KRTAP12-3 and PTGDS

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KRTAP12-3	PTGDS
Description		keratin associated protein 12-3	prostaglandin D2 synthase
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol Intermediate Filament Keratin Filament	Extracellular Region Extracellular Space Nucleus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Rough Endoplasmic Reticulum Golgi Apparatus Membrane Nuclear Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Identical Protein Binding	Prostaglandin-D Synthase Activity Retinoid Binding Fatty Acid Binding Protein Binding Isomerase Activity Small Molecule Binding
	Biological Process		Prostaglandin Biosynthetic Process Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Prostaglandin Metabolic Process Gene Expression Mast Cell Degranulation Regulation Of Circadian Sleep/wake Cycle, Sleep Prostanoid Biosynthetic Process Response To Glucocorticoid Negative Regulation Of Male Germ Cell Proliferation
Pathways		Keratinization	Synthesis of Prostaglandins (PG) and Thromboxanes (TX) Transcriptional regulation of testis differentiation
Drugs			Vitamin A
Diseases
GWAS			Beta-trace protein levels ( 23328707) Corneal structure ( 23291589) Keratoconus ( 33649486)
Interacting Genes		145 interacting genes: ADAMTSL3 ADAMTSL4 AGXT ALDH3B1 BCL6B BMP7 C11orf87 C22orf39 CARD10 CATSPER1 CBX2 CELF5 CHIC2 CHRD CHRNG CNNM3 COL8A1 CRCT1 CREB5 CYSRT1 DALRD3 DHRS1 DHX57 DNAL4 DOCK2 FASLG FBXW5 GLRX3 GNE GTF3C5 HOXA1 ITGB4 JOSD1 KPRP KRT20 KRTAP1-1 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP11-1 KRTAP12-1 KRTAP13-1 KRTAP13-2 KRTAP13-3 KRTAP19-7 KRTAP3-3 KRTAP4-2 KRTAP4-4 KRTAP5-6 KRTAP5-9 KRTAP6-1 KRTAP6-2 KRTAP9-2 KRTAP9-3 LCE1A LCE1B LCE1C LCE1D LCE1E LCE1F LCE2A LCE2B LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE4A LCE5A LIF LMNTD2 LNX1 LYVE1 MAPKBP1 MEOX2 MISP MOBP NBPF19 NKD1 NMU NOTCH2NLA NPDC1 NR1D2 NR4A3 NUFIP2 OTX1 OXER1 P2RX4 P2RY6 P3H3 P4HB PDE9A PDGFRB PGAP6 PHLDA1 POU4F2 PTGDS PTPMT1 R3HDM2 RSPO2 SELENOM SHFL SLC13A5 SLC15A2 SLC23A1 SMCP SPATA3 SPRY1 TCEA2 TCEANC TFAP2D TMIE TNP2 TNS2 TTPA UTP23 UXT VASN VGLL3 VSTM4 WDR25 WNT11 YY1 ZDHHC1 ZNF101 ZNF124 ZNF138 ZNF20 ZNF408 ZNF417 ZNF439 ZNF440 ZNF467 ZNF490 ZNF491 ZNF497 ZNF578 ZNF587 ZNF648 ZNF696 ZNF80 ZNF835 ZNF837 ZSCAN21	23 interacting genes: ADRB2 AKT1 ARRB2 ATXN1 BCAT2 CACNA1A CAPN1 CARD10 CYSRT1 EGFR GGA3 HK2 HK3 HSP90AA1 KRTAP10-3 KRTAP10-7 KRTAP12-3 MLH1 PTGER1 PTGER2 PTGFR SHBG UBQLN2
Entrez ID		386683	5730
HPRD ID		11199	08904
Ensembl ID		ENSG00000205439	ENSG00000107317
Uniprot IDs		P60328	A0A024R8G3 P41222
PDB IDs			2WWP 3O19 3O22 3O2Y 4IMN 4IMO 4ORR 4ORS 4ORU 4ORW 4ORX 4ORY 4OS0 4OS3 4OS8 5WY9 8HTA
Enriched GO Terms of Interacting Partners?		Keratinization Intermediate Filament Epidermis Development Keratin Filament Protein Binding Tissue Development DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Regulation Of Transcription By RNA Polymerase II Identical Protein Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding	Regulation Of Macroautophagy Response To Prostaglandin E Cellular Response To Prostaglandin Stimulus Hexokinase Activity Glucokinase Activity Fructokinase Activity Beta-arrestin-dependent Dopamine Receptor Signaling Pathway Maintenance Of Protein Location In Mitochondrion Prostaglandin E Receptor Activity Glutamate Receptor Signaling Pathway Regulation Of Biological Quality Nitric-oxide Synthase Regulator Activity D1 Dopamine Receptor Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Catabolic Process Excitatory Postsynaptic Potential D-glucose Binding Catabolic Process Regulation Of Autophagy Regulation Of Protein Catabolic Process Phosphotransferase Activity, Alcohol Group As Acceptor Establishment Of Protein Localization To Mitochondrion Response To UV-A Enzyme Binding Fructose 6-phosphate Metabolic Process Positive Regulation Of Protein Catabolic Process Response To Ketone Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Identical Protein Binding Cellular Response To Prostaglandin E Stimulus Regulation Of Postsynaptic Membrane Potential Response To Alcohol Macromolecule Catabolic Process Negative Regulation Of Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Positive Regulation Of Peptidyl-serine Phosphorylation Glycolytic Process Through Glucose-6-phosphate Carbohydrate Phosphorylation Glucose 6-phosphate Metabolic Process Glycolytic Process Through Fructose-6-phosphate Canonical Glycolysis Keratin Filament Positive Regulation Of DNA Metabolic Process Positive Regulation Of Protein Metabolic Process Ficolin-1-rich Granule Lumen Positive Regulation Of Metabolic Process Glucose Metabolic Process Glucose Catabolic Process Ionotropic Glutamate Receptor Signaling Pathway
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