BHLHE41 and RORC

Number of citations: 45 (PubMedID 23555304)
Data Source: BioGRID (two hybrid)

		BHLHE41	RORC
Name		basic helix-loop-helix family member e41	RAR related orphan receptor C
Structure		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus	Chromatin Nucleus Nucleoplasm Nuclear Body
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding BHLH Transcription Factor Binding MRF Binding Protein Heterodimerization Activity Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding E-box Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Oxysterol Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding Ligand-modulated Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Circadian Rhythm Anterior/posterior Pattern Specification Negative Regulation Of Myotube Differentiation Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Negative Regulation Of DNA-templated Transcription Rhythmic Process Regulation Of Neurogenesis	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Circadian Rhythm Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Steroid Metabolic Process Intracellular Receptor Signaling Pathway Circadian Regulation Of Gene Expression Cellular Response To Sterol T-helper Cell Differentiation Positive Regulation Of Circadian Rhythm Regulation Of Fat Cell Differentiation Positive Regulation Of DNA-templated Transcription Rhythmic Process Lymph Node Development Peyer's Patch Development Adipose Tissue Development Negative Regulation Of Thymocyte Apoptotic Process T-helper 17 Cell Differentiation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian expression	Nuclear Receptor transcription pathway Interleukin-4 and Interleukin-13 signaling Expression of BMAL (ARNTL), CLOCK, and NPAS2 Phosphorylated BMAL1:CLOCK (ARNTL:CLOCK) activates expression of core clock genes RORA,B,C and NR1D1 (REV-ERBA) regulate gene expression
GWAS		Hip circumference adjusted for BMI ( 34021172 ) Hip index ( 34021172 ) Response to bupropion and depression ( 27622933 ) Waist-hip index ( 34021172 ) Waist-to-hip ratio adjusted for BMI ( 26426971 34021172 ) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971 ) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971 )	Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Asthma ( 30929738 31619474 ) Asthma (childhood onset) ( 30929738 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 28067908 ) Depressive symptoms (SSRI exposure interaction) ( 25649181 ) Inflammatory bowel disease ( 23128233 28067908 ) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514 ) Ulcerative colitis ( 28067908 )
Interacting Genes		22 interacting genes: BHLHE40 CLOCK CRY1 CRY2 CSNK1E CSNK2A1 CSNK2A2 CSNK2B DELEC1 FBXW11 GSK3B MYOD1 NONO PER2 PPP2CB PPP2R1B PPP2R5E RASD1 RORA RORC SIRT1 WDR5	24 interacting genes: BHLHE41 BMAL2 CHD4 CIPC CLOCK CSNK1E DELEC1 EIF4EBP1 EVI2A FBXL15 NCOA6 NPAS2 NR1D2 PER2 PPP1CA PPP1CB PPP1CC PPP2CA PPP2R1A PPP2R1B PPP2R5D PPP2R5E PSMC5 RORB
Entrez ID		79365	6097
HPRD ID		16204	04250
Ensembl ID		ENSG00000123095	ENSG00000143365
Uniprot IDs		Q8TAT1 Q9C0J9	B4DPR1 F1D8P6 P51449 Q6I9R9
PDB IDs		Not available	3B0W 3KYT 3L0J 3L0L 4NB6 4NIE 4QM0 4S14 4WLB 4WPF 4WQP 4XT9 4YMQ 4YPQ 4ZJR 4ZJW 4ZOM 5APH 5APJ 5APK 5AYG 5C4O 5C4S 5C4T 5C4U 5EJV 5ETH 5G42 5G43 5G44 5G45 5G46 5IXK 5IZ0 5K38 5K3L 5K3M 5K3N 5K6E 5K74 5LWP 5M96 5NI5 5NI7 5NI8 5NIB 5NTI 5NTK 5NTN 5NTP 5NTQ 5NTW 5NU1 5UFO 5UFR 5UHI 5VB3 5VB5 5VB6 5VB7 5VQK 5VQL 5W4R 5W4V 5X8Q 5YP5 5YP6 5ZA1 6A22 6B30 6B31 6B33 6BN6 6BR2 6BR3 6CN5 6CN6 6CVH 6E3E 6E3G 6ESN 6FGQ 6FZU 6G05 6G07 6IVX 6J1L 6J3N 6LO9 6LOA 6LOB 6LOC 6NAD 6NWS 6NWT 6NWU 6O3Z 6O98 6P9F 6Q2W 6Q6M 6Q6O 6Q7A 6Q7H 6R7A 6R7J 6R7K 6SAL 6SLZ 6T4G 6T4I 6T4J 6T4K 6T4T 6T4U 6T4W 6T4X 6T4Y 6T50 6TLM 6TLQ 6TLT 6U25 6UCG 6VQF 6VSW 6W9H 6W9I 6XAE 6XFV 7E3M 7JH2 7JTM 7JTW 7JYM 7KCO 7KQJ 7KXD 7KXE 7KXF 7LUK 7NEC 7NP5 7NP6 7NPC 7OFI 7OFK 7QP4 7W3P 7W3Q 7XQE 8FAV 8FB1 8FB2 8GXP 8X7E 8XU5
GO Terms Enriched among Interactors		Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Circadian Regulation Of Gene Expression Photoperiodism Negative Regulation Of Intracellular Signal Transduction Protein Kinase CK2 Complex Positive Regulation Of Circadian Rhythm Nucleus Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Entrainment Of Circadian Clock Negative Regulation Of Cell Communication Negative Regulation Of Signaling Negative Regulation Of Metabolic Process Negative Regulation Of Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Regulation Of Ubiquitin-dependent Protein Catabolic Process Cellular Response To Stress Regulation Of Glucose Metabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Macromolecule Metabolic Process Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Primary Metabolic Process Nuclear Receptor Binding Regulation Of Proteolysis Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of Circadian Rhythm Negative Regulation Of Biosynthetic Process Gluconeogenesis Hexose Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process E-box Binding Regulation Of Metabolic Process Wnt Signaling Pathway Protein Phosphatase Type 2A Complex Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of RNA Metabolic Process Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Negative Regulation Of DNA-templated Transcription Blue Light Signaling Pathway DNA (6-4) Photolyase Activity Deoxyribodipyrimidine Photo-lyase Activity Blue Light Photoreceptor Activity	Circadian Regulation Of Gene Expression Rhythmic Process Regulation Of Circadian Rhythm Circadian Rhythm Protein Phosphatase Type 2A Complex Photoperiodism Entrainment Of Circadian Clock CLOCK-BMAL Transcription Complex Entrainment Of Circadian Clock By Photoperiod PTW/PP1 Phosphatase Complex Protein Serine/threonine Phosphatase Activity Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Protein Phosphatase Regulator Activity Meiotic Sister Chromatid Cohesion Nucleus Glycogen Metabolic Process RNA Polymerase II CTD Heptapeptide Repeat S5 Phosphatase Activity Polysaccharide Metabolic Process Energy Reserve Metabolic Process Protein Dephosphorylation Chromatin Regulation Of Gene Expression Meiotic Sister Chromatid Cohesion, Centromeric Cytosol Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sister Chromatid Cohesion Nucleoplasm Negative Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Biosynthetic Process Transcription Elongation By RNA Polymerase II Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Dephosphorylation Phosphoprotein Phosphatase Activity DNA-templated Transcription Elongation Negative Regulation Of RNA Metabolic Process E-box Binding Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Response To Light Stimulus Regulation Of DNA-templated Transcription Positive Regulation Of RNA Metabolic Process Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Chromosome, Telomeric Region Chromosome Organization Protein Dimerization Activity Negative Regulation Of Circadian Rhythm