Wiki-Pi
About
Search
People
Updates
Search
ROR2 and DUSP1
Number of citations of the paper that reports this interaction (PubMedID
28065597
)
51
Data Source:
BioGRID
(two hybrid)
ROR2
DUSP1
Description
receptor tyrosine kinase like orphan receptor 2
dual specificity phosphatase 1
Image
GO Annotations
Cellular Component
Plasma Membrane
Membrane
Axon
Clathrin-coated Endocytic Vesicle Membrane
Receptor Complex
Nucleus
Cytoplasm
Molecular Function
Nucleotide Binding
Protein Kinase Activity
Protein Tyrosine Kinase Activity
Transmembrane Receptor Protein Tyrosine Kinase Activity
Protein Binding
ATP Binding
Coreceptor Activity
Kinase Activity
Transferase Activity
Wnt-protein Binding
Mitogen-activated Protein Kinase Kinase Kinase Binding
Metal Ion Binding
Phosphoprotein Phosphatase Activity
Protein Serine/threonine Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Protein Binding
Protein Tyrosine/serine/threonine Phosphatase Activity
Hydrolase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Growth Factor Binding
Mitogen-activated Protein Kinase Binding
Biological Process
Signal Transduction
Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway
Wnt Signaling Pathway
Positive Regulation Of Cell Migration
Endoderm Formation
Negative Regulation Of Cell Adhesion
Signal Transduction
Negative Regulation Of Cell Population Proliferation
Response To Light Stimulus
Response To Estradiol
Response To Retinoic Acid
Cellular Response To Hormone Stimulus
Response To Testosterone
Peptidyl-tyrosine Dephosphorylation
Intracellular Signal Transduction
Peptidyl-threonine Dephosphorylation
Response To Hydrogen Peroxide
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of MAP Kinase Activity
Negative Regulation Of MAPK Cascade
Response To Glucocorticoid
Negative Regulation Of Meiotic Cell Cycle
Response To CAMP
Response To Calcium Ion
Peptidyl-serine Dephosphorylation
ERK1 And ERK2 Cascade
Negative Regulation Of ERK1 And ERK2 Cascade
Negative Regulation Of Monocyte Chemotaxis
Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint
Negative Regulation Of P38MAPK Cascade
Cellular Response To Chemokine
Negative Regulation Of DNA Biosynthetic Process
Pathways
PCP/CE pathway
WNT5A-dependent internalization of FZD2, FZD5 and ROR2
RAF-independent MAPK1/3 activation
Negative regulation of MAPK pathway
Drugs
Diseases
Robinow syndrome
Brachydactyly, including: type A; type B; type D; type E
GWAS
Bipolar disorder (inflammation and infection response interaction) (
25781172
)
Bipolar disorder and schizophrenia (
22688191
)
Birth weight (
31043758
)
Bone mineral density (hip) (
26911590
)
Facial morphology (
31763980
)
Iris color (L* coordinate) (
30895295
)
Nose size (
27182965
)
Offspring birth weight (
31043758
)
Serum immune biomarker levels (
32066700
)
Type 2 diabetes (
25483131
)
C-reactive protein levels (
30388399
)
Diastolic blood pressure (
30224653
)
Inflammatory bowel disease (
26192919
)
Metabolite levels (
23823483
)
Offspring birth weight (
31043758
)
Optic cup area (
28073927
)
Ulcerative colitis (
26192919
)
Vertical cup-disc ratio (
25241763
28073927
31798171
)
Vertical cup-disc ratio (adjusted for vertical disc diameter) (
31959993
)
Vertical cup-disc ratio (multi-trait analysis) (
31959993
)
Interacting Genes
73 interacting genes:
ACTMAP
ALG13
ARID5A
ATXN7L1
BHLHE40
C10orf55
C1orf94
CDC14A
CDC25C
CREM
CRX
DAB1
DAZAP2
DUSP1
DUSP10
DUSP14
DUSP18
DUSP19
DUSP21
DUSP29
DUSP6
ERBB2
EYA2
FAM168B
FOSB
FZD2
FZD5
HIVEP1
IKBKG
ILKAP
ISX
KRTAP19-7
KRTAP6-2
KRTAP7-1
LHX6
MAGED1
MAP3K7
MTMR1
MTMR2
MTMR6
MTMR9
PITX1
PLA2G10
POU2AF1
PPM1A
PPM1B
PPM1F
PPP3CB
PRKAB2
PRR20A
PRR20B
PRR20C
PRR20D
PRR20E
PRR23E
PTPN11
PTPN12
PTPN20
PTPN6
PTPN7
PTPRR
RBPMS
SOX14
STOX1
STYX
TAB1
TENT5A
TLX3
TPTE
VENTX
WNT5A
ZMYM4
ZNF34
15 interacting genes:
AATK
CKS1B
HSPA4
HSPB2
MAPK1
MAPK12
MAPK14
MAPK3
MAPK8
MAPT
POLR1H
ROR2
SKP2
STAMBPL1
UBB
Entrez ID
4920
1843
HPRD ID
03822
02835
Ensembl ID
ENSG00000169071
ENSG00000120129
Uniprot IDs
Q01974
B4DU40
P28562
PDB IDs
3ZZW
4GT4
6OSH
6OSN
6OSV
9FSE
6APX
6D65
6D66
6D67
Enriched GO Terms of Interacting Partners
?
