EFHC1 and CFAP161

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		EFHC1	CFAP161
Description		EF-hand domain containing 1	cilia and flagella associated protein 161
Image
GO Annotations	Cellular Component	Spindle Pole Cytoplasm Centrosome Spindle Cytoskeleton Axonemal Microtubule Cilium Axoneme Motile Cilium Sperm Flagellum Cell Projection Neuronal Cell Body Mitotic Spindle Axonemal A Tubule Inner Sheath	Cytoplasm Cytoskeleton Axonemal Microtubule Cilium Motile Cilium Sperm Flagellum Cell Projection Axonemal A Tubule Inner Sheath
	Molecular Function	Calcium Ion Binding Protein Binding Alpha-tubulin Binding	Protein Binding
	Biological Process	Mitotic Cytokinesis Mitotic Spindle Organization Cerebral Cortex Cell Migration Flagellated Sperm Motility Regulation Of Cell Division Cilium-dependent Cell Motility	Flagellated Sperm Motility Cilium Assembly
Pathways
Drugs
Diseases		Idiopathic generalied epilepsies (IGEs), including: Childhood absence epilepsy (CAE); Juvenile absence epilepsy (JAE); Juvenile myoclonic epilepsy (JME); Epilepsy with generalized tonic-clonic seizures alone
GWAS		Atopic march ( 26542096) Clozapine-induced myocarditis in schizophrenia ( 32066683) Mean platelet volume ( 27863252) Perceived intensity of glucose ( 31005972) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) White blood cell count ( 32888494)	Coronary artery disease ( 33020668) Myocardial infarction ( 33532862)
Interacting Genes		68 interacting genes: AKT1 CACNA1E CALCOCO2 CFAP161 CHCHD3 CIMIP1 DOK7 EFHC2 EIF4ENIF1 FMR1 GADD45B GAS2L2 GOLGA2 HOMER3 IHO1 IKZF3 IMP3 ITGB3BP KCNJ5-AS1 KCTD4 KRT15 KRT18 KRT75 LMO2 LRRC61 MAMDC2 MBD3L1 METTL27 MIIP MRNIP MTFR1L NQO2 NRIP3 NUP54 OIP5 PAX6 PBX1 PBX2 PMF1 PRR5L RCN1 REL RIMBP3 RNF125 SAPCD1 SELENOV SH3GLB2 SLAIN1 SNAI1 SORBS3 SPATA2 SYNGAP1 TCF4 TEKT1 TEX11 TLE5 TP53BP2 TRAF2 TRIP6 TRPM2 TSGA10IP TTC23L UBAP2 VBP1 WASF1 WHRN YJU2B ZBED1	4 interacting genes: BCL6 CINP DPYSL5 EFHC1
Entrez ID		114327	161502
HPRD ID		10583	08243
Ensembl ID		ENSG00000096093	ENSG00000156206
Uniprot IDs		B2CKC5 Q5JVL4	Q6P656
PDB IDs		7UNG 8J07	7UNG 8J07
Enriched GO Terms of Interacting Partners?		Protein Binding	Negative Regulation Of Isotype Switching To IgE Isotypes Paraspeckles Negative Regulation Of T-helper 2 Cell Differentiation Plasma Cell Differentiation Negative Regulation Of B Cell Differentiation T-helper 2 Cell Differentiation Negative Regulation Of Isotype Switching Regulation Of Mitotic Cell Cycle DNA Replication Negative Regulation Of Mitotic Cell Cycle DNA Replication Type 2 Immune Response Negative Regulation Of Mast Cell Cytokine Production Negative Regulation Of Immunoglobulin Production Isotype Switching To IgE Isotypes Pyramidal Neuron Differentiation Negative Regulation Of Cell Development Negative Regulation Of DNA-templated DNA Replication Germinal Center Formation Regulation Of Memory T Cell Differentiation Regulation Of Germinal Center Formation Neuron Differentiation Negative Regulation Of Plasma Cell Differentiation Intronic Transcription Regulatory Region Sequence-specific DNA Binding Preribosome Binding Negative Regulation Of Dendrite Morphogenesis Pyrimidine Nucleobase Catabolic Process Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds Neuronal Cell Body Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Dihydropyrimidinase Activity Regulation Of Nuclear Cell Cycle DNA Replication Negative Regulation Of B Cell Apoptotic Process Negative Regulation Of Type 2 Immune Response Regulation Of B Cell Apoptotic Process Pyrimidine Nucleobase Metabolic Process Negative Regulation Of Rho Protein Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Negative Regulation Of DNA Replication Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Negative Regulation Of T-helper Cell Differentiation Isotype Switching Negative Regulation Of Cellular Senescence Pyrimidine-containing Compound Catabolic Process Axonemal A Tubule Inner Sheath
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