NELFA and NELFCD

Number of citations of the paper that reports this interaction (PMID 12612062)
52

Data Source:
HPRD (in vitro)

		NELFA	NELFCD
Gene Name		negative elongation factor complex member A	negative elongation factor complex member C/D
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm NELF Complex	Nucleoplasm Membrane NELF Complex
	Molecular Function	Chromatin Binding Protein Binding	Protein Binding
	Biological Process	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Multicellular Organismal Development Gene Expression Viral Process Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Viral Transcription	Transcription From RNA Polymerase II Promoter Transcription Elongation From RNA Polymerase II Promoter Gene Expression Viral Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Transcription
Pathways		Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation	Formation of HIV-1 elongation complex containing HIV-1 Tat RNA Polymerase II Transcription Abortive elongation of HIV-1 transcript in the absence of Tat HIV Infection Formation of the Early Elongation Complex Tat-mediated elongation of the HIV-1 transcript Tat-mediated HIV elongation arrest and recovery RNA Polymerase II Pre-transcription Events Late Phase of HIV Life Cycle Pausing and recovery of Tat-mediated HIV elongation Formation of RNA Pol II elongation complex HIV elongation arrest and recovery HIV Life Cycle Pausing and recovery of HIV elongation Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex HIV Transcription Elongation Transcription of the HIV genome RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Protein-Protein Interactions		6 interactors: APP NELFB NELFCD POLR2A PRR22 SIAH1	19 interactors: AAMP AR ARAF ARPC4 CACNA1A DNAJA1 ENDOV EPRS FRMD5 GSTM4 HDAC11 MTA1 NELFA PRMT5 SERF2 SMAD4 TXK UBE3A ZNF638
Entrez ID		7469	51497
HPRD ID		12080	16096
Ensembl ID		ENSG00000185049	ENSG00000101158
Uniprot IDs		B3KSP0 Q9H3P2	H0UI80 Q8IXH7
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Viral Transcription Transcription Elongation From RNA Polymerase II Promoter Regulation Of Viral Transcription Positive Regulation Of Viral Process DNA-templated Transcription, Elongation Regulation Of Viral Process Neuron Apoptotic Process Neuron Death Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Viral Process Regulation Of Gene Expression Transcription, RNA-templated Synaptic Growth At Neuromuscular Junction Transcription From RNA Polymerase II Promoter Collateral Sprouting In Absence Of Injury Positive Regulation Of Cellular Metabolic Process Collateral Sprouting Axon Midline Choice Point Recognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition RNA Metabolic Process Neuron Remodeling Positive Regulation Of Metabolic Process Gene Expression Axon Guidance MRNA Processing Regulation Of Metabolic Process Posttranscriptional Regulation Of Gene Expression Cellular Copper Ion Homeostasis Cell Development Regulation Of Transcription, DNA-templated Copper Ion Homeostasis Suckling Behavior Axonogenesis Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process MRNA Metabolic Process Protein Destabilization Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of RNA Metabolic Process Axon Development RNA Processing Cell Morphogenesis Involved In Neuron Differentiation Nucleobase-containing Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process Chemotaxis Neuron Maturation MRNA Polyadenylation	Androgen Receptor Signaling Pathway Endothelial Cell Activation Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process RNA Metabolic Process Transcription, DNA-templated Nitrogen Compound Metabolic Process RNA Biosynthetic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Intracellular Receptor Signaling Pathway Growth Regulation Of Protein Ubiquitination Gene Expression Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Cell Death Cellular Macromolecule Biosynthetic Process Negative Regulation Of Integrin Biosynthetic Process Cerebellar Molecular Layer Development Sperm Entry Positive Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Regulation Of Metabolic Process Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cellular Response To Stimulus Cellular Metabolic Process Prostate Gland Development Heterocycle Metabolic Process Biosynthetic Process Prolyl-tRNA Aminoacylation Vestibular Nucleus Development Peptidyl-arginine Methylation, To Symmetrical-dimethyl Arginine Nephrogenic Mesenchyme Morphogenesis Positive Regulation Of Protein Autoubiquitination Regulation Of Establishment Of Protein Localization Rhythmic Process Circadian Regulation Of Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Glutamyl-tRNA Aminoacylation Positive Regulation Of Integrin Biosynthetic Process Cerebellum Maturation Nephrogenic Mesenchyme Development Metanephric Mesenchyme Morphogenesis Musculoskeletal Movement, Spinal Reflex Action Regulation Of Protein Autoubiquitination NK T Cell Differentiation Positive Regulation Of Cellular Metabolic Process Cellular Component Assembly
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