Phosphoprotein Phosphatase Activity
Protein Tyrosine Phosphatase Activity
Dephosphorylation
Protein Serine/threonine Phosphatase Activity
Protein Dephosphorylation
Peptidyl-tyrosine Dephosphorylation
Hydrolase Activity
MAP Kinase Tyrosine/serine/threonine Phosphatase Activity
Protein Tyrosine/serine/threonine Phosphatase Activity
Phosphate-containing Compound Metabolic Process
Non-membrane Spanning Protein Tyrosine Phosphatase Activity
Cation Binding
Calmodulin-dependent Protein Phosphatase Activity
Regulation Of Phosphatidylinositol Dephosphorylation
Intracellular Signaling Cassette
Phosphatidylinositol Dephosphorylation
Regulation Of ERK1 And ERK2 Cascade
Regulation Of MAPK Cascade
Peptidyl-threonine Dephosphorylation
MAPK Cascade
Negative Regulation Of MAPK Cascade
Positive Regulation Of Macromolecule Biosynthetic Process
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase Activity
Negative Regulation Of ERK1 And ERK2 Cascade
Phospholipid Dephosphorylation
Positive Regulation Of Biosynthetic Process
Phosphatidylinositol-3-phosphate Phosphatase Activity
Positive Regulation Of Metabolic Process
Sequence-specific Double-stranded DNA Binding
Regulation Of Macromolecule Metabolic Process
Positive Regulation Of Macromolecule Metabolic Process
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
Linear Polyubiquitin Binding
Regulation Of Metabolic Process
N-terminal Protein Myristoylation
Protein Serine/threonine Kinase Binding
Regulation Of DNA-templated Transcription
Regulation Of Dephosphorylation
Regulation Of RNA Biosynthetic Process
Regulation Of Primary Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Positive Regulation Of RNA Metabolic Process
Neuron Differentiation
Negative Regulation Of Signaling
Receptor Tyrosine Kinase Binding
Protein Binding
Regulation Of Protein Serine/threonine Kinase Activity
Phosphatidylinositol Phosphate Phosphatase Activity
Positive Regulation Of Nucleobase-containing Compound Metabolic Process
MAP Kinase Activity
Stress-activated MAPK Cascade
Stress-activated Protein Kinase Signaling Cascade
Protein Kinase Activity
Cellular Response To Amino Acid Starvation
Response To Amino Acid Starvation
Protein Serine Kinase Activity
Kinase Activity
Protein Serine/threonine Kinase Activity
Positive Regulation Of Cyclase Activity
MAPK Cascade
Interleukin-34-mediated Signaling Pathway
Lipopolysaccharide-mediated Signaling Pathway
Regulation Of Golgi Inheritance
ATP Binding
Caveolin-mediated Endocytosis
Positive Regulation Of Macrophage Proliferation
Cardiac Neural Crest Cell Development Involved In Heart Development
Trachea Formation
Cellular Response To Starvation
Outer Ear Morphogenesis
ERBB3 Signaling Pathway
ERBB2-ERBB3 Signaling Pathway
Energy Homeostasis
DNA Damage Response
Nucleotide Binding
Bergmann Glial Cell Differentiation
Response To Starvation
Response To Nutrient Levels
Response To Stress
Cellular Response To Nutrient Levels
Cellular Response To Tumor Necrosis Factor
Regulation Of Golgi Organization
Pseudopodium
Regulation Of Early Endosome To Late Endosome Transport
Response To Lipopolysaccharide
Schwann Cell Development
Response To Growth Factor
Positive Regulation Of Macrophage Chemotaxis
Regulation Of Ossification
Response To Tumor Necrosis Factor
Response To Molecule Of Bacterial Origin
Face Development
Positive Regulation Of Neuroinflammatory Response
Peptidyl-threonine Phosphorylation
Animal Organ Formation
Cellular Response To Stress
ERBB2 Signaling Pathway
Mitochondrion Transport Along Microtubule
Positive Regulation Of Macrophage Migration
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?