CACNA1E and EFHC1

Number of citations of the paper that reports this interaction (PMID 15258581)
32

Data Source:
HPRD (in vivo, in vitro)

		CACNA1E	EFHC1
Gene Name		calcium channel, voltage-dependent, R type, alpha 1E subunit	EF-hand domain (C-terminal) containing 1
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Voltage-gated Calcium Channel Complex	Centrosome Axoneme Neuronal Cell Body Mitotic Spindle
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Ion Binding High Voltage-gated Calcium Channel Activity	Calcium Ion Binding Protein C-terminus Binding
	Biological Process	Energy Reserve Metabolic Process Transport Synaptic Transmission Regulation Of Ion Transmembrane Transport Small Molecule Metabolic Process Regulation Of Insulin Secretion Membrane Depolarization Calcium Ion Import Calcium Ion Transmembrane Transport Membrane Depolarization During Action Potential	Cerebral Cortex Cell Migration
Pathways		Integration of energy metabolism Regulation of insulin secretion Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels Transmission across Chemical Synapses
Drugs
Diseases
GWAS
Protein-Protein Interactions		2 interactors: EFHC1 HSPA1A	6 interactors: CACNA1E EIF4ENIF1 IKZF3 REL TCF4 TEX11
Entrez ID		777	114327
HPRD ID		03006	10583
Ensembl ID		ENSG00000198216	ENSG00000096093
Uniprot IDs		Q15878 Q59FG1	B2CKC5 Q5JVL4
PDB IDs		3BXL
Enriched GO Terms of Interacting Partners?		Cellular Heat Acclimation Negative Regulation Of Inclusion Body Assembly Regulation Of Inclusion Body Assembly Protein Refolding Positive Regulation Of Erythrocyte Differentiation Regulation Of Cellular Response To Heat Locomotion Regulation Of Erythrocyte Differentiation Viral Entry Into Host Cell Entry Into Host Cell Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cellular Response To Heat Positive Regulation Of Myeloid Cell Differentiation Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cerebral Cortex Cell Migration Protein Stabilization Telencephalon Cell Migration Negative Regulation Of Protein Ubiquitination Interaction With Host Forebrain Cell Migration Response To Heat	Regulation Of Cell Death Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Epithelial To Mesenchymal Transition Catenin Import Into Nucleus Energy Reserve Metabolic Process Positive Regulation Of Heparan Sulfate Proteoglycan Biosynthetic Process Meiotic Gene Conversion Maintenance Of DNA Repeat Elements Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Negative Regulation Of Cell Death Male Meiosis Chromosome Segregation Embryonic Hindgut Morphogenesis Negative Regulation Of Type B Pancreatic Cell Apoptotic Process Embryonic Genitalia Morphogenesis Regulation Of Hormone Secretion Myoblast Fate Commitment Chiasma Assembly Sex Differentiation Secretory Granule Localization Energy Derivation By Oxidation Of Organic Compounds Hindgut Morphogenesis Insulin Metabolic Process Positive Regulation Of Interleukin-12 Biosynthetic Process Hindgut Development Resolution Of Meiotic Recombination Intermediates Positive Regulation Of Protein Export From Nucleus Positive Regulation Of Glycoprotein Biosynthetic Process Positive Regulation Of Triglyceride Biosynthetic Process Regulation Of Protein Secretion Regulation Of Apoptotic Process Positive Regulation Of Glycoprotein Metabolic Process Regulation Of Interleukin-12 Biosynthetic Process Generation Of Precursor Metabolites And Energy Positive Regulation Of Gluconeogenesis Regulation Of Triglyceride Biosynthetic Process Genitalia Morphogenesis Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Chromosome Separation Synaptonemal Complex Assembly Reproductive Structure Development Synaptonemal Complex Organization Reproductive System Development
Tagcloud ?		abcb1 akap9 c1orf16 cpsf4 cyp51a1 est ests ets1 fnbp2 glul gnai1 gusb imprh inra inraschp mapkapk2 pepp3 positional ptgs2 qtl rab7l1 robo4 sgce siat4c ssc3 ssc9 steap thg zoo	adp adpr cation cationic channel coexpressed coexpression conferred currents demonstrates disruptive epilepsy hek293 jme juvenile m2 mediating myoclonic nad permeable peroxide potentiates redox ribose susceptibility trpm2 underlie ventricle
Tagcloud (Difference) ?		abcb1 akap9 c1orf16 cpsf4 cyp51a1 est ests ets1 fnbp2 glul gnai1 gusb imprh inra inraschp mapkapk2 pepp3 positional ptgs2 qtl rab7l1 robo4 sgce siat4c ssc3 ssc9 steap thg zoo	adp adpr cation cationic channel coexpressed coexpression conferred currents demonstrates disruptive epilepsy hek293 jme juvenile m2 mediating myoclonic nad permeable peroxide potentiates redox ribose susceptibility trpm2 underlie ventricle
Tagcloud (Intersection) ?