ZNF175 and LPXN

Number of citations: 38 (PubMedID 21988832)
Data Source: BioGRID (two hybrid)

		ZNF175	LPXN
Name		zinc finger protein 175	leupaxin
Structure		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Membrane Nuclear Speck Cell Projection Perinuclear Region Of Cytoplasm Anchoring Junction
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Sequence-specific DNA Binding Metal Ion Binding	Transcription Coregulator Activity Protein Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus	Cell Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Substrate Adhesion-dependent Cell Spreading Endothelial Cell Migration Negative Regulation Of B Cell Receptor Signaling Pathway Protein-containing Complex Assembly
Pathways		Generic Transcription Pathway	None
GWAS		No GWAS studies recorded	Inflammatory bowel disease ( 23128233 ) Lymphoma ( 23349640 ) Pulse pressure ( 30578418 ) Ulcerative colitis ( 28067908 )
Interacting Genes		8 interacting genes: ALAS1 CDC42 KRTAP10-7 LPXN LZTR1 PSTPIP1 ZNF250 ZNF264	33 interacting genes: AGXT AQP1 GIT1 HDAC6 HOXA1 HOXC9 IKBKG IMP3 ITGA4 LIMS1 LMO1 LMO3 MAP2K7 MAPK6 NDN NR3C1 PHF21A PLEKHH2 PLEKHN1 PLSCR4 POM121 PTK2 PTK2B PTPN12 RNF214 RUNX1T1 SFI1 TGFB1 TNS2 TXLNB VCL ZNF175 ZNF426
Entrez ID		7728	9404
HPRD ID		03088	05651
Ensembl ID		ENSG00000105497	ENSG00000110031
Uniprot IDs		Q9Y473	B7Z5P7 O60711
PDB IDs		Not available	1X3H 4XEF 4XEK 4XEV
GO Terms Enriched among Interactors		None	Response To Dexamethasone Focal Adhesion Positive Regulation Of Fibroblast Migration Developmental Growth Developmental Growth Involved In Morphogenesis Anchoring Junction Cellular Response To Dexamethasone Stimulus Cellular Response To Lipid Cellular Response To Oxygen-containing Compound Multicellular Organismal-level Homeostasis Positive Regulation Of Mononuclear Cell Migration Regulation Of Fibroblast Migration Response To Fluid Shear Stress Developmental Cell Growth Response To Lipid Signal Complex Assembly Regulation Of Cell-matrix Adhesion Response To Glucocorticoid Regulation Of Fat Cell Differentiation Cellular Response To Glucocorticoid Stimulus Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Cellular Response To Growth Factor Stimulus Response To Corticosteroid Regulation Of RNA Metabolic Process Cellular Response To Transforming Growth Factor Beta Stimulus Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Corticosteroid Stimulus Anatomical Structure Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Focal Adhesion Assembly Regulation Of RNA Biosynthetic Process Response To Growth Factor Response To Transforming Growth Factor Beta Negative Regulation Of Nucleobase-containing Compound Metabolic Process ERBB Signaling Pathway Regulation Of Cell-substrate Junction Organization MAP Kinase Activity Regulation Of Primary Metabolic Process Regulation Of Cytoskeleton Organization Cellular Response To Steroid Hormone Stimulus Nucleus Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Neuron Projection Extension Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Cell Migration Positive Regulation Of Catabolic Process Response To Wounding