CACNA1E

Description		calcium voltage-gated channel subunit alpha1 E
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GO Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex Membrane Monoatomic Ion Channel Complex Neuronal Cell Body Synapse
	Molecular Function	Monoatomic Ion Channel Activity Voltage-gated Calcium Channel Activity Calcium Channel Activity Calcium Ion Binding High Voltage-gated Calcium Channel Activity Voltage-gated Monoatomic Cation Channel Activity Metal Ion Binding
	Biological Process	Monoatomic Ion Transport Calcium Ion Transport Chemical Synaptic Transmission Monoatomic Ion Transmembrane Transport Transmembrane Transport Calcium Ion Transmembrane Transport Calcium Ion Import Across Plasma Membrane
Pathways		Presynaptic depolarization and calcium channel opening Regulation of insulin secretion
Drugs		Ergocalciferol Enflurane Topiramate Spironolactone Lamotrigine Nicardipine Verapamil Efonidipine Butamben Bioallethrin
Diseases
GWAS		Body mass index (change over time) ( 25378290) Coronary artery calcification ( 23870195) Feeling hurt ( 29500382) Glucagon levels in response to oral glucose tolerance test (decremental area under the curve for 0-30 minutes) ( 33407418) Height ( 31562340) Intelligence (MTAG) ( 29326435) Lumbar spine bone mineral density (integral) ( 27476799) Neuroticism ( 29255261) Presence of antiphospholipid antibodies ( 27098658) Systemic mastocytosis ( 32752121)
Interacting Genes		2 interacting genes: EFHC1 HSPA1A
Entrez ID		777
HPRD ID		03006
Ensembl ID		ENSG00000198216
Uniprot IDs		Q15878 Q59FG1
PDB IDs		3BXL 7XLQ 7YG5 8EPL 8EPM
Enriched GO Terms of Interacting Partners?		Denatured Protein Binding C3HC4-type RING Finger Domain Binding Death Receptor Agonist Activity ATP-dependent Protein Disaggregase Activity Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Heat Acclimation Cellular Response To Unfolded Protein Negative Regulation Of Inclusion Body Assembly Positive Regulation Of Erythrocyte Differentiation Aggresome Centrosome Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Inclusion Body Assembly Disordered Domain Specific Binding Negative Regulation Of Mitochondrial Membrane Permeability Inclusion Body Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Mitotic Spindle Assembly Negative Regulation Of Membrane Permeability Protein Refolding ATP-dependent Protein Folding Chaperone COP9 Signalosome Negative Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Cellular Response To Topologically Incorrect Protein Misfolded Protein Binding Chaperone-mediated Protein Complex Assembly Regulation Of Microtubule Nucleation Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Microtubule Nucleation Positive Regulation Of Microtubule Polymerization Regulation Of Spindle Assembly Axonemal Microtubule Cerebral Cortex Cell Migration Axonemal A Tubule Inner Sheath Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Mitotic Spindle Organization Positive Regulation Of RNA Splicing Transcription Regulator Inhibitor Activity Alpha-tubulin Binding Telencephalon Cell Migration Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Forebrain Cell Migration Regulation Of Erythrocyte Differentiation Negative Regulation Of Response To Endoplasmic Reticulum Stress Cellular Response To Heat Positive Regulation Of Pattern Recognition Receptor Signaling Pathway Regulation Of Membrane Permeability Cytoskeleton
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