferase Activity Cortical Endoplasmic Reticulum Sarcoplasmic Reticulum Lumen Junctional Sarcoplasmic Reticulum Membrane Positive Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Cell Communication By Electrical Coupling Regulation Of Calcium Ion Transport Into Cytosol Detection Of Calcium Ion Protein Modification Process Nuclear Lamina Protein Tag Activity Lipoprotein Transport Regulation Of Neurotrophin TRK Receptor Signaling Pathway Protein Palmitoylation Palmitoyltransferase Activity Regulation Of Modification Of Synaptic Structure Golgi-associated Vesicle Membrane Protein-cysteine S-palmitoyltransferase Activity Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Positive Regulation Of Cation Channel Activity Calcium Channel Complex	None