NELFA

Description		negative elongation factor complex member A
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Nuclear Body NELF Complex
	Molecular Function	Chromatin Binding Protein Binding Molecular Adaptor Activity
	Biological Process	Negative Regulation Of Transcription Elongation By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation
Drugs
Diseases
GWAS
Novel Interacting Genes		1 novel interacting genes: NSD2
Interacting Genes		12 interacting genes: APP CDK3 CEBPA MLH1 NCK2 NELFCD OPRM1 PIN1 PRR22 SH3KBP1 SIAH1 SMARCD1
Entrez ID		7469
HPRD ID		12080
Ensembl ID		ENSG00000185049
Uniprot IDs		A0A0C4DFX9 Q9H3P2
PDB IDs		5L3X 6GML 7PKS 7YCX 8RBX 8UHA 8UHD 8UHG 8UI0 8UIS 8W8E 9J0N 9J0O 9J0P
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cell Activation Regulation Of Cell Activation Positive Regulation Of Immune System Process Positive Regulation Of Lymphocyte Activation Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Isotype Switching To IgA Isotypes Chromatin Binding Supramolecular Fiber Organization Regulation Of Lymphocyte Activation Regulation Of Cellular Response To Stress Positive Regulation Of B Cell Activation Regulation Of Immune System Process Regulation Of B Cell Activation Positive Regulation Of Gene Expression Positive Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Isotype Switching Amyloid Fibril Formation Positive Regulation Of Developmental Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Regulation Of Isotype Switching Positive Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of Multicellular Organismal Process Regulation Of Mitotic Cell Cycle Positive Regulation Of Immunoglobulin Mediated Immune Response Negative Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Gene Expression, Epigenetic Amyloid-beta Complex Regulation Of Amyloid Precursor Protein Catabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Stress RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Morphine Receptor Activity Negative Regulation Of Wnt Protein Secretion Beta-endorphin Receptor Activity Cis-trans Isomerase Activity Regulation Of Cell Cycle Regulation Of Developmental Process Positive Regulation Of Immunoglobulin Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Positive Regulation Of DNA Metabolic Process
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