KIRREL1 and NPHS2

Number of citations of the paper that reports this interaction (PubMedID 12424224)
0

Data Source:
HPRD (in vitro, in vivo)

		KIRREL1	NPHS2
Description		kirre like nephrin family adhesion molecule 1	NPHS2 stomatin family member, podocin
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Dendritic Shaft Perinuclear Region Of Cytoplasm	Endoplasmic Reticulum Plasma Membrane Cell-cell Junction Cytoplasmic Side Of Plasma Membrane Membrane Protein-containing Complex Slit Diaphragm Membrane Raft Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Myosin Binding Cell Adhesion Molecule Binding	Protein Binding
	Biological Process	Glomerular Filtration Positive Regulation Of Actin Filament Polymerization Cell-cell Junction Maintenance Renal Protein Absorption Cell-cell Adhesion	Glomerular Filtration Gene Expression Actin Cytoskeleton Organization Renal System Development Metanephric Podocyte Development
Pathways		Nephrin family interactions Nephrin family interactions	Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS
Interacting Genes		3 interacting genes: NPHS1 NPHS2 TJP1	7 interacting genes: CD2AP FOXC1 FOXC2 KIRREL1 KIRREL3 LMX1B NPHS1
Entrez ID		55243	7827
HPRD ID		06306	05303
Ensembl ID		ENSG00000183853	ENSG00000116218
Uniprot IDs		B4DN67 Q96J84	Q9NP85
PDB IDs
Enriched GO Terms of Interacting Partners?		Epithelial Cell Development Slit Diaphragm Podocyte Development Cell Periphery Protein Localization To Cell Junction Cell Adhesion Molecule Binding Cell Development Cell-cell Junction Assembly Renal System Development Cell-cell Junction Organization Filtration Diaphragm Assembly Slit Diaphragm Assembly Metanephric Podocyte Development Cell-cell Junction Regulation Of Actin Filament Organization Cell Junction Assembly Gene Expression Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Regulation Of Actin Cytoskeleton Organization Ameloblast Differentiation Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Blood-brain Barrier Permeability Actin Filament-based Process Glomerular Basement Membrane Development Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Cell-cell Adhesion Establishment Of Endothelial Intestinal Barrier Regulation Of Cytoskeleton Organization Positive Regulation Of Vascular Permeability Glomerular Filtration Protein Localization To Cell-cell Junction Cell-cell Junction Maintenance Renal Filtration Regulation Of Bicellular Tight Junction Assembly Myosin Binding Gap Junction Cellular Developmental Process Positive Regulation Of Sprouting Angiogenesis Myoblast Fusion Apical Junction Complex Maintenance Of Blood-brain Barrier Protein-containing Complex Negative Regulation Of Stress Fiber Assembly Cell-cell Fusion	Apoptotic Process Involved In Outflow Tract Morphogenesis Negative Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Regulation Of Apoptotic Process Involved In Outflow Tract Morphogenesis Cell-cell Junction Apoptotic Process Involved In Heart Morphogenesis Glomerular Epithelium Development Paraxial Mesoderm Formation Renal Protein Absorption Slit Diaphragm Cell Adhesion Molecule Binding Lymph Vessel Development Endothelium Development Podocyte Differentiation Cell Junction Organization Cell-cell Adhesion Kidney Development Embryonic Heart Tube Development Apoptotic Process Involved In Morphogenesis Cell-cell Junction Organization Myosin Binding Neural Crest Cell Development Cardiac Muscle Cell Proliferation Cell Differentiation Involved In Kidney Development Apoptotic Process Involved In Development Stem Cell Development Vascular Endothelial Growth Factor Receptor Signaling Pathway Epithelium Development Extracellular Matrix Organization Tissue Development Extracellular Structure Organization Ureteric Bud Development Dendritic Shaft Blood Vessel Remodeling Regionalization Renal Absorption Cellular Developmental Process Muscle Cell Proliferation Ventricular Cardiac Muscle Tissue Morphogenesis Mesoderm Formation Somitogenesis Mesonephric Tubule Development Mesonephric Epithelium Development Positive Regulation Of Actin Filament Polymerization Segmentation Cell Adhesion Cell Development Heart Morphogenesis Cardiac Muscle Tissue Morphogenesis Formation Of Primary Germ Layer Regulation Of Actin Cytoskeleton Organization
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