POMP and CAPN3

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		POMP	CAPN3
Description		proteasome maturation protein	calpain 3
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Membrane Nuclear Speck	Nucleus Nucleolus Cytoplasm Cytosol Plasma Membrane Myofibril Z Disc T-tubule Protein-containing Complex
	Molecular Function	Protein Binding	Catalytic Activity Calcium-dependent Cysteine-type Endopeptidase Activity Calcium Ion Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Structural Constituent Of Muscle Hydrolase Activity Sodium Ion Binding Titin Binding Identical Protein Binding Metal Ion Binding Ligase Regulator Activity Molecular Adaptor Activity
	Biological Process	Proteasome Assembly	Proteolysis Apoptotic Process Muscle Organ Development Programmed Cell Death Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Response To Muscle Activity Protein Catabolic Process Myofibril Assembly Protein Destabilization Negative Regulation Of Protein Sumoylation Negative Regulation Of Apoptotic Process Regulation Of Canonical NF-kappaB Signal Transduction Sarcomere Organization Regulation Of Myoblast Differentiation Positive Regulation Of Proteolysis Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Muscle Cell Cellular Homeostasis Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Response To Calcium Ion Muscle Structure Development Protein-containing Complex Assembly G1 To G0 Transition Involved In Cell Differentiation Cellular Response To Calcium Ion Cellular Response To Salt Stress Protein Localization To Membrane Self Proteolysis Calcium-dependent Self Proteolysis
Pathways		Proteasome assembly Proteasome assembly	Degradation of the extracellular matrix
Drugs			L-aminocarnityl-succinyl-leucyl-argininal-diethylacetal
Diseases		Keratosis linearis with ichthyosis congenita and sclerosing keratoderma; KLICK syndrome	Limb-girdle muscular dystrophy (LGMD) Calpainopathy; Limb-girdle muscular dystrophy 2A (LGMD2A)
GWAS		Breast cancer (menopausal hormone therapy interaction) ( 24080446) Hematocrit ( 27863252 32888494) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Red blood cell count ( 32888494) Refractive error ( 32231278)	Fibrinogen levels ( 26561523 28107422) Granulocyte percentage of myeloid white cells ( 27863252) HDL cholesterol levels ( 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Monocyte count ( 27863252 32888494) Monocyte percentage of white cells ( 27863252 32888494) Triglyceride levels ( 30698716 32203549) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglycerides ( 25961943 24097068 20686565)
Interacting Genes		24 interacting genes: ATXN1 CAPN3 DCPH1 ECT2 FAM107A GPD1 GRB2 KCNA10 KIF1B KLHL41 MPPED2 PSMA3 PSMB1 PSMB10 PSMB5 PSMB6 PSMB7 PSMB8 PSMB9 PYGM RBM5 SSR4 TTN VCL	32 interacting genes: AMOT C1QTNF9 CCDC102B CEP76 CMYA5 CRYAB DYSF EXOC8 FLNC FNDC3B FXR1 GTPBP3 KANK2 MAP1LC3C MMP2 MYBPC1 MYBPH NECAB2 NTAQ1 OSGIN1 POMP PREPL PSMC3 PSMD1 RNF167 RUFY3 TFCP2 TRIM55 TRIM63 TTN UBE3A YWHAQ
Entrez ID		51371	825
HPRD ID		12613	00255
Ensembl ID		ENSG00000132963	ENSG00000092529
Uniprot IDs		Q9Y244	A0A0S2Z3E1 P20807
PDB IDs		8QYJ 8QYL 8QYM 8QYN 8QYS 8QZ9 8TM4 8TM5 8TM6 8YIX 8YIY	4OKH 6BDT 6BGP 6BJD 6BKJ
Enriched GO Terms of Interacting Partners?		Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Threonine-type Endopeptidase Activity Proteasome Complex Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Endopeptidase Activity Protein Catabolic Process Proteasomal Protein Catabolic Process Spermatoproteasome Complex Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Macromolecule Catabolic Process Proteolysis Involved In Protein Catabolic Process Peptidase Activity Proteolysis Catabolic Process Extracellular Exosome Myofibril Assembly Cytosol Cytoplasm Hydrolase Activity Actomyosin Structure Organization M Band Secretory Granule Lumen Ficolin-1-rich Granule Lumen Response To Calcium Ion Insulin-like Growth Factor Receptor Signaling Pathway Calcium-dependent Self Proteolysis Protein-containing Complex Assembly Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Guanyl-nucleotide Exchange Factor Adaptor Activity Inner Dense Plaque Of Desmosome Podosome Ring Outer Dense Plaque Of Desmosome Protein Carboxyl O-methyltransferase Activity Protein-glutamate O-methyltransferase Activity Fructose 6-phosphate Aldolase Activity Actin Cytoskeleton Organization Sarcomere Organization Structural Constituent Of Muscle Myofibril Actin Filament-based Process Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Protein-containing Complex Organization Cell-cell Junction Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle	M Band Sarcomere Organization Cytoplasm Actomyosin Structure Organization Structural Constituent Of Muscle Z Disc Endomembrane System Contractile Muscle Fiber Titin Binding Proteasome Regulatory Particle, Base Subcomplex Proteasome Complex Cytoskeletal Protein Binding Costamere Proteasome Accessory Complex Actin Cytoskeleton Organization
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