RIC3 and TMBIM1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		RIC3	TMBIM1
Description		RIC3 acetylcholine receptor chaperone	transmembrane BAX inhibitor motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Neuron Projection Neuronal Cell Body Intracellular Membrane-bounded Organelle Synapse	Golgi Membrane Lysosome Lysosomal Membrane Endosome Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Endosome Membrane Membrane Specific Granule Membrane Extracellular Exosome
	Molecular Function	Protein Binding Acetylcholine Receptor Binding Protein Folding Chaperone	Death Receptor Binding Calcium Channel Activity Protein Binding
	Biological Process	Protein Folding Positive Regulation Of Cytosolic Calcium Ion Concentration Synaptic Transmission, Cholinergic Protein Localization To Cell Surface Protein-containing Complex Assembly Positive Regulation Of Protein Localization To Cell Surface	Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Calcium Ion Transmembrane Transport Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling
Pathways			Neutrophil degranulation
Drugs		Theophylline
Diseases
GWAS		Blood protein levels ( 30072576) Body mass index ( 26426971) Body mass index (age <50) ( 26426971) Body mass index x sex x age interaction (4df test) ( 26426971) Malaria ( 31844061)	Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) Glycated hemoglobin levels ( 34059833) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 23128233 28067908) Red cell distribution width ( 27863252) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		16 interacting genes: BCL2L1 CACNA1C CLN6 FA2H FATE1 GOSR2 NINJ2 PRB1 STX12 STX7 TMBIM1 TMEFF2 TMEM11 TMEM86A TRAF3IP3 YIF1A	13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63
Entrez ID		79608	64114
HPRD ID		17974	17884
Ensembl ID		ENSG00000166405	ENSG00000135926
Uniprot IDs		A0A0S2Z607 A0A0S2Z6D3 B7Z3Z0 Q7Z5B4	B3KSM0 B4DUD2 Q969X1
PDB IDs
Enriched GO Terms of Interacting Partners?		Membrane SNARE Complex SNAP Receptor Activity Membrane Organization Endoplasmic Reticulum SNARE Binding Vesicle Fusion Organelle Membrane Fusion Regulation Of Protein Localization To Plasma Membrane Organelle Fusion Golgi Membrane Endoplasmic Reticulum Membrane Regulation Of Protein Localization To Cell Periphery Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Protein Localization To Plasma Membrane Membrane Fusion Regulation Of Protein Localization To Membrane Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Apoptotic Process In Bone Marrow Cell Mitochondrial Outer Membrane Negative Regulation Of Integrin Biosynthetic Process 4-hydroxysphinganine Ceramide Fatty Acyl 2-hydroxylase Activity Free Fatty Acid 2-hydroxylase Activity Fatty Acid 2-hydroxylase Activity Glycosphingolipid Metabolic Process Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Endomembrane System Vesicle Docking Negative Regulation Of Fas Signaling Pathway Sebaceous Gland Cell Differentiation Glucosylceramide Biosynthetic Process Regulation Of Sebum Secreting Cell Proliferation Regulation Of Acinar Cell Proliferation Alkenylglycerophosphocholine Hydrolase Activity Dendritic Cell Proliferation Dendritic Cell Apoptotic Process Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Calcium Channel Activity Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Vesicle Organization Tertiary Granule Organelle Localization By Membrane Tethering Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Central Nervous System Myelin Maintenance Membrane Docking Vesicle-mediated Transport Membrane Destabilizing Activity Positive Regulation Of Receptor Localization To Synapse Glycolipid Metabolic Process
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