ERI1

Description		exoribonuclease 1
Image
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Histone Pre-mRNA 3'end Processing Complex
	Molecular Function	3'-5'-RNA Exonuclease Activity Nucleic Acid Binding RNA Binding Nuclease Activity Exonuclease Activity Protein Binding 3'-5' Exonuclease Activity Hydrolase Activity RRNA Binding Ribosome Binding Metal Ion Binding Histone Pre-mRNA Stem-loop Binding
	Biological Process	Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Regulatory NcRNA-mediated Gene Silencing RRNA 3'-end Processing Histone MRNA Catabolic Process
Pathways		Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		A body shape index ( 34021172) Acne (severe) ( 24927181) Bipolar disorder (early vs late onset) ( 34016946) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Eosinophil percentage of white cells ( 32888494) Fish- and plant-related diet ( 32066663) General factor of neuroticism ( 30867560) Mean corpuscular hemoglobin ( 27863252 32888494) Mean corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Morning person ( 30696823) Neuroticism ( 29255261) Platelet distribution width ( 32888494 27863252) Processed meat consumption ( 32066663) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		3 interacting genes: OGT SLBP VHL
Entrez ID		90459
HPRD ID		11784
Ensembl ID		ENSG00000104626
Uniprot IDs		Q8IV48
PDB IDs		1W0H 1ZBH 1ZBU 4L8R 4QOZ
Enriched GO Terms of Interacting Partners?		Regulation Of TOR Signaling Regulation Of TORC1 Signaling Histone MRNA Stem-loop Binding Complex Histone Pre-mRNA Stem-loop Binding Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Histone Pre-mRNA DCP Binding Cap-dependent Translational Initiation MRNA 3'-end Processing By Stem-loop Binding And Cleavage Histone Pre-mRNA 3'end Processing Complex Positive Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Non-canonical Inflammasome Complex Assembly Positive Regulation Of Transcription By Glucose Regulation Of Transcription From RNA Polymerase II Promoter By Glucose Protein O-acetylglucosaminyltransferase Activity Carbon Catabolite Regulation Of Transcription Transcription Elongation Factor Activity Negative Regulation Of Catabolic Process Regulation Of Transcription By Glucose NSL Complex Regulation Of Cellular Response To Hypoxia Negative Regulation Of Receptor Signaling Pathway Via JAK-STAT Protein Serine/threonine Kinase Binding Negative Regulation Of Transcription Elongation By RNA Polymerase II Histone MRNA Metabolic Process Acetylglucosaminyltransferase Activity Histone Acetyltransferase Complex Sin3-type Complex Regulation Of Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane
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