KIRREL1 and NPHS1

Number of citations of the paper that reports this interaction (PubMedID 12865409)
37

Data Source:
HPRD (in vitro, in vivo)

		KIRREL1	NPHS1
Description		kirre like nephrin family adhesion molecule 1	NPHS1 adhesion molecule, nephrin
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Membrane Dendritic Shaft Perinuclear Region Of Cytoplasm	Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Slit Diaphragm Cell Projection Extracellular Exosome Cell Periphery
	Molecular Function	Protein Binding Myosin Binding Cell Adhesion Molecule Binding	Protein Binding Myosin Binding Cell Adhesion Molecule Binding
	Biological Process	Glomerular Filtration Positive Regulation Of Actin Filament Polymerization Cell-cell Junction Maintenance Renal Protein Absorption Cell-cell Adhesion	MAPK Cascade Cell Adhesion JNK Cascade Muscle Organ Development Skeletal Muscle Tissue Development Myoblast Fusion Gene Expression Positive Regulation Of Actin Filament Polymerization Glomerular Basement Membrane Development Protein Localization To Synapse Slit Diaphragm Assembly Podocyte Development Cell-cell Adhesion
Pathways		Nephrin family interactions Nephrin family interactions	Nephrin family interactions Nephrin family interactions
Drugs
Diseases			Nephrotic syndrome and focal segmental glomerulosclerosis
GWAS
Interacting Genes		3 interacting genes: NPHS1 NPHS2 TJP1	11 interacting genes: CASK CD2AP FYN IQGAP1 KIRREL1 LYN NCK1 NCK2 NPHS2 SRC YES1
Entrez ID		55243	4868
HPRD ID		06306	04094
Ensembl ID		ENSG00000183853	ENSG00000161270
Uniprot IDs		B4DN67 Q96J84	O60500
PDB IDs			4ZRT
Enriched GO Terms of Interacting Partners?		Epithelial Cell Development Slit Diaphragm Podocyte Development Cell Periphery Protein Localization To Cell Junction Cell Adhesion Molecule Binding Cell Development Cell-cell Junction Assembly Renal System Development Cell-cell Junction Organization Filtration Diaphragm Assembly Slit Diaphragm Assembly Metanephric Podocyte Development Cell-cell Junction Regulation Of Actin Filament Organization Cell Junction Assembly Gene Expression Positive Regulation Of Blood-brain Barrier Permeability Protein Localization To Adherens Junction Protein Localization To Bicellular Tight Junction Adherens Junction Maintenance Regulation Of Actin Cytoskeleton Organization Ameloblast Differentiation Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Regulation Of Blood-brain Barrier Permeability Actin Filament-based Process Glomerular Basement Membrane Development Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin Cell Junction Organization Cell-cell Adhesion Establishment Of Endothelial Intestinal Barrier Regulation Of Cytoskeleton Organization Positive Regulation Of Vascular Permeability Glomerular Filtration Protein Localization To Cell-cell Junction Cell-cell Junction Maintenance Renal Filtration Regulation Of Bicellular Tight Junction Assembly Myosin Binding Gap Junction Cellular Developmental Process Positive Regulation Of Sprouting Angiogenesis Myoblast Fusion Apical Junction Complex Maintenance Of Blood-brain Barrier Protein-containing Complex Negative Regulation Of Stress Fiber Assembly Cell-cell Fusion	Ephrin Receptor Signaling Pathway Cell-cell Junction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus Enzyme-linked Receptor Protein Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc Receptor Mediated Stimulatory Signaling Pathway Response To Platelet-derived Growth Factor Actin Filament Ephrin Receptor Binding Negative Regulation Of Inflammatory Response To Antigenic Stimulus Immune Response-activating Cell Surface Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Positive Regulation Of T Cell Activation Cell Migration Positive Regulation Of Leukocyte Cell-cell Adhesion Immune Response-regulating Cell Surface Receptor Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Signal Complex Assembly Slit Diaphragm T Cell Costimulation Positive Regulation Of Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Cell Motility Immune Response-activating Signaling Pathway Fc Receptor Signaling Pathway Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Signaling Receptor Binding Immune Response-regulating Signaling Pathway Scaffold Protein Binding Activation Of Immune Response Response To Transforming Growth Factor Beta Regulation Of Cell Adhesion Stimulatory C-type Lectin Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Cellular Response To Lectin Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Cell Periphery Actin Filament Organization Positive Regulation Of Immune System Process Response To Growth Factor Protein Tyrosine Kinase Activity Regulation Of Cell Activation Transmembrane Transporter Binding Positive Regulation Of Immune Response Antigen Receptor-mediated Signaling Pathway Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?