CSDE1 and SNRPB2

		CSDE1	SNRPB2
Description		cold shock domain containing E1	small nuclear ribonucleoprotein polypeptide B2
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GO Annotations	Cellular Component	P-body Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cytoplasmic Stress Granule CRD-mediated MRNA Stability Complex MCRD-mediated MRNA Stability Complex	Fibrillar Center Nucleus Nucleoplasm Spliceosomal Complex U2-type Spliceosomal Complex U1 SnRNP U2 SnRNP Nuclear Speck Cytoplasmic Ribonucleoprotein Granule U2-type Precatalytic Spliceosome U2-type Catalytic Step 2 Spliceosome Catalytic Step 2 Spliceosome Spliceosomal SnRNP Complex Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding RNA Binding MRNA Binding Protein Binding RNA Stem-loop Binding LncRNA Binding RISC Complex Binding	Nucleic Acid Binding RNA Binding Protein Binding U1 SnRNA Binding
	Biological Process	Regulation Of Translational Initiation Male Gonad Development Stress Granule Assembly Positive Regulation Of Translation ERK1 And ERK2 Cascade CRD-mediated MRNA Stabilization Nuclear-transcribed MRNA Catabolic Process, No-go Decay IRES-dependent Viral Translational Initiation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation	MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing U2-type Prespliceosome Assembly
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Autism ( 24189344)	Food allergy (maternal genetic effects) ( 29489655) Metabolite levels ( 23823483) Response to haloperidol in schizophrenia ( 29503163)
Interacting Genes		18 interacting genes: ARHGAP5 C11orf68 CEBPA ERBB2 FAM9B FOXP1 HID1 HNRNPD NEIL3 PABPC1 PCSK7 PSMG1 RNF10 SNW1 STT3A SYNCRIP WBP4 WNK1	26 interacting genes: ALAS1 CALM1 CEBPA CMTM6 DHX9 ERBB3 FOXP1 GABPB1 GABPB2 GOLGA2 HMBOX1 HNRNPUL1 HOMEZ HTATSF1 MCM6 MTUS2 NAP1L5 PICK1 PNMA1 PTEN SMN2 SNRPA1 SUGP1 TRIM23 TRIM27 ZBTB14
Entrez ID		7812	6629
HPRD ID		15949	04628
Ensembl ID		ENSG00000009307	ENSG00000125870
Uniprot IDs		O75534	P08579
PDB IDs		1WFQ 1X65 2YTV 2YTX 2YTY	1A9N 5MQF 5O9Z 5XJC 5YZG 5Z56 5Z57 5Z58 6AH0 6AHD 6FF7 6ICZ 6ID0 6ID1 6QDV 6QX9 6Y53 6Y5Q 7A5P 7ABG 7ABI 7EVO 7VPX 7W59 7W5A 7W5B 8C6J 8CH6 8H6E 8H6J 8H6K 8H6L 8HK1 8I0P 8I0R 8I0S 8I0T 8I0U 8I0V 8I0W 8QO9 8QXD 8QZS 8R08 8R09 8R0A 8R0B 8RM5 9FMD
Enriched GO Terms of Interacting Partners?		MCRD-mediated MRNA Stability Complex CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Positive Regulation Of Cytoplasmic Translation Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Spliceosomal Complex Catalytic Step 2 Spliceosome Macromolecule Metabolic Process MRNA Splicing, Via Spliceosome Regulation Of Cytoplasmic Translation RNA Splicing, Via Transesterification Reactions Regulation Of Translation Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Positive Regulation Of Translation MRNA Stabilization Regulation Of Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Carbohydrate Homeostasis Glucose Homeostasis Negative Regulation Of MRNA Catabolic Process RNA Stabilization Nucleic Acid Binding RNA Splicing Proteasome Binding Response To Ketone Post-transcriptional Regulation Of Gene Expression Negative Regulation Of RNA Catabolic Process Negative Regulation Of MRNA Metabolic Process Motor Neuron Axon Guidance Nuclear Androgen Receptor Binding MRNA Processing Regulation Of Protein Metabolic Process Regulation Of Biological Quality Nuclear Matrix Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Uracil Binding Beta-alanine Metabolic Process Thymidine Catabolic Process Beta-alanine Biosynthetic Process Dihydropyrimidine Dehydrogenase (NADP+) Activity Hepatocyte Dedifferentiation Cellular Response To Putrescine Negative Regulation Of Smooth Muscle Cell Migration Negative Regulation Of Skeletal Muscle Hypertrophy U2-type Catalytic Step 2 Spliceosome Proteasome Core Complex Assembly Induction Of Negative Chemotaxis Corticospinal Neuron Axon Guidance Through Spinal Cord Protein Localization To Vacuolar Membrane MCM Complex Binding	Identical Protein Binding Nucleoplasm Nucleus RNA Splicing RNA Splicing, Via Transesterification Reactions Single-stranded 3'-5' DNA Helicase Activity RISC Complex Binding MRNA Metabolic Process CRD-mediated MRNA Stability Complex MRNA Processing Spliceosomal Complex Assembly Importin-alpha Family Protein Binding CRD-mediated MRNA Stabilization Negative Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay RNA Stem-loop Binding Cytoplasmic Ribonucleoprotein Granule Protein-RNA Complex Assembly MRNA Splicing, Via Spliceosome Meiotic Spindle Assembly Positive Regulation Of Cytoplasmic Translation DNA-templated Transcription Termination Regulation Of Viral Transcription Regulation Of Nuclear-transcribed MRNA Catabolic Process, Deadenylation-dependent Decay Meiotic Spindle Organization Macromolecule Metabolic Process Transcription Cis-regulatory Region Binding Nucleic Acid Metabolic Process Alternative MRNA Splicing, Via Spliceosome PML Body U2-type Prespliceosome Assembly U2 SnRNP U2-type Spliceosomal Complex RNA Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Dendritic Spine Organization Response To Stress Protein Binding Positive Regulation Of Biosynthetic Process RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding 3'-5' DNA/RNA Helicase Activity Regulation Of Cytoplasmic Translation DNA-templated Viral Transcription Regulatory Region RNA Binding Negative Regulation Of Synaptic Vesicle Clustering Negative Regulation Of Organ Growth Regulation Of Actin Nucleation Telomere-telomerase Complex Assembly DNA Helicase Activity RNA Processing Nucleic Acid Binding
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