DDA1 and PKNOX2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDA1	PKNOX2
Description		DET1 and DDB1 associated 1	PBX/knotted 1 homeobox 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Nucleoplasm Cytoplasm Actin Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge
	Molecular Function	Protein Binding	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Actin Monomer Binding Protein Binding Sequence-specific DNA Binding Actin Filament Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II
Pathways		Neddylation
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525) Systemic lupus erythematosus ( 23273568)	Alcohol and nicotine co-dependence ( 22488850) Alcohol dependence ( 21703634 21956439) Alcohol dependence symptom count ( 27151647) Alzheimer's disease (survival time) ( 25649651) Breast cancer (survival) ( 25890600) Dimensional psychopathology (Social) ( 29496196) Disease progression in age-related macular degeneration ( 29346644) Formal thought disorder in schizophrenia ( 22648509) Heel bone mineral density ( 30598549) LDL cholesterol levels in HIV infection ( 33109212) Obesity-related traits ( 23251661) Photic sneeze reflex ( 27182965) Prostate cancer ( 29892016) Schizophrenia ( 22688191) Serum uric acid levels in response to allopurinol in gout ( 25676789) Sleep duration ( 25469926) Substance dependence ( 21298047) Testicular germ cell tumor ( 28604728)
Interacting Genes		6 interacting genes: AGTRAP CMTM5 CUL4B LNX2 PKNOX2 RDH10	32 interacting genes: ARFIP2 C10orf88 C1orf216 CCDC116 CCDC185 CCDC196 CENPP CREBL2 CSTF2T CTTNBP2 CTTNBP2NL DDA1 ENKD1 FAM110B FHL2 HGS HOXB1 IQGAP1 MBD3 MCRS1 MYO15B NRIP1 NUP54 NUP58 PICK1 SMARCD1 STK16 TRIB3 TSG101 USHBP1 VPS37C YAP1
Entrez ID		79016	63876
HPRD ID		15107	17857
Ensembl ID		ENSG00000130311	ENSG00000165495
Uniprot IDs		Q9BW61	B7ZAF3 Q96KN3
PDB IDs		6DSZ 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5 8G46 8QH5 8ROX 8ROY 8TL6 9BZ0 9DHD 9FD2
Enriched GO Terms of Interacting Partners?		Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process	Protein Transport To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Multivesicular Body Organization Multivesicular Body Assembly Membrane Curvature Sensor Activity Transcription Corepressor Activity Late Endosome To Vacuole Transport Protein Domain Specific Binding Endosome Transport Via Multivesicular Body Sorting Pathway Membrane Fission Multivesicular Body Sorting Pathway ESCRT I Complex Establishment Of Protein Localization To Vacuole Macroautophagy Regulation Of MAP Kinase Activity Positive Regulation Of Exosomal Secretion Intracellular Protein Transport FAR/SIN/STRIPAK Complex Endosome Organization Regulation Of Exosomal Secretion Protein Localization To Vacuole Viral Budding Via Host ESCRT Complex Structural Constituent Of Nuclear Pore Viral Budding
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