BHLHE41

Description		basic helix-loop-helix family member e41
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Response to bupropion and depression ( 27622933) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5
Entrez ID		79365
HPRD ID		16204
Ensembl ID		ENSG00000123095
Uniprot IDs		Q8TAT1 Q9C0J9
PDB IDs
Enriched GO Terms of Interacting Partners?		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Negative Regulation Of Intracellular Signal Transduction Protein Kinase CK2 Complex Positive Regulation Of Circadian Rhythm Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Glucose Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Regulation Of Metabolic Process Wnt Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity
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