KIRREL and NPHS1

Number of citations of the paper that reports this interaction (PMID 12865409)
44

Data Source:
HPRD (in vivo, in vitro)

		KIRREL	NPHS1
Gene Name		kin of IRRE like (Drosophila)	nephrosis 1, congenital, Finnish type (nephrin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Integral Component Of Membrane Cell Projection Membrane Dendritic Shaft Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome	Plasma Membrane Integral Component Of Plasma Membrane Slit Diaphragm Cell Projection Protein Complex Membrane Raft Extracellular Vesicular Exosome
	Molecular Function	Protein Binding Myosin Binding	Protein Binding Myosin Binding Protein Domain Specific Binding Spectrin Binding Alpha-actinin Binding
	Biological Process	Negative Regulation Of Protein Phosphorylation Excretion Single Organismal Cell-cell Adhesion Positive Regulation Of Actin Filament Polymerization	Cell Adhesion JNK Cascade Skeletal Muscle Tissue Development Myoblast Fusion Excretion Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Regulation Of Excretion Glomerular Visceral Epithelial Cell Development
Pathways
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: NPHS1 NPHS2 TJP1	11 interactors: CASK CD2AP FYN IQGAP1 KIRREL LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		55243	4868
HPRD ID		06306	04094
Ensembl ID		ENSG00000183853	ENSG00000161270
Uniprot IDs		Q96J84	O60500
PDB IDs
Enriched GO Terms of Interacting Partners?		Glomerular Visceral Epithelial Cell Development Epithelial Cell Development Glomerular Visceral Epithelial Cell Differentiation Cell Differentiation Involved In Kidney Development Excretion Epithelial Cell Differentiation Glomerulus Development Epithelium Development Nephron Development Cell-cell Signaling Involved In Cell-cell Junction Organization Kidney Epithelium Development Metanephric Glomerular Visceral Epithelial Cell Development Tissue Development Response To Magnetism Cell Development Kidney Development Renal System Development Urogenital System Development Establishment Of Endothelial Intestinal Barrier Cell Differentiation Involved In Metanephros Development Negative Regulation Of Vascular Permeability Glomerular Basement Membrane Development Metanephric Glomerulus Development Myoblast Fusion Regulation Of Excretion Cell Differentiation Establishment Of Endothelial Barrier Hippo Signaling Metanephric Epithelium Development Regulation Of Vascular Permeability Syncytium Formation Blastocyst Formation Metanephric Nephron Development Anatomical Structure Formation Involved In Morphogenesis Endothelial Cell Development Myotube Differentiation Cellular Response To Glucose Stimulus Cellular Component Disassembly Involved In Execution Phase Of Apoptosis Multicellular Organismal Development Actin Cytoskeleton Reorganization Anatomical Structure Development Execution Phase Of Apoptosis Cellular Glucose Homeostasis Cellular Response To Carbohydrate Stimulus Endothelial Cell Differentiation JNK Cascade Endothelium Development Developmental Process Blastocyst Development Metanephros Development	Cellular Response To Platelet-derived Growth Factor Stimulus Response To Platelet-derived Growth Factor Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Ephrin Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Peptidyl-tyrosine Autophosphorylation Regulation Of Cell Adhesion Neuron Projection Morphogenesis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Fc-gamma Receptor Signaling Pathway Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion Axon Guidance Regulation Of Lymphocyte Activation Neuron Projection Development Cell Migration Cell Projection Morphogenesis Cell Part Morphogenesis Regulation Of Cell Activation Signal Complex Assembly Cell Motility Enzyme Linked Receptor Protein Signaling Pathway T Cell Costimulation Neuron Development Axonogenesis Phagocytosis Axon Development Fc Receptor Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Cell Morphogenesis Vascular Endothelial Growth Factor Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Chemotaxis Neuron Differentiation Cell Development Regulation Of Endoplasmic Reticulum Stress-induced EIF2 Alpha Phosphorylation Cell Morphogenesis Involved In Differentiation Locomotion Immune Response-regulating Cell Surface Receptor Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Positive Regulation Of Protein Complex Assembly Movement Of Cell Or Subcellular Component Regulation Of Cell Proliferation
Tagcloud ?		cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Difference) ?		cajal cdh cdh2 factored feline gist gists harbor hardy hif1a homeobox iccs igf1r igf2 insr kin lhx lhx2 lim molecularly neurofilament pdgfra sdh subpopulations succinate underscore zuckerman	1beta actin actinin actn4 blocks coactivator cytosol defective fails filtration focal fsgs glomerular glomerulosclerosis ikappabalpha k255e mechanistically p50 p65 podocytes potentiate proteinuria recruit reporter segmental specialized terminally tnfalpha translocate
Tagcloud (Intersection) ?