CREBZF and NFE2L1

Number of citations of the paper that reports this interaction (PubMedID 23661758)
48

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CREBZF	NFE2L1
Description		CREB/ATF bZIP transcription factor	NFE2 like bZIP transcription factor 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion RNA Polymerase II Transcription Regulator Complex	Chromatin Nucleus Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Protein-containing Complex
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Identical Protein Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Lipid Binding Cholesterol Binding Protein Domain Specific Binding Identical Protein Binding Protein-containing Complex Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Response To Virus ATF6-mediated Unfolded Protein Response Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-binding Transcription Factor Activity Integrated Stress Response Signaling	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Fructose 6-phosphate Metabolic Process Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Lipid Metabolic Process Glutathione Metabolic Process Heme Biosynthetic Process Regulation Of Mitotic Nuclear Division Steroid Metabolic Process Cholesterol Metabolic Process Anatomical Structure Morphogenesis Regulation Of Gene Expression Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cellular Homeostasis Spinal Cord Motor Neuron Differentiation Glial Cell Fate Commitment Erythrocyte Differentiation Cellular Response To Oxidative Stress Response To Endoplasmic Reticulum Stress Cholesterol Homeostasis Cysteine Transport Cell Redox Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Inflammatory Response Glucose 6-phosphate Metabolic Process Lipid Homeostasis Regulation Of Proteasomal Protein Catabolic Process Cellular Response To Cold Cellular Response To Copper Ion Cellular Response To Cholesterol Regulation Of Odontoblast Differentiation Regulation Of Nucleus Organization Regulation Of Response To Endoplasmic Reticulum Stress
Pathways
Drugs			Dodecyldimethylamine N-oxide
Diseases
GWAS		Refractive error ( 32231278)	Aspartate aminotransferase levels ( 33547301) Fasting glucose ( 34059833) Generalized epilepsy ( 22949513) Heel bone mineral density ( 30598549) Hematocrit ( 32888494) Red blood cell count ( 32888494)
Interacting Genes		19 interacting genes: ACYP2 ATF4 ATF6B BTG3 CTNNBL1 DSCR9 HCFC1 HEY1 LCOR NFE2L1 NFE2L2 NRIP1 RALBP1 RSPH1 TIAM1 TP53 TTC23 XBP1 ZNF512B	17 interacting genes: ATF4 BACH2 CAPN1 CD6 CREBZF GSK3B HCFC1 JUN JUNB JUND MAFF MAFG MAFK NFE2L3 PARVA TULP3 UBE4A
Entrez ID		58487	4779
HPRD ID		07340	01223
Ensembl ID		ENSG00000137504	ENSG00000082641
Uniprot IDs		E9PIM0 Q9NS37	J9JIE5 Q14494
PDB IDs
Enriched GO Terms of Interacting Partners?		ER-nucleus Signaling Pathway Cellular Response To Glucose Starvation Response To Endoplasmic Reticulum Stress Negative Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Response To Endoplasmic Reticulum Stress DNA-binding Transcription Factor Activity Negative Regulation Of RNA Metabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Transcription Cis-regulatory Region Binding Nuclear Estrogen Receptor Binding Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Transcription Regulator Complex Histone Deacetylase Binding Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Nucleoplasm ATF6-mediated Unfolded Protein Response Response To Oxidative Stress Cellular Response To Starvation Regulation Of Intrinsic Apoptotic Signaling Pathway RNA Polymerase II-specific DNA-binding Transcription Factor Binding Positive Regulation Of RNA Metabolic Process PERK-mediated Unfolded Protein Response Promoter-specific Chromatin Binding Cellular Response To Oxidative Stress General Transcription Initiation Factor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Starvation Chromatin DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Response To Nutrient Levels DNA Binding Positive Regulation Of ERAD Pathway Cellular Response To Laminar Fluid Shear Stress DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Cellular Response To Chemical Stress Negative Regulation Of Macromolecule Biosynthetic Process Intracellular Signaling Cassette Nucleus Negative Regulation Of Intrinsic Apoptotic Signaling Pathway	RNA Polymerase II Transcription Regulator Complex DNA-binding Transcription Factor Activity Integrated Stress Response Signaling RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Factor AP-1 Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Chromatin Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Sequence-specific Double-stranded DNA Binding Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Biosynthetic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Response To Endoplasmic Reticulum Stress Regulation Of Gene Expression Negative Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process ER-nucleus Signaling Pathway DNA Binding Regulation Of Metabolic Process Positive Regulation Of RNA Biosynthetic Process Negative Regulation Of Metabolic Process Positive Regulation Of DNA-templated Transcription Release From Viral Latency Positive Regulation Of RNA Metabolic Process Cellular Response To Metal Ion Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleoplasm Cellular Response To Calcium Ion Positive Regulation Of Biosynthetic Process Cellular Response To Stress Regulation Of Primary Metabolic Process General Transcription Initiation Factor Binding Transcription Regulator Complex Transcription Cis-regulatory Region Binding Intracellular Signaling Cassette DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Nucleus Positive Regulation Of Macromolecule Metabolic Process
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