ZNF557 and SMYD3

Number of citations of the paper that reports this interaction (PubMedID 23455924)
0

Data Source:
BioGRID (two hybrid)

		ZNF557	SMYD3
Description		zinc finger protein 557	SET and MYND domain containing 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Complex Binding RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding Protein Binding Methyltransferase Activity Zinc Ion Binding Transferase Activity Histone Methyltransferase Activity Metal Ion Binding Histone H4 Methyltransferase Activity Histone H3K36 Dimethyltransferase Activity Histone H3K4 Trimethyltransferase Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II	Chromatin Organization Nucleosome Assembly Myotube Cell Development Methylation Establishment Of Protein Localization Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Dexamethasone Stimulus
Pathways		Generic Transcription Pathway	PKMTs methylate histone lysines
Drugs
Diseases
GWAS			Bipolar disorder ( 31043756) Blood metabolite levels ( 26401656) Coffee consumption ( 31046077) DHEAS levels ( 34748635) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fractional exhaled nitric oxide (childhood) ( 24315451) Gut microbiota relative abundance (Bifidobacterium) ( 33208821) Malaria ( 31844061) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) PR interval ( 32439900) Renal underexcretion gout ( 32238385) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Systemic lupus erythematosus ( 29848360) Upper eyelid sagging severity ( 24869959)
Interacting Genes		14 interacting genes: CCDC125 CCNDBP1 CEP70 CRK GOLGA6L9 MTUS2 NSD3 PRMT6 SMAD9 SMYD3 STAT3 STX1A SUV39H1 SUV39H2	25 interacting genes: APP CAMK2B CFTR CSTF2T CYP39A1 EED EZH2 H3-4 H3-5 HELZ HSP90AA1 LCOR MAP3K2 MKRN3 NDUFAB1 NFYB NUP54 PBX2 PKN1 POLR2K RNF113A SHC3 TRIT1 VANGL1 ZNF557
Entrez ID		79230	64754
HPRD ID		15840	12297
Ensembl ID		ENSG00000130544	ENSG00000185420
Uniprot IDs		Q8N988	B3KN46 Q9H7B4
PDB IDs			3MEK 3OXF 3OXG 3OXL 3PDN 3QWP 3RU0 5CCL 5CCM 5EX0 5EX3 5HI7 5HQ8 5V37 5XXD 5XXG 5XXJ 5YJO 6IJL 6O9O 6P6G 6P6K 6P7Z 6PAF 6YUH 6ZRB 7BJ1 7O2A 7O2B 7O2C 7QLB 7QNR 7QNU 8OWO
Enriched GO Terms of Interacting Partners?		Histone Methyltransferase Activity Histone H3 Methyltransferase Activity Methyltransferase Activity Methylation Histone H3K9 Trimethyltransferase Activity Histone H3K9 Methyltransferase Activity Epigenetic Programming In The Zygotic Pronuclei Chromatin Remodeling Epigenetic Programming Of Gene Expression Chromatin Organization	Nucleus Pronucleus Transcription Corepressor Binding Chromatin Silencing Complex
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