CNBP and HRH1

Number of citations of the paper that reports this interaction (PubMedID 28298427)
90

Data Source:
BioGRID (two hybrid)

		CNBP	HRH1
Description		CCHC-type zinc finger nucleic acid binding protein	histamine receptor H1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol	Cytosol Plasma Membrane Membrane Dendrite Synapse
	Molecular Function	Nucleic Acid Binding DNA Binding RNA Binding Single-stranded RNA Binding MRNA Binding Protein Binding Zinc Ion Binding Translation Regulator Activity Metal Ion Binding G-quadruplex DNA Binding	G Protein-coupled Receptor Activity Histamine Receptor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Positive Regulation Of Cell Population Proliferation Cholesterol Homeostasis Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II G-quadruplex DNA Formation Positive Regulation Of Cytoplasmic Translation	Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating Serotonin Receptor Signaling Pathway Chemical Synaptic Transmission Memory Visual Learning Regulation Of Vascular Permeability Positive Regulation Of Vasoconstriction Regulation Of Synaptic Plasticity Cellular Response To Histamine
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses	Histamine receptors G alpha (q) signalling events
Drugs			Citalopram Benzatropine Ziprasidone Clemastine Amitriptyline Olanzapine Cetirizine Terfenadine Buclizine Clozapine Doxylamine Mirtazapine Dexbrompheniramine Loxapine Promazine Triprolidine Prochlorperazine Cyproheptadine Loratadine Imipramine Chlorpromazine Haloperidol Nortriptyline Amoxapine Lamotrigine Hydroxyzine Cinnarizine Astemizole Trazodone Paroxetine Azatadine Trimipramine Risperidone Meclizine Carbinoxamine Epinastine Benzquinamide Olopatadine Propiomazine Tripelennamine Tolazoline Brompheniramine Methdilazine Repaglinide Ketotifen Maprotiline Fexofenadine Desloratadine Azelastine Dimenhydrinate Promethazine Mequitazine Diphenhydramine Emedastine Levocabastine Chlorpheniramine Doxepin Diphenylpyraline Desipramine Orphenadrine Escitalopram Cyclizine Quetiapine Bromodiphenhydramine Aripiprazole Chlorprothixene Alimemazine Paliperidone Methotrimeprazine Aceprometazine Phenindamine Pheniramine Zuclopenthixol Clofedanol Flunarizine Bepotastine Tesmilifene Iloperidone HY10275 OBE101 SO-101 Histamine Epicept NP-1 Cariprazine Mianserin Pizotifen Asenapine Ocaperidone Levocetirizine Esmirtazapine Mepyramine Betahistine Alcaftadine Antazoline Chloropyramine Dimetindene Isothipendyl Perospirone Chlorcyclizine Butriptyline Dosulepin Viloxazine Lorpiprazole Acrivastine Dexchlorpheniramine maleate Thonzylamine Bilastine Rupatadine Aripiprazole lauroxil
Diseases		Myotonic dystrophy (DM)
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Male-pattern baldness ( 28196072) Mortality in sepsis ( 27639821) Pulse pressure ( 27841878) Systolic blood pressure ( 27618447 27618452 27841878)
Interacting Genes		4 interacting genes: CASP8 CDC42 HRH1 PCBP2	12 interacting genes: ACE2 ADGRA3 ATP6V0A1 CD81 CNBP DHRS7 LIMS2 MAT2B SLC35B1 SLC43A2 WLS YIPF3
Entrez ID		7555	3269
HPRD ID		00311	02544
Ensembl ID		ENSG00000169714	ENSG00000196639
Uniprot IDs		A0A0S2Z4K2 A0A0S2Z4Q3 P62633	P35367
PDB IDs			3RZE 7DFL 8YN2
Enriched GO Terms of Interacting Partners?		Macrophage Differentiation Positive Regulation Of Pyroptotic Inflammatory Response Response To Anesthetic Ripoptosome Self Proteolysis Death Effector Domain Binding Response To Cobalt Ion Defense Response Regulation Of Cell Communication Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Death-inducing Signaling Complex Mononuclear Cell Differentiation CD95 Death-inducing Signaling Complex Ubiquitin Protein Ligase Binding TRAIL-activated Apoptotic Signaling Pathway Regulation Of Signaling Myeloid Cell Differentiation Myeloid Leukocyte Differentiation Leading Edge Membrane Thioesterase Binding Positive Regulation Of Pinocytosis Apolipoprotein A-I Receptor Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Endothelin Receptor Signaling Pathway Involved In Heart Process Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuropilin Signaling Pathway Circulatory System Process GBD Domain Binding Golgi Transport Complex Storage Vacuole Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Cellular Response To Histamine Phospholipase C-activating Serotonin Receptor Signaling Pathway Histamine Receptor Activity Viral RNA Genome Replication Promoter-enhancer Loop Anchoring Activity Response To Histamine IRES-dependent Viral Translational Initiation Leukocyte Differentiation Endothelin Receptor Signaling Pathway Positive Regulation Of Pseudopodium Assembly Positive Regulation Of Macrophage Differentiation Regulation Of Innate Immune Response Death Receptor Binding Signal Transduction Golgi Localization Cardiac Conduction System Development	Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Virus Receptor Activity Myoblast Fusion Involved In Skeletal Muscle Regeneration G-quadruplex DNA Formation UDP-galactose Transmembrane Transport UDP-galactose Transmembrane Transporter Activity UDP-glucose Transmembrane Transporter Activity UDP-glucose Transmembrane Transport Methionine Adenosyltransferase Regulator Activity Methionine Adenosyltransferase Complex Cholangiocyte Proliferation Negative Regulation Of Hepatocyte Proliferation Regulation Of Cholangiocyte Proliferation Negative Regulation Of Cholangiocyte Proliferation Endocytic Vesicle Membrane Organic Cation Transport Positive Regulation Of L-proline Import Across Plasma Membrane Angiotensin-mediated Drinking Behavior Regulation Of Amine Transport Entry Receptor-mediated Virion Attachment To Host Cell Peptidyl-dipeptidase Activity Wnt Protein Secretion L-methionine Transmembrane Transporter Activity L-isoleucine Transmembrane Transporter Activity L-phenylalanine Transmembrane Transporter Activity Methionine Transport Negative Regulation Of L-leucine Import Across Plasma Membrane Organic Anion Transport Plasma Membrane Negative Regulation Of Transcription By RNA Polymerase III S-adenosylmethionine Biosynthetic Process Viral Translation Viral Life Cycle Positive Regulation Of Wnt Protein Secretion Phenylalanine Transport
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