ZFAND5 and PTTG1

Number of citations: 0 (PubMedID 37214989)
Data Source: BioGRID (pull down)

		ZFAND5	PTTG1
Name		zinc finger AN1-type containing 5	PTTG1 regulator of sister chromatid separation, securin
Structure
GO Annotations	Cellular Component	Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	DNA Binding Protein Binding Zinc Ion Binding Metal Ion Binding	Cysteine-type Endopeptidase Inhibitor Activity Protein Binding SH3 Domain Binding Molecular Function Activator Activity
	Biological Process	In Utero Embryonic Development Vasculature Development Respiratory System Process Fibroblast Migration Platelet-derived Growth Factor Receptor Signaling Pathway Skeletal System Morphogenesis Smooth Muscle Tissue Development Face Development	DNA Repair DNA Damage Response Chromosome Segregation Spermatogenesis Homologous Chromosome Segregation Chromosome Organization Cell Division
Pathways		None	APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Separation of Sister Chromatids
GWAS		Sensorimotor dexterity ( 31596458 )	Dermatomyositis or juvenile dermatomyositis ( 26362759 ) Insulin-related traits ( 22791750 ) Sjögren's syndrome ( 24097067 ) Systemic lupus erythematosus ( 19838195 21408207 28714469 ) Systemic lupus erythematosus or rheumatoid arthritis ( 27193031 )
Interacting Genes		14 interacting genes: APP CCNB1 IKBKG LRRK2 MAP3K1 MFHAS1 PSMD6 PTTG1 RAD23B RIPK1 SMURF1 TNFAIP3 TRAF6 UBC	29 interacting genes: ANAPC1 ANAPC11 ANAPC2 ANAPC4 AURKA CAMK2A CDC20 CDC27 CDC34 CDH1 CDK1 CFTR CRK CUL1 DNAJA1 FZR1 KEAP1 PLCG2 PPP2R2D PPP2R5A PRKN PTTG1IP RPS10 TP53 UBE2N UBE4A UBR5 XRCC6 ZFAND5
Entrez ID		7763	9232
HPRD ID		05302	04998
Ensembl ID		ENSG00000107372	ENSG00000164611
Uniprot IDs		O76080	O95997 Q6IAL9
PDB IDs		7QXW	7NJ0 7NJ1
GO Terms Enriched among Interactors		Positive Regulation Of Protein Metabolic Process Positive Regulation Of JNK Cascade Positive Regulation Of Defense Response Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Signal Transduction Cytosol Positive Regulation Of Immune System Process Regulation Of JNK Cascade Negative Regulation Of Signaling Negative Regulation Of Cell Communication Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Regulation Of Protein Metabolic Process Regulation Of Immune System Process Protein Metabolic Process Regulation Of Tumor Necrosis Factor Production Regulation Of Proteolysis Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Inflammatory Response Canonical NF-kappaB Signal Transduction Positive Regulation Of Proteolysis Positive Regulation Of MAPK Cascade Response To Stress Cellular Response To Manganese Ion JUN Kinase Kinase Kinase Activity Intracellular Signal Transduction Regulation Of Defense Response Intracellular Signaling Cassette Negative Regulation Of Apoptotic Signaling Pathway Signaling Adaptor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Oxygen-containing Compound Positive Regulation Of Catabolic Process Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Intracellular Signal Transduction Response To Manganese Ion Regulation Of Immune Response Negative Regulation Of Toll-like Receptor 4 Signaling Pathway Golgi-associated Vesicle Cytoplasm Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Ubiquitin Protein Ligase Binding Positive Regulation Of Tumor Necrosis Factor Production Cellular Response To Reactive Oxygen Species Cellular Response To Catecholamine Stimulus Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of DNA-binding Transcription Factor Activity Regulation Of Canonical NF-kappaB Signal Transduction	Proteasomal Protein Catabolic Process Protein Polyubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Anaphase-promoting Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Anaphase-promoting Complex-dependent Catabolic Process Protein Catabolic Process Mitotic Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Cell Cycle Phase Transition Protein Ubiquitination Protein Branched Polyubiquitination Post-translational Protein Modification Protein Modification By Small Protein Conjugation Protein Modification Process Regulation Of Meiotic Cell Cycle Macromolecule Catabolic Process Regulation Of Chromosome Segregation Proteolysis Metaphase/anaphase Transition Of Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Reproductive Process Regulation Of Cell Cycle Process Catabolic Process Cell Division Cytosol Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Protein Metabolic Process Cytoplasm Ubiquitin Protein Ligase Binding Regulation Of Cell Cycle Response To Oxidative Stress Metaphase/anaphase Transition Of Mitotic Cell Cycle Ubiquitin-protein Transferase Activity Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Organelle Organization Protein-containing Complex Ubiquitin-protein Transferase Activator Activity Regulation Of Cell Cycle Phase Transition Regulation Of Protein Ubiquitination Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Ubiquitination Regulation Of Mitotic Cell Cycle Phase Transition Positive Regulation Of Proteasomal Protein Catabolic Process Nucleus Cullin-RING Ubiquitin Ligase Complex