ROR2 and FZD2

Number of citations of the paper that reports this interaction (PubMedID 12839624)
0

Data Source:
HPRD (in vitro, in vivo)

		ROR2	FZD2
Description		receptor tyrosine kinase like orphan receptor 2	frizzled class receptor 2
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GO Annotations	Cellular Component	Plasma Membrane Membrane Axon Clathrin-coated Endocytic Vesicle Membrane Receptor Complex	Cytoplasm Plasma Membrane Focal Adhesion Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Coreceptor Activity Kinase Activity Transferase Activity Wnt-protein Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Metal Ion Binding	Transmembrane Signaling Receptor Activity G Protein-coupled Receptor Activity Protein Binding Wnt-protein Binding PDZ Domain Binding Wnt Receptor Activity
	Biological Process	Signal Transduction Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Wnt Signaling Pathway Positive Regulation Of Cell Migration	Membranous Septum Morphogenesis Muscular Septum Morphogenesis Outflow Tract Morphogenesis Signal Transduction Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Sensory Perception Of Smell Wnt Signaling Pathway Neuron Differentiation Non-canonical Wnt Signaling Pathway Endothelial Cell Differentiation Positive Regulation Of DNA-templated Transcription Hard Palate Development Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Inner Ear Receptor Cell Development Ventricular Septum Morphogenesis Cochlea Morphogenesis
Pathways		PCP/CE pathway WNT5A-dependent internalization of FZD2, FZD5 and ROR2	TCF dependent signaling in response to WNT Class B/2 (Secretin family receptors) Ca2+ pathway Ca2+ pathway Asymmetric localization of PCP proteins Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD2, FZD5 and ROR2
Drugs
Diseases		Robinow syndrome Brachydactyly, including: type A; type B; type D; type E
GWAS		Bipolar disorder (inflammation and infection response interaction) ( 25781172) Bipolar disorder and schizophrenia ( 22688191) Birth weight ( 31043758) Bone mineral density (hip) ( 26911590) Facial morphology ( 31763980) Iris color (L* coordinate) ( 30895295) Nose size ( 27182965) Offspring birth weight ( 31043758) Serum immune biomarker levels ( 32066700) Type 2 diabetes ( 25483131)	Brain morphology (MOSTest) ( 32665545) Pulse pressure ( 30224653)
Interacting Genes		73 interacting genes: ACTMAP ALG13 ARID5A ATXN7L1 BHLHE40 C10orf55 C1orf94 CDC14A CDC25C CREM CRX DAB1 DAZAP2 DUSP1 DUSP10 DUSP14 DUSP18 DUSP19 DUSP21 DUSP29 DUSP6 ERBB2 EYA2 FAM168B FOSB FZD2 FZD5 HIVEP1 IKBKG ILKAP ISX KRTAP19-7 KRTAP6-2 KRTAP7-1 LHX6 MAGED1 MAP3K7 MTMR1 MTMR2 MTMR6 MTMR9 PITX1 PLA2G10 POU2AF1 PPM1A PPM1B PPM1F PPP3CB PRKAB2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23E PTPN11 PTPN12 PTPN20 PTPN6 PTPN7 PTPRR RBPMS SOX14 STOX1 STYX TAB1 TENT5A TLX3 TPTE VENTX WNT5A ZMYM4 ZNF34	2 interacting genes: DLG4 ROR2
Entrez ID		4920	2535
HPRD ID		03822	02813
Ensembl ID		ENSG00000169071	ENSG00000180340
Uniprot IDs		Q01974	Q14332 Q86UZ8
PDB IDs		3ZZW 4GT4 6OSH 6OSN 6OSV 9FSE	6C0B 7N95 7N97 7N9S 7X8P
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation Hydrolase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Phosphate-containing Compound Metabolic Process Non-membrane Spanning Protein Tyrosine Phosphatase Activity Cation Binding Calmodulin-dependent Protein Phosphatase Activity Regulation Of Phosphatidylinositol Dephosphorylation Intracellular Signaling Cassette Phosphatidylinositol Dephosphorylation Regulation Of ERK1 And ERK2 Cascade Regulation Of MAPK Cascade Peptidyl-threonine Dephosphorylation MAPK Cascade Negative Regulation Of MAPK Cascade Positive Regulation Of Macromolecule Biosynthetic Process Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Phospholipid Dephosphorylation Positive Regulation Of Biosynthetic Process Phosphatidylinositol-3-phosphate Phosphatase Activity Positive Regulation Of Metabolic Process Sequence-specific Double-stranded DNA Binding Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Linear Polyubiquitin Binding Regulation Of Metabolic Process N-terminal Protein Myristoylation Protein Serine/threonine Kinase Binding Regulation Of DNA-templated Transcription Regulation Of Dephosphorylation Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Metabolic Process Neuron Differentiation Negative Regulation Of Signaling Receptor Tyrosine Kinase Binding Protein Binding Regulation Of Protein Serine/threonine Kinase Activity Phosphatidylinositol Phosphate Phosphatase Activity Positive Regulation Of Nucleobase-containing Compound Metabolic Process	Cerebellar Mossy Fiber Synaptic Vesicle Maturation P2Y1 Nucleotide Receptor Binding Axon Neuron Spine Positive Regulation Of Neuron Projection Arborization AMPA Glutamate Receptor Clustering Beta-1 Adrenergic Receptor Binding D1 Dopamine Receptor Binding Regulation Of Grooming Behavior NMDA Selective Glutamate Receptor Signaling Pathway Neuroligin Family Protein Binding Juxtaparanode Region Of Axon Neuron Projection Terminus Locomotory Exploration Behavior Cellular Response To Potassium Ion Regulation Of Neuron Projection Arborization Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Dendritic Spine Morphogenesis Acetylcholine Receptor Binding Neurotransmitter-gated Ion Channel Clustering Negative Regulation Of Receptor Internalization Mitogen-activated Protein Kinase Kinase Kinase Binding Response To Potassium Ion Vocalization Behavior Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Cortical Cytoskeleton Ionotropic Glutamate Receptor Binding AMPA Glutamate Receptor Complex Ionotropic Glutamate Receptor Signaling Pathway Dendritic Spine Organization Dendrite Cytoplasm Negative Regulation Of Receptor-mediated Endocytosis Regulation Of Long-term Neuronal Synaptic Plasticity Excitatory Synapse Wnt-protein Binding Protein Localization To Postsynapse Exploration Behavior Organelle Ligand-gated Ion Channel Signaling Pathway Neuron Projection Organization Postsynapse Organization Receptor Clustering Glutamate Receptor Signaling Pathway Neuromuscular Process Controlling Balance Modulation Of Excitatory Postsynaptic Potential Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Receptor Localization To Synapse
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