CACNA1E and HSPA1A

Number of citations of the paper that reports this interaction (PMID 16543726)
3

Data Source:
HPRD (in vivo)

		CACNA1E	HSPA1A
Gene Name		calcium channel, voltage-dependent, R type, alpha 1E subunit	heat shock 70kDa protein 1A
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Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Mitochondrion Endoplasmic Reticulum Centriole Cytosol Focal Adhesion COP9 Signalosome Inclusion Body Aggresome Nuclear Speck Ribonucleoprotein Complex Vesicle Perinuclear Region Of Cytoplasm Extracellular Vesicular Exosome Blood Microparticle
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding High Voltage-gated Calcium Channel Activity	Virus Receptor Activity G-protein Coupled Receptor Binding Double-stranded RNA Binding Protein Binding ATP Binding ATPase Activity Enzyme Binding Heat Shock Protein Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Protein Binding Involved In Protein Folding Poly(A) RNA Binding Protein N-terminus Binding Unfolded Protein Binding
	Biological Process	Energy Reserve Metabolic Process Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	MRNA Catabolic Process Response To Unfolded Protein Negative Regulation Of Cell Proliferation Response To Virus Gene Expression Regulation Of Cell Death Negative Regulation Of Cell Growth Negative Regulation Of Protein Ubiquitination Cellular Response To Oxidative Stress Cellular Response To Heat Protein Refolding Negative Regulation Of Apoptotic Process Positive Regulation Of Erythrocyte Differentiation Protein Stabilization Negative Regulation Of Cell Death Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Cellular Response To Heat Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Pathways		Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses	Regulation of mRNA stability by proteins that bind AU-rich elements Viral RNP Complexes in the Host Cell Nucleus Attenuation phase Regulation of HSF1-mediated heat shock response Cellular response to heat stress AUF1 (hnRNP D0) destabilizes mRNA Influenza Infection Influenza Life Cycle HSF1-dependent transactivation Export of Viral Ribonucleoproteins from Nucleus
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: EFHC1 HSPA1A	79 interactors: AIFM1 APAF1 APEX1 APOB ATXN1 BAG1 BAG2 BAG3 BAG4 BCL2 BRSK1 CACNA1E CDK9 CFAP52 DAPP1 DNAJA2 DNAJA3 DNAJB1 DNAJB11 DNAJC3 DNAJC7 DYX1C1 EGFR EIF2AK2 FANCC FOS GPR37 GRIN1 GRIN2D HCFC1 HIVEP1 HMGA1 HSBP1 HSF1 HSP90AA1 HSPA8 HSPBP1 IKBKG KRT18 KRT7 MAP3K5 MAPRE1 METTL21A MOS MSR1 NQO1 NR3C1 PEX5 PLG POT1 PPP1R15A PRKCA PTGES3 PTMA RAP1A RAPGEF2 RHOA SAE1 SLC5A1 SNCA SNCB SNRK SOX9 ST13 STIP1 STUB1 TCERG1 TGM2 TOMM70A TP53 TRIAP1 TRIM24 TRIM38 TSSK6 TTC1 YWHAB YWHAG YWHAQ YWHAZ
Entrez ID		777	3303
HPRD ID		03006	00774
Ensembl ID		ENSG00000198216	ENSG00000204389
Uniprot IDs		Q15878 Q59FG1	A8K5I0 B3KTT5 P08107
PDB IDs		3BXL	1HJO 1S3X 1XQS 2E88 2E8A 2LMG 3A8Y 3ATU 3ATV 3AY9 3D2E 3D2F 3JXU 3LOF 4J8F
Enriched GO Terms of Interacting Partners?		Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Inclusion Body Assembly Protein Refolding Positive Regulation Of Erythrocyte Differentiation Regulation Of Cellular Response To Heat Locomotion Regulation Of Erythrocyte Differentiation Viral Entry Into Host Cell Entry Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Heat Positive Regulation Of Myeloid Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cerebral Cortex Cell Migration Protein Stabilization Telencephalon Cell Migration Negative Regulation Of Protein Ubiquitination Interaction With Host Forebrain Cell Migration Response To Heat	Protein Refolding Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Death Regulation Of Apoptotic Process Positive Regulation Of Metabolic Process Protein Folding Chaperone Cofactor-dependent Protein Refolding Response To Organic Substance Cellular Response To Stimulus Response To Stress Signaling Positive Regulation Of Cellular Protein Metabolic Process Cellular Metabolic Process Negative Regulation Of Cellular Metabolic Process Cellular Response To Stress Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Modification Process Cell Communication Positive Regulation Of Cell Death Response To Stimulus Positive Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Protein Metabolic Process Regulation Of Phosphorylation Regulation Of Signaling Regulation Of Catalytic Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Regulation Of Protein Phosphorylation Regulation Of Metabolic Process Regulation Of Cellular Process Regulation Of Signal Transduction Regulation Of Cellular Component Organization Response To Abiotic Stimulus Positive Regulation Of Phosphorylation Negative Regulation Of Cell Death Positive Regulation Of Signal Transduction Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Intrinsic Apoptotic Signaling Pathway Cellular Protein Metabolic Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Intracellular Signal Transduction Regulation Of Cellular Response To Heat Regulation Of Phosphorus Metabolic Process Negative Regulation Of Biosynthetic Process Apoptotic Signaling Pathway Apoptotic Process
Tagcloud ?		abcb1 akap9 c1orf16 cpsf4 cyp51a1 est ests ets1 fnbp2 glul gnai1 gusb imprh inra inraschp mapkapk2 pepp3 positional ptgs2 qtl rab7l1 robo4 sgce siat4c ssc3 ssc9 steap thg zoo	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
Tagcloud (Difference) ?		abcb1 akap9 c1orf16 cpsf4 cyp51a1 est ests ets1 fnbp2 glul gnai1 gusb imprh inra inraschp mapkapk2 pepp3 positional ptgs2 qtl rab7l1 robo4 sgce siat4c ssc3 ssc9 steap thg zoo	chaperone complement defective dnaja1 dnajb1 enlarged experimentally heat hspa6 hsps initiated interpreted keratinocytes knockin nfkappab nodes participation peroxisome physiologic ppar proliferator represses repression shock spleen stressed tnfalpha tnip1
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