EFHC1 and TRPM2

Number of citations of the paper that reports this interaction (PubMedID 22226147)
0

Data Source:
BioGRID (pull down)

		EFHC1	TRPM2
Description		EF-hand domain containing 1	transient receptor potential cation channel subfamily M member 2
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GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Neuronal Cell Body Mitotic Spindle Axonemal A Tubule Inner Sheath	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Alpha-tubulin Binding	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Intracellularly Gated Calcium Channel Activity Hydrolase Activity Metal Ion Binding Metal Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Flagellated Sperm Motility Regulation Of Cell Division Cilium-dependent Cell Motility	Temperature Homeostasis Dendritic Cell Chemotaxis Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Manganese Ion Transport Response To Heat Response To Purine-containing Compound Calcium-mediated Signaling Regulation Of Actin Cytoskeleton Organization Response To Hydroperoxide Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane
Pathways			TRP channels Neutrophil degranulation
Drugs
Diseases		Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)	Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		68 interacting genes: AKT1 CACNA1E CALCOCO2 CFAP161 CHCHD3 CIMIP1 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCNJ5-AS1 KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1	3 interacting genes: EFHC1 ITPR3 TRPC6
Entrez ID		114327	7226
HPRD ID		10583	04777
Ensembl ID		ENSG00000096093	ENSG00000142185
Uniprot IDs		B2CKC5 Q5JVL4	B4DVI8 E9PGK7 O94759 Q14DR2
PDB IDs		7UNG 8J07	6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU 7VQ1 7VQ2 8E6Q 8E6R 8E6S 8E6T 8E6U 8E6V
Enriched GO Terms of Interacting Partners?		Protein Binding	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Inositol 1,3,4,5 Tetrakisphosphate Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Umami Taste Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Sensory Perception Of Sweet Taste Monoatomic Ion Channel Activity Calcium Ion Homeostasis Sensory Perception Of Bitter Taste Calcium Ion Transport Calcium Ion Transmembrane Transport Inositol Hexakisphosphate Binding Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Slit Diaphragm Store-operated Calcium Channel Activity Neuronal Cell Body TRAPPII Protein Complex Inorganic Ion Homeostasis TRAPP Complex Actinin Binding Cytoplasmic Side Of Endoplasmic Reticulum Membrane Early Endosome To Golgi Transport Cation Channel Complex Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Axonemal A Tubule Inner Sheath Sensory Perception Of Taste Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Nuclear Outer Membrane Calcium Ion Binding Intra-Golgi Vesicle-mediated Transport Vesicle Tethering Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Axonemal Microtubule Cerebral Cortex Cell Migration Vesicle Coating
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