CREBZF and HEY1

Number of citations of the paper that reports this interaction (PubMedID 22983008)
35

Data Source:
BioGRID (pull down)

		CREBZF	HEY1
Description		CREB/ATF bZIP transcription factor	hes related family bHLH transcription factor with YRPW motif 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Dimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus ATF6-mediated Unfolded Protein Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Integrated Stress Response Signaling	Negative Regulation Of Transcription By RNA Polymerase II Angiogenesis Cardiac Conduction System Development Aortic Valve Morphogenesis Pulmonary Valve Morphogenesis Atrioventricular Valve Formation Endocardial Cushion Morphogenesis Cardiac Ventricle Morphogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Notch Signaling Pathway Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Dorsal Aorta Morphogenesis Umbilical Cord Morphogenesis Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Neurogenesis Negative Regulation Of Smooth Muscle Cell Differentiation Cardiac Epithelial To Mesenchymal Transition Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Labyrinthine Layer Blood Vessel Development Arterial Endothelial Cell Differentiation Negative Regulation Of Biomineral Tissue Development Circulatory System Development Regulation Of Vasculogenesis
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants RUNX2 regulates osteoblast differentiation NOTCH3 Intracellular Domain Regulates Transcription NOTCH4 Intracellular Domain Regulates Transcription Cardiogenesis
Drugs
Diseases
GWAS		Refractive error ( 32231278)	Metastatic colorectal cancer survival in treatment with chemotherapy plus biologics ( 32958699)
Interacting Genes		19 interacting genes: ACYP2 ATF4 ATF6B BTG3 CTNNBL1 DSCR9 HCFC1 HEY1 LCOR NFE2L1 NFE2L2 NRIP1 RALBP1 RSPH1 TIAM1 TP53 TTC23 XBP1 ZNF512B	22 interacting genes: ARNT CREBZF DAZAP2 FBXW7 FOXH1 GATA1 HUNK KRTAP6-2 LAPTM5 MDM2 MYOD1 NTRK3 OLIG2 PITX2 PLEKHB2 PRKD2 SKIL SMAD3 SMAD9 TENT5D TP53 YTHDF1
Entrez ID		58487	23462
HPRD ID		07340	04260
Ensembl ID		ENSG00000137504	ENSG00000164683
Uniprot IDs		E9PIM0 Q9NS37	B4DEI9 Q9Y5J3
PDB IDs			2DB7
Enriched GO Terms of Interacting Partners?		ER-nucleus Signaling Pathway Cellular Response To Glucose Starvation Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Response To Endoplasmic Reticulum Stress DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription Cis-regulatory Region Binding Nuclear Estrogen Receptor Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Histone Deacetylase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm ATF6-mediated Unfolded Protein Response Response To Oxidative Stress Cellular Response To Starvation Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process PERK-mediated Unfolded Protein Response Promoter-specific Chromatin Binding Cellular Response To Oxidative Stress General Transcription Initiation Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Starvation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels DNA Binding Positive Regulation Of ERAD Pathway Cellular Response To Laminar Fluid Shear Stress DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Chemical Stress Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	Transcription Regulator Complex Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Biosynthetic Process Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Macromolecule Metabolic Process DNA-binding Transcription Factor Activity Positive Regulation Of Metabolic Process Positive Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II P53 Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Regulation Of RNA Metabolic Process Ubiquitin Protein Ligase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Lens Fiber Cell Differentiation Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Macromolecule Metabolic Process Regulation Of Cell Differentiation Regulation Of Primary Metabolic Process Response To Growth Factor Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Regulation Of Developmental Process Regulation Of Cell Population Proliferation Cellular Response To Actinomycin D Chromatin DNA Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway BHLH Transcription Factor Binding Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Multicellular Organismal Development Regulation Of Cell Development Regulation Of Metabolic Process Response To Actinomycin D Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cell Differentiation Negative Regulation Of Biosynthetic Process Response To Antibiotic Cellular Response To UV-C Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression
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