BHLHE41 and FBXW11

Number of citations of the paper that reports this interaction (PubMedID 23555304)
45

Data Source:
BioGRID (two hybrid)

		BHLHE41	FBXW11
Description		basic helix-loop-helix family member e41	F-box and WD repeat domain containing 11
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Ubiquitin Ligase Complex Kinetochore Nucleus Nuclear Envelope Cytoplasm Centrosome Cytosol Microtubule Associated Complex Cytoplasmic Microtubule SCF Ubiquitin Ligase Complex Neuron Projection Neuronal Cell Body Axon Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	Protein Binding Protein Dimerization Activity Microtubule Plus-end Binding Dynein Complex Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	Establishment Of Mitotic Spindle Orientation Protein Polyubiquitination Protein Dephosphorylation Nuclear Migration Germ Cell Development Retrograde Axonal Transport Wnt Signaling Pathway Protein Ubiquitination Microtubule Organizing Center Organization SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Protein Destabilization Positive Regulation Of Circadian Rhythm Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Positive Regulation Of DNA-templated Transcription Vesicle Transport Along Microtubule Rhythmic Process Brain Morphogenesis
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression	Activation of NF-kappaB in B cells Downstream TCR signaling Regulation of PLK1 Activity at G2/M Transition FCERI mediated NF-kB activation Dectin-1 mediated noncanonical NF-kB signaling CLEC7A (Dectin-1) signaling NIK-->noncanonical NF-kB signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A Neddylation Antigen processing: Ubiquitination & Proteasome degradation Degradation of CRY and PER proteins
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Response to bupropion and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Appendicular lean mass ( 33097823) Height ( 20881960 23563607 25282103 25429064 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for body mass index ( 25673412 28448500 34021172)
Interacting Genes		22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5	29 interacting genes: AGTR1 BHLHE41 BTRC CDC25A CSNK1E CUL1 DAPK1 GLI2 GSK3B IFNAR1 KDR MCL1 MITF NFE2L2 NFKB1 NFKBIA PPP1CC PPP2R1B PPP2R5E PRKACA PRLR PTEN RIPK4 TBC1D4 TFE3 TRIM21 UBE2D3 WEE1 ZNF281
Entrez ID		79365	23291
HPRD ID		16204	07294
Ensembl ID		ENSG00000123095	ENSG00000072803
Uniprot IDs		Q8TAT1 Q9C0J9	B4DH70 E5RGC1 Q9UKB1
PDB IDs			6WNX
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Negative Regulation Of Intracellular Signal Transduction Protein Kinase CK2 Complex Positive Regulation Of Circadian Rhythm Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Glucose Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Regulation Of Metabolic Process Wnt Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity	Positive Regulation Of Metabolic Process Regulation Of Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Cell Differentiation Regulation Of Macromolecule Metabolic Process Positive Regulation Of Catabolic Process Response To Peptide Negative Regulation Of Metabolic Process Response To Cytokine Regulation Of Autophagy Positive Regulation Of Autophagy Nucleus Signal Transduction Intracellular Signaling Cassette Protein Modification Process Nucleoplasm Intracellular Signal Transduction Circadian Rhythm Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Gene Expression Rhythmic Process Cellular Response To Cytokine Stimulus Regulation Of Macromolecule Biosynthetic Process Regulation Of Cell Communication Regulation Of Signaling Regulation Of Signal Transduction Cytosol Cell Surface Receptor Signaling Pathway Positive Regulation Of Nucleobase-containing Compound Metabolic Process I-kappaB/NF-kappaB Complex Positive Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Proteasomal Protein Catabolic Process TOR Signaling Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Protein Metabolic Process Protein Phosphorylation Regulation Of Proteasomal Protein Catabolic Process Non-canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Regulation Of Macrophage Derived Foam Cell Differentiation Cytoplasm Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Positive Regulation Of Signal Transduction Regulation Of Proteolysis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?