DDA1 and RDH10

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		DDA1	RDH10
Description		DET1 and DDB1 associated 1	retinol dehydrogenase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cul4-RING E3 Ubiquitin Ligase Complex	Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Lipid Droplet Membrane
	Molecular Function	Protein Binding	All-trans-retinol Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor All-trans-retinol Dehydrogenase (NADP+) Activity
	Biological Process	Protein Polyubiquitination Protein Ubiquitination Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process	Retinoid Metabolic Process Metanephros Development In Utero Embryonic Development Retinoic Acid Biosynthetic Process Lipid Metabolic Process Visual Perception Gonad Development Animal Organ Morphogenesis Regulation Of Hormone Levels Neural Crest Cell Development Embryonic Camera-type Eye Development Embryonic Forelimb Morphogenesis Retinol Metabolic Process Retinal Metabolic Process Ear Development Nose Development Embryonic Organ Development Embryonic Viscerocranium Morphogenesis Primary Lung Bud Formation Bud Elongation Involved In Lung Branching Positive Regulation Of Retinoic Acid Biosynthetic Process
Pathways		Neddylation	The canonical retinoid cycle in rods (twilight vision) RA biosynthesis pathway
Drugs
Diseases
GWAS		Mitochondrial DNA copy number ( 30704525) Systemic lupus erythematosus ( 23273568)	Anthracycline-induced cardiotoxicity in early breast cancer ( 32378780) Ceramide levels (C24:0) ( 32489964) Crohn's disease ( 22412388) Refractive error ( 32231278) Systolic blood pressure ( 30578418)
Interacting Genes		6 interacting genes: AGTRAP CMTM5 CUL4B LNX2 PKNOX2 RDH10	4 interacting genes: ACSF2 DDA1 GAD2 RMDN2
Entrez ID		79016	157506
HPRD ID		15107	07605
Ensembl ID		ENSG00000130311	ENSG00000121039
Uniprot IDs		Q9BW61	Q8IZV5
PDB IDs		6DSZ 6PAI 6Q0R 6Q0V 6Q0W 6SJ7 6UD7 6UE5 8G46 8QH5 8ROX 8ROY 8TL6 9BZ0 9DHD 9FD2
Enriched GO Terms of Interacting Partners?		Primary Lung Bud Formation Positive Regulation Of Retinoic Acid Biosynthetic Process	Gamma-aminobutyric Acid Biosynthetic Process L-glutamate Catabolic Process Gamma-aminobutyric Acid Metabolic Process Carbon-carbon Lyase Activity Succinate Metabolic Process Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Medium-chain Fatty Acid-CoA Ligase Activity Long-chain Fatty Acid-CoA Ligase Activity Dicarboxylic Acid Catabolic Process Monocarboxylic Acid Metabolic Process Carboxy-lyase Activity
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