RNASEH2B and WT1

Number of citations of the paper that reports this interaction (PubMedID 27229929)
45

Data Source:
BioGRID (two hybrid)

		RNASEH2B	WT1
Description		ribonuclease H2 subunit B	WT1 transcription factor
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Ribonuclease H2 Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding Metal Ion Binding C2H2 Zinc Finger Domain Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	In Utero Embryonic Development Nucleobase-containing Compound Metabolic Process Mismatch Repair RNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Gene Expression Negative Regulation Of Gene Expression Fibroblast Proliferation Positive Regulation Of Fibroblast Proliferation Regulation Of DNA Damage Checkpoint	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Translation Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Nephron Tubule Morphogenesis Podocyte Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Circulatory System Development Positive Regulation Of MiRNA Transcription Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development
Pathways			Transcriptional regulation of testis differentiation Negative Regulation of CDH1 Gene Transcription Nephron development
Drugs
Diseases		Aicardi-Goutieres Syndrome (AGS)	Nephrotic syndrome and focal segmental glomerulosclerosis 46,XY disorders of sex development (Disorders of gonadal development), including: Gonadal agenesis; Complete and partial gonadal dysgenesis; Testis regression; Ovotesticular DSD
GWAS		Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Metabolite levels ( 23823483) Rheumatoid arthritis (ACPA-negative) ( 24532677) Systolic blood pressure ( 30224653)	Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Brugada syndrome ( 35210625) Coronary artery disease ( 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pelvic organ prolapse ( 32184442) PR interval ( 32439900) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31649266 31249589 30194396) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		2 interacting genes: WT1 ZBTB14	66 interacting genes: AREG BHLHE40 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FMR1NB GLIS2 GOLGA2 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP YAP1 ZNF205 ZRANB1
Entrez ID		79621	7490
HPRD ID		07757	06163
Ensembl ID		ENSG00000136104	ENSG00000184937
Uniprot IDs		A0A087WXR7 A0A2R8Y883 Q5TBB1 Q8N451	A0A481V744 H0Y7K5 P19544 Q6PI38
PDB IDs		3P56 3P87 3PUF 8YJZ	1XF7 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH 7BBG 8ISN
Enriched GO Terms of Interacting Partners?		Kidney Development Transcription Cis-regulatory Region Binding Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Adrenal Cortex Formation Positive Regulation Of Metanephric Ureteric Bud Development Visceral Serous Pericardium Development Posterior Mesonephric Tubule Development Negative Regulation Of Female Gonad Development Negative Regulation Of Glomerular Mesangial Cell Proliferation Hemi-methylated DNA-binding Metanephric S-shaped Body Morphogenesis Negative Regulation Of Cell Proliferation Involved In Kidney Development Thorax And Anterior Abdomen Determination Double-stranded Methylated DNA Binding Diaphragm Development Regulation Of Female Gonad Development Sequence-specific DNA Binding Positive Regulation Of Male Gonad Development S-shaped Body Morphogenesis Cardiac Muscle Cell Fate Commitment Metanephric Mesenchyme Development Sequence-specific Double-stranded DNA Binding Metanephric Epithelium Development Muscle Cell Fate Commitment Nephron Tubule Morphogenesis Negative Regulation Of Gene Expression Via Chromosomal CpG Island Methylation Glomerulus Development Podocyte Differentiation C2H2 Zinc Finger Domain Binding Glomerular Basement Membrane Development Regulation Of Glomerular Mesangial Cell Proliferation DNA-binding Transcription Factor Activity Male Genitalia Development Mesenchymal To Epithelial Transition Renal Tubule Morphogenesis Skeletal Muscle Organ Development Cellular Response To Gonadotropin Stimulus Circulatory System Development Sex Determination Reproductive System Development Adrenal Gland Development Heart Valve Development Nucleolus Coronary Vasculature Development Response To Gonadotropin Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Animal Organ Formation Cell Differentiation Involved In Kidney Development Aggresome	Keratin Filament Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Intermediate Filament Negative Regulation Of Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Biosynthetic Process P53 Binding Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nuclear Body Nucleoplasm Regulation Of Transcription By RNA Polymerase II Cellular Response To Gamma Radiation Cellular Response To Radiation Chromatin Identical Protein Binding Epithelial Cell Proliferation Regulation Of Stem Cell Population Maintenance Regulation Of Somatic Stem Cell Population Maintenance MDM2/MDM4 Family Protein Binding Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Primary Metabolic Process Positive Regulation Of Signal Transduction Cellular Response To UV Regulation Of RNA Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cellular Response To Actinomycin D Cell Population Proliferation Positive Regulation Of Lymphocyte Apoptotic Process Nucleus Regulation Of Intracellular Signal Transduction Regulation Of Gene Expression Signal Transduction By P53 Class Mediator Response To Gamma Radiation Transcription Factor Binding Regulation Of Metabolic Process Regulation Of Signal Transduction DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Positive Regulation Of MiRNA Transcription Cytosol Cellular Response To Light Stimulus Response To Actinomycin D PML Body
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