CSDE1 and CDC7

		CSDE1	CDC7
Description		cold shock domain containing E1	cell division cycle 7
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GO Annotations	Cellular Component	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex	Nucleus Nucleoplasm Cytoplasm Intercellular Bridge Mitotic Spindle
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Via Break-induced Replication Signal Transduction Positive Regulation Of Cell Population Proliferation Positive Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Cell Cycle Phase Transition Cell Division
Pathways			Activation of ATR in response to replication stress Activation of the pre-replicative complex Transcriptional Regulation by E2F6
Drugs
Diseases
GWAS		Autism ( 24189344)	Eosinophil percentage of white cells ( 27863252) Gestational age at birth (maternal effect) ( 28877031) Glaucoma (primary open-angle) ( 33627673 25861811) Lung function (FEV1/FVC) ( 28166213) Lung function (FVC) ( 26635082) Optic disc area ( 21307088 31798171 28073927 25631615) Optic disc parameters ( 20548946) Optic disc size ( 31809533) Optic nerve measurement (cup-to-disc ratio) ( 28061514) Plateletcrit ( 32888494) PR interval ( 32439900) Response to fenofibrate (HDL cholesterol levels) ( 27002377) Vertical cup-disc ratio ( 28073927 25241763 31798171) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		18 interacting genes: ARHGAP5 C11orf68 CEBPA ERBB2 FAM9B FOXP1 HID1 HNRNPD NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SNW1 STT3A SYNCRIP WBP4 WNK1	52 interacting genes: APP BANP CALCOCO2 CDK2 CDK4 CDK9 CDKN1A CDKN2A CHAF1A CLSPN DBF4 DBF4B DIAPH1 DTD1 FXR1 GMEB2 GOLGA2 GOLGA6A GPT GRHPR HMBOX1 HOMEZ IKZF1 IKZF3 IKZF4 LZTS1 MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MEOX2 MTUS2 NDUFB2 ORC1 ORC5 ORC6 PGK1 SERTAD2 STAM2 TMBIM6 TOB1 TRIM27 TRIM37 TSNAXIP1 TSPY10 TSPY3 ZBTB10 ZBTB26 ZBTB8B
Entrez ID		7812	8317
HPRD ID		15949	10345
Ensembl ID		ENSG00000009307	ENSG00000097046
Uniprot IDs		O75534	A0A384MTU6 B2R6V2 O00311
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY	4F99 4F9A 4F9B 4F9C 5UWQ 5UWR 6YA6 6YA7 6YA8
Enriched GO Terms of Interacting Partners?		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding	DNA Replication Initiation DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of DNA Replication CMG Complex MCM Complex Double-strand Break Repair Via Break-induced Replication Chromosome, Telomeric Region DNA Metabolic Process DNA Binding Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus DNA Replication Origin Binding Single-stranded DNA Helicase Activity Nuclear Origin Of Replication Recognition Complex Regulation Of Primary Metabolic Process Regulation Of DNA Metabolic Process Nucleoplasm Single-stranded DNA Binding Mitotic DNA Replication Initiation Regulation Of Metabolic Process Origin Recognition Complex Regulation Of G2/M Transition Of Mitotic Cell Cycle Nucleic Acid Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Helicase Activity DNA Repair Double-strand Break Repair Via Homologous Recombination DNA Damage Response Recombinational Repair DNA Helicase Activity Positive Regulation Of DNA Replication Dbf4-dependent Protein Kinase Complex DNA Strand Elongation Involved In DNA Replication Positive Regulation Of DNA-templated DNA Replication Negative Regulation Of RNA Metabolic Process Chromatin Regulation Of Mitotic Cell Cycle DNA Strand Elongation Mesoderm Development Chromatin Organization Cellular Response To Stress Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Mitotic DNA Integrity Checkpoint Signaling Regulation Of Mitotic Cell Cycle Phase Transition Cyclin-dependent Protein Serine/threonine Kinase Activity
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