RNF219 and CTNNA1

Number of citations of the paper that reports this interaction (PMID 20936779)
48

Data Source:
BioGRID (two hybrid)

		RNF219	CTNNA1
Gene Name		ring finger protein 219	catenin (cadherin-associated protein), alpha 1, 102kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component		Acrosomal Vesicle Cytosol Plasma Membrane Cell-cell Junction Zonula Adherens Focal Adhesion Intercalated Disc Actin Cytoskeleton Catenin Complex Lamellipodium
	Molecular Function	Zinc Ion Binding	Structural Molecule Activity Protein Binding Beta-catenin Binding Vinculin Binding Poly(A) RNA Binding Gamma-catenin Binding Cadherin Binding Actin Filament Binding
	Biological Process	Positive Regulation Of MRNA Splicing, Via Spliceosome	Ovarian Follicle Development Actin Filament Organization Cell Adhesion Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Neuroblast Proliferation Aging Male Gonad Development Gap Junction Assembly Axon Regeneration Cell Junction Assembly Adherens Junction Organization Cellular Protein Localization Odontogenesis Of Dentin-containing Tooth Muscle Cell Differentiation Apical Junction Assembly Response To Estrogen Cell-cell Junction Organization Positive Regulation Of Smoothened Signaling Pathway Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Muscle Cell Differentiation Protein Heterooligomerization Cellular Response To Indole-3-methanol Epithelial Cell-cell Adhesion Negative Regulation Of Cell Motility Negative Regulation Of Integrin-mediated Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways			Cell junction organization Cell-cell junction organization CDO in myogenesis Myogenesis Signaling by VEGF Adherens junctions interactions VEGFR2 mediated vascular permeability VEGFA-VEGFR2 Pathway
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: CTNNA1 TCEANC	27 interactors: ACTN1 AJUBA APC APP ARMC8 CA9 CDH1 CDH15 CDH2 CDH3 CDH5 CTBP1 CTNNB1 DLG1 FAM84B JUP MLLT4 PKD1 PSEN1 RNF219 SPTAN1 SPTBN1 SUMO1 TJP1 TJP2 VCL ZGPAT
Entrez ID		79596	1495
HPRD ID		12619	00285
Ensembl ID		ENSG00000152193	ENSG00000044115
Uniprot IDs		Q5W0B1	P35221
PDB IDs			1H6G 4EHP 4IGG
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Integrin-mediated Signaling Pathway Cellular Response To Indole-3-methanol Gap Junction Assembly Negative Regulation Of Neuroblast Proliferation Epithelial Cell-cell Adhesion Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Stem Cell Proliferation Regulation Of Integrin-mediated Signaling Pathway Axon Regeneration Positive Regulation Of Smoothened Signaling Pathway Neuron Projection Regeneration Negative Regulation Of Neural Precursor Cell Proliferation Regulation Of Neuroblast Proliferation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Response To Axon Injury Regulation Of DNA-templated Transcription, Elongation Ovarian Follicle Development Apical Junction Assembly Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Regulation Of Smoothened Signaling Pathway Ovulation Cycle Process Positive Regulation Of Muscle Cell Differentiation Adherens Junction Organization Odontogenesis Of Dentin-containing Tooth Regulation Of Neural Precursor Cell Proliferation Female Gonad Development Ovulation Cycle Regulation Of Stem Cell Proliferation Development Of Primary Female Sexual Characteristics Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell-cell Junction Assembly	Cell Junction Assembly Cell-cell Junction Organization Adherens Junction Organization Cell Adhesion Cellular Component Assembly Epithelium Development Developmental Process Anatomical Structure Development Cell-cell Junction Assembly Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Single Organismal Cell-cell Adhesion Execution Phase Of Apoptosis Adherens Junction Assembly Cell Differentiation Tissue Development Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Cell Development Cellular Response To Indole-3-methanol Establishment Of Endothelial Barrier Apical Junction Assembly Anatomical Structure Morphogenesis Establishment Of Endothelial Intestinal Barrier Regulation Of Protein Complex Assembly Regulation Of Cellular Process Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Skin Development Regulation Of Signal Transduction Movement Of Cell Or Subcellular Component Endothelial Cell Development Tight Junction Assembly Positive Regulation Of Protein Metabolic Process Locomotion Endomembrane System Organization Neurogenesis Apoptotic Process Regulation Of Epithelial Cell Proliferation Regulation Of Signaling Cell Morphogenesis Involved In Differentiation Programmed Cell Death Morphogenesis Of An Epithelium Cell Death Death Cell-matrix Adhesion Positive Regulation Of Protein Complex Assembly Positive Regulation Of Cellular Protein Metabolic Process Endothelial Cell Differentiation Neuron Differentiation Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Protein Localization
Tagcloud ?		a4 ageing apba2 apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled sv2a transcriptome transcriptomic unaffected	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Difference) ?		a4 ageing apba2 apoe4 apolipoprotein broadly carrier carriers deposition determinants encode endocytosis epsilon4 fyn implicate influenced initially load mediators modify modulators physiology pursue referred resembled sv2a transcriptome transcriptomic unaffected	alphae alphat cardiomyocyte cardiomyocytes catenin catenins coactivator contractility cre delete divide dying gained heart hearts injured knockout lose perinatal proof rationale regulators replace shortly transgenes unable yap yes
Tagcloud (Intersection) ?