CNBP and PCBP2

Number of citations of the paper that reports this interaction (PubMedID 17327219)
0

Data Source:
HPRD (in vivo)

		CNBP	PCBP2
Description		CCHC-type zinc finger nucleic acid binding protein	poly(rC) binding protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Membrane Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Regulator Activity Metal Ion Binding G-quadruplex DNA Binding	Nucleic Acid Binding DNA Binding Single-stranded DNA Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Ubiquitin Protein Ligase Binding LncRNA Binding Promoter-enhancer Loop Anchoring Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G-quadruplex DNA Formation Positive Regulation Of Cytoplasmic Translation	Immune System Process Regulation Of Transcription By RNA Polymerase II MRNA Metabolic Process Viral RNA Genome Replication Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Negative Regulation Of Defense Response To Virus Defense Response To Virus IRES-dependent Viral Translational Initiation Chromatin Looping CGAS/STING Signaling Pathway Negative Regulation Of CGAS/STING Signaling Pathway
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	mRNA Splicing - Major Pathway Processing of Capped Intron-Containing Pre-mRNA Negative regulators of DDX58/IFIH1 signaling SARS-CoV-1 activates/modulates innate immune responses
Drugs
Diseases		Myotonic dystrophy (DM)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 27863252) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		4 interacting genes: CASP8 CDC42 HRH1 PCBP2	45 interacting genes: APOBEC3C BARD1 CASK CEBPA CNBP FLNA FOXP1 FTH1 GAR1 HMGA1 HMGA2 HNRNPD HNRNPK HNRNPL HNRNPR LINC01554 MECOM NKAP OGT PABPC1 PAXIP1 PCBP1 PDIA3 PRPF40A PTBP1 PTBP2 QKI RALYL RBFOX2 RBMX RBPMS SF3B2 SLC7A11 SLU7 SNRPA SRSF3 SRSF7 SUMO2 UBC UTP25 WDR77 WDR83 YBX1 YBX2 YBX3
Entrez ID		7555	5094
HPRD ID		00311	03129
Ensembl ID		ENSG00000169714	ENSG00000197111
Uniprot IDs		A0A0S2Z4K2 A0A0S2Z4Q3 P62633	A0A384N6B9 Q15366
PDB IDs			2AXY 2JZX 2P2R 2PQU 2PY9
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Ripoptosome Self Proteolysis Death Effector Domain Binding Response To Cobalt Ion Defense Response Regulation Of Cell Communication Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Death-inducing Signaling Complex Mononuclear Cell Differentiation CD95 Death-inducing Signaling Complex Ubiquitin Protein Ligase Binding TRAIL-activated Apoptotic Signaling Pathway Regulation Of Signaling Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuropilin Signaling Pathway Circulatory System Process GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cellular Response To Histamine Phospholipase C-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Viral RNA Genome Replication Promoter-enhancer Loop Anchoring Activity Response To Histamine IRES-dependent Viral Translational Initiation Leukocyte Differentiation Endothelin Receptor Signaling Pathway Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Macrophage Differentiation Regulation Of Innate Immune Response Death Receptor Binding Signal Transduction Golgi Localization Cardiac Conduction System Development	RNA Binding Nucleic Acid Binding MRNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process RNA Splicing MRNA Processing RNA Processing Nucleus Regulation Of MRNA Metabolic Process MRNA Metabolic Process Regulation Of MRNA Processing Negative Regulation Of MRNA Metabolic Process Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Metabolic Process Regulation Of RNA Splicing Negative Regulation Of Nucleobase-containing Compound Metabolic Process MRNA Splicing, Via Spliceosome Macromolecule Metabolic Process Nucleoplasm RNA Splicing, Via Transesterification Reactions Regulation Of RNA Metabolic Process Regulation Of Alternative MRNA Splicing, Via Spliceosome Positive Regulation Of Cytoplasmic Translation Spliceosomal Complex Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Gene Expression Catalytic Step 2 Spliceosome Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Splicing Regulation Of Primary Metabolic Process Negative Regulation Of Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Cytoplasmic Translation Ribonucleoprotein Complex Positive Regulation Of RNA Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II
